медицина (страница 33)

Автор: Claire Lewis

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell – its migration, proliferation, differentiation and structural rearrangement – is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

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Автор: Группа авторов

Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.

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Автор: Martin Herrmann

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

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Автор: Stephen Emmitt

Since the publication of the first edition of Architectural Technology, in 2002, there have been significant developments in the number of courses, the profile of the discipline as well as significant changes in the Construction sector. The Second edition of Architectural Technology addresses these challenges directly. Much greater emphasis is given to the three core themes of the book – Environmental Sustainability; Innovation; and Design. An increase in the visual material included reinforces the critical role of Design, aiding students to better translate conceptual designs into built artefacts. Building upon solid teaching practice from the previous edition, Architectural Technology is now more concisely structured to take the reader through the whole life cycle of a building, emphasising sustainability and building performance. Material on digital information, building information modelling (BIM) and information communication technologies has been updated. Most chapters have been re-titled to emphasise the importance of design and make the book more accessible to a wider range of students. Chapters conclude with updated/more extensive links to further reading. Architectural Technology, 2nd Edition: Bridges the knowledge gap between design and construction Tackles the core subjects of management, technologies and design from a sustainable building angle Addresses the buildability and performance of a design from a whole life perspective Thoroughly revised and updated this undergraduate level textbook is essential for Architectural Technology courses. Students studying Architectural Engineering, Architecture, Building Surveying; and more general Construction courses, will find the material invaluable.

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Автор: Vicente Arroyo

There has been very little written on the interaction of the liver and kidney. This book addresses the increasing incidence and significance of diseases, such as ascites, renal dysfunction, cirrhosis and hypertension where both organs are involved. This textbook is essential, even for confirmed practitioners and contains current information regarding treatment and therapy for patients with cirrhosis and ascites, clearly and effectively presented by the top international experts within this field. The second edition is entirely revised and updated and places greater emphasis on therapy.

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Автор: British Association Medical

This guide on assessment of people with some sort of mental impairment is a broad ranging report produced jointly by the British Medical Association and the Law Society. It is an authoritative statement on an important area. Its wide ranging coverage makes it essential reading for these groups. The second edition has been revised throughout to bring it right up to date with present requirements.

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Автор: Wolfram Sterry

Dieser Atlas verbindet als erster die beiden wichtigen Themengebiete der P?diatrie und Dermatologie. Da sich das Erscheinungsbild von Hauterkrankungen in der Kindheit stark von dem im Erwachsenenalter unterscheiden kann, stellt dieses einzigartige Nachschlagewerk eine wichtige Quelle sowohl f?r Dermatologen als auch P?diater dar. Der Schwerpunkt der Diagnostik von Hauterkrankungen beim Kind liegt insbesondere auf der morphologischen Befunderhebung und ihrer lokalisations- und altersabh?ngigen Manifestation. Ist die exakte klinische Beurteilung und differenzialdiagnostische Abgrenzung erfolgt, kann sie dem Kind h?ufig invasive Eingriffe zur Diagnosefindung ersparen. Hier setzt der vorliegende Atlas an. Jahrzehntelange klinische Erfahrung der drei Autoren findet in diesem Atlas ihren Ausdruck. Er lebt von seinen Abbildungen, die ihn zu einem einzigartigen Nachschlagewerk machen, das schnell den diagnostischen Blick trainiert und schult. Exzellent und umfangreich bebildert mit genauen Befundbeschreibungen und ausf?hrlichen Differenzialdiagnosen versehen, f?hrt der Atlas schnell von den Hauptmerkmalen, ?ber diagnostische Kriterien, sicher und einfach zur Diagnose und sollte somit in keiner Praxis fehlen.

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Автор: Peter Horby

The Atlas of Human Infectious Diseases provides a much needed practical and visual overview of the current distribution and determinants of major infectious diseases of humans. The comprehensive full-color maps show at a glance the areas with reported infections and outbreaks, and are accompanied by a concise summary of key information on the infectious agent and its clinical and epidemiological characteristics. Since infectious diseases are dynamic, the maps are presented in the context of a changing world, and how these changes are influencing the geographical distribution on human infections. This unique atlas: Contains more than 145 high quality full-color maps covering all major human infectious diseases Provides key information on the illustrated infectious diseases Has been compiled and reviewed by an editorial board of infectious disease experts from around the world The result is a concise atlas with a consistent format throughout, where material essential for understanding the global spatial distribution of infectious diseases has been thoughtfully assembled by international experts. Atlas of Human Infectious Diseases is an essential tool for infectious disease specialists, medical microbiologists, virologists, travel medicine specialists, and public health professionals. The Atlas of Human Infectious Diseases is accompanied by a FREE enhanced Wiley Desktop Edition – an interactive digital version of the book with downloadable images and text, highlighting and note-taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary terms.

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Автор: Panagiotis Tsapogas

The revised and updated third edition of the essential guide to the diagnosis and treatment of the diabetic foot The revised third edition of the Atlas of the Diabetic Foot is an updated guide to the information needed for the prevention and treatment of diabetic foot problems with the aim of reducing amputations. In addition to offering the theoretical knowledge, the book is filled with more than 500 color photos from real-life cases. The cases explore a wide-variety of foot issues and the text includes information about differential diagnosis and treatment. The authors—noted experts in the field—describe the epidemiology, pathophysiology and classification of diabetic foot ulcers. In addition, the book highlights the diagnosis of the main risk factors for the diabetic foot, namely diabetic neuropathy, peripheral arterial disease and the anatomic deformities of the lower extremities. The updated third edition, include 5 videos that clearly demonstrate the methods of examination for diabetic neuropathy and peripheral arterial disease. The text incldues methods of callus removal and debridement as well as offloading. In addition, it contains information on how a total contact cast is constructed. This essential resource: Contains a full colour presentation of diabetic foot cases Explains the prevention and treatment of diabetic foot problems in a revised and updated edition Includes a larger format that allows for a better quality images Offers a companion website with high-resolution digital files of photographs of the case studies presented Presents a multidisciplinary approach appropriate for a wide audience foot and diabetic professionals Written for diabetes specialists, endocrinologists and diabetic nurse specialists, podiatrists and podiatry nurse specialists, Atlas of the Diabetic Foot offers the information needed to help with the prevention, diagnosis and management of the diabetic foot.

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Автор: Nicholas Katsilambros

Many foot problems in diabetes can be prevented and often the patients are misdiagnosed, or inappropriately referred or treated. This title will be of immense use to the audience as work of reference. Diabetes mellitus is the lack of insulin leading to uncontrolled carbohydrate metabolism, the breakdown of starches and sugars into smaller units that can be used by the body for energy. Foot ulcers occur in about 15% of diabetic patients in their lifetime and hospital admissions due to foot ulcers are very common. Foot problems mostly occur when there is nerve damage in the feet or when there is poor blood flow. * Contains colour photos and pictures * Examples for identification of the patients at risk for foot ulceration * Prompt diagnosis and treatment.

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Автор: Michael Chancellor

By pairing the highest quality images with succinct text, this fully revised atlas explains methods of diagnosis, evaluation and treatment Detailing how to set up a urodynamic laboratory and discusses equipment and individual urodynamic techniques Illustrating neurologic conditions, looking at the special problems of pediatric and geriatric patients With unique, carefully reproduced urodynamic tracings and scans show you what to expect in the lab The highly regarded author team is led by Dr. Jerry Blaivas, a recognized expert in the field who received the Lifetime Achievement Award from the Society for Urodynamics and Female Urology.

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Автор: Andrea Natale

In recent years, catheter ablation of atrial fibrillation has become a widespread treatment modality in electrophysiology laboratories all over the world. Nevertheless, many aspects of the therapy are controversial. Developed by world-renowned experts in the field, this book presents a comprehensive and up-to date overview of all the most important and debated aspects of atrial fibrillation ablation, including: • Ablation techniques and technologies • Procedural endpoints • Patient management pre-, peri- and post-ablation • Anticoagulation issues • Prevention and treatment of complications • Definition of success and long-term results The text expands upon the content of the VeniceChart international consensus document on atrial fibrillation ablation and is enriched by several explanatory figures and tables. It provides a highly valuable source of information not only for researchers and specialists in electrophysiology, but also for general cardiologists, internists, fellows in cardiology and medical students.

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Автор: Raviele Antonio

This concise text presents best practices for all aspects of atrial fibrillation ablation as outlined in the new version of the VeniceChart International Consensus document, which is presented in conjunction with the biannual Venice Arrhythmias conference. In addition to discussing the latest in a-fib ablation research, this 2011 update covers all the key areas of therapy and patient management, including: • Techniques and technologies • Procedural endpoints • Patient management pre-, peri- and post-ablation • Prevention and treatment of complications • Definition of success and long-term results With contributions from the world’s recognized thought leaders in this field, this book is a highly valuable source of information not only for specialists in electrophysiology, but also for general cardiologists, fellows in cardiology and others interested in this dynamic and increasingly important topic.

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Автор: Battelino Tadej

The traditional agents for controlling the levels of glucose in the blood remain important therapies but they have their downside from the point of view of tolerability and side effects. Moreover, they appear not to be able to counter the natural history deterioration of the disease in terms of the onset of diabetic-related complications. Recent years have seen an influx of new treatment therapies and technologies aimed at achieving better glycaemic control for diabetic patients such as liraglutide (Novo Nordisk) and saxagliptin (BMS/Astra-Zeneca) and insulin pumps, away from the more traditional therapies used (classic insulin therapy, oral hypoglycaemics). This book outlines these new technologies/treatments by collating the best journal articles published in the last year, and providing expert analysis on each one. Advanced Technologies and Treatment for Diabetes 3E brings together and critically analyses the last year’s most important articles published in the world’s leading medical journals on this topic. Chapters are focused on the most current hot topic areas such as: new methods of insulin delivery; internet and IT use in treatment of diabetes; bariatric surgery & diabetes; and immunotherapy for type 1 diabetes. Each chapter includes abstracts of the published articles, scientific conclusions made, as well as annotations and a comments and analysis section from the relevant chapter editor, each of which being a well-known expert in the field. All researchers in the fields of diabetes, endocrinology and metabolism will find this book extremely useful, as will diabetes technology developers, and specialist endocrinologists involved with the care of diabetic patients.

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Автор: David Evered

This work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface-derived ``self'' antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and treatment; possible links between autoimmunity and genetic complement deficiency; the contributions of interferons and class II HLA antigen expression to autoimmunity; and the potential of monoclonal antibodies and other biotechnological advances in treating human autoimmune conditions.

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Автор: Robert Baran

This new edition brings together five leading authorities in nail surgery in this well established and definitive textbook. The entire text is extended in this edition, and particular emphasis is placed on the advances in treatments that have taken place in recent years. Considerable strides have been made in the treatment of fungal diseases (onychomycoses) with the appearance of new therapeutic agents. There is also much greater coverage of nail surgery to reflect the increasing involvement of the dermatologist in this field. The section on nail tumours has also been expanded. Drs Baran and Dawber have been joined by David de Berker, Eckhart Haneke and Antonella Tosti on the editorial team. This move is representative of the major European contribution to the field of nail surgery in recent years. Significant contribution has come from Dr Elvin Zook, the eminent American hand surgeon, who has helped to ensure that the book is as relevant in North America as it is in Europe.

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Автор: Группа авторов

The Basic Guide to Dental Procedures provides an indispensable induction to the core preventative and restorative treatments routinely carried out in the modern dental practice. Written as an introductory guide for the whole dental team, it makes no attempt to explain the theory and clinical technique behind each procedure in detail. Rather, with the aid of ‘before and after’ colour illustration it offers sufficient overview to enable the reader to understand and explain procedures to their patient with confidence. Each section is clearly structured to cover the reasoning behind the treatment described, the relevant dental background, the basics of how each procedure is carried out and if applicable, aftercare information.

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Автор: Carmen Scheller-Sheridan

Basic Guide to Dental Instruments provides a working inventory of dental instrumentation in common use in dental surgeries. A clear photograph of each instrument is included, and described according to name, usage, any relevant features and varieties. Each section is dedicated to a specific discipline or division of dentistry. Complete set-ups have been included at the end of most sections for various procedures. The coverage reflects instrumentation and accessory items used in general dental practice, routine hospital dental procedures and selected specialist settings. The author adopts a flexible approach which recognises that some instruments are multi-functional, and their names and usage can vary across dental surgeries. This approach, coupled with the range of instruments covered, makes the book an ideal 'portable' resource across general practice, hospital and a range of specialist settings. The book also highlights instruments which can be easily confused. In addition to detailing the classic sets of dental instruments, the importance of instrument care and sterilisation regimes is acknowledged. This second edition contains an expanded chapter on instruments used in conjunction with dental implants, and illustrations have been updated throughout. FEATURES Best-selling title Brand new chapter on instruments used in dental implantology Expanded chapter on dental burs Illustrations revised throughout

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Автор: Carmen Scheller-Sheridan

The Basic Guide to Dental Materials is the essential guide to dental materials for all members of the dental team. The book includes coverage of all basic dental materials, their uses and examples of each; step-by-step illustrated guidance as to the proper manipulation of materials, instructions on the four-handed delivery of dental materials and relevant instruments, practical advice on the appropriate and safe clean up and disposal of dental materials (to include how to read an MSDS sheet) and a comprehensive glossary of key terms. Information is provided in a clear and concise manner, breaking the topic of dental materials down to the core basics.

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Автор: Nicola Rogers

Sedation is a procedure that makes use of sedative medications to produce a relaxed experience for the patient. The central nervous system (CNS) is affected through the use of drugs, including tranquilizers and anxiolytics, that can be administered to the patient in several ways. Sedation dentistry has several benefits, both for dentists and patients. For patients, it can mean freedom from anxiety or fear during dental procedures. In cases where a patient has not been able to undergo dental treatment for many years because of this fear, sedation dentistry allows him to have several years' worth of dental treatment in just a few sessions. For dentists, sedation dentistry facilitates the easy performance of dental procedures. Patients are likely to be more cooperative under the relaxing effects of sedation. Treatments can also be quicker, because a number of procedures can be performed in a single session. Dental nurses play a vital role in assisting the dentist in the routine sedation of patients. In acknowledgement of this, the NEBDN run a post-qualification certificate in Dental Sedation Nursing that provides the dental nurse with the theoretical knowledge and practical skills required to carry out their role safely and competently. The ‘Basic Guide to Dental Sedation Nursing' is a must have book for all dental nurses seeking to develop their knowledge and understanding of this core area of clinical practice. Written in a clear and accessible style, chapters reflect the Certificate in Dental Sedation Nursing syllabus with chapters on such key topics as legal aspects, anatomy, equipment, patient assessment, types of sedation, medical emergencies and resuscitation. Illustrated in full colour throughout Handy format for easy reference and portability Evidence-based

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Автор: Pankhurst Caroline L

The Basic Guide to Infection Prevention and Control in Dentistry is a practical guide for all members of the dental team. It offers clear explanations of the key issues and concepts, an orientation of the evidence base and legal framework as well as providing a step-by-step guide to the safe running of a dental practice. Chapters cover key topics, namely: communicable diseases; occupational health and immunisation; decontamination of dental equipment; surgery disinfect ion; sharp safe working; hand hygiene and barrier personal protection; dental unit waterlines, clinical waste management and pathology specimen handling.

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Автор: Felton Simon

Step by step course companion for dental nurses studying for the Certificate in Oral Health Education. Topics covered include dental structures, anatomy and physiology, oral diseases and prevention, the principles of education, oral health and society, promoting oral health in the 21st century, patient communication, project planning and workplace assignments. This second edition has been thoroughly updated in line with the substantial changes to the role of the dental nurse since the 1st edition was published. To address this, a brand new section has been added on education and research.

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Автор: Fiona Grist

The Basic Guide to Orthodontic Dental Nursing is a must-have introduction for those seeking to develop their knowledge and understanding of this core area of clinical practice. Written in a clear and accessible format, with colour illustration throughout, the book is a guide for all dental nurses with an interest in orthodontics. It is designed to reflect sections of the syllabus of the Certificate in Orthodontic Dental Nursing. Chapters cover such key topics as tooth eruption patterns, removable and fixed appliances, de-bonding, and retention. There are also sections on care prior to treatment, including the requirements for a first appointment, and there is helpful guidance on maintaining motivation – particularly for young patients and their parents. Published in a compact format for portability and easy reference, this is a valuable addition to the Basic Guides series.

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Автор: Группа авторов

How to conduct clinical trials in an ethical and scientifically responsible manner This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case–involving a treatment for hypertension after open heart surgery–and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives. The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Not only do they contribute essays on the scientific, technological, legal, and ethical aspects of clinical trials, but they also critique and debate each other's opinions, creating an interesting, personalized text. Bayesian Methods and Ethics in a Clinical Trial Design * Answers commonly raised questions about Bayesian methods * Describes the advantages and disadvantages of this method compared with other methods * Applies current ethical theory to a particular class of design for clinical trials * Discusses issues of informed consent and how to serve a patient's best interest while still obtaining uncontaminated scientific data * Shows how to use Bayesian probabilistic methods to create computer models from elicited prior opinions of medical experts on the best treatment for a type of patient * Contains several chapters on the process, results, and computational aspects of the test case in question * Explores American law and the legal ramifications of using human subjects For statisticians and biostatisticians, and for anyone involved with medicine and public health, this book provides both a practical guide and a unique perspective on the connection between technological developments, human factors, and some of the larger ethical issues of our times.

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Автор: Группа авторов

This important and extremely interesting book is a serious scientific and authoritative overview of the implications of drinking beer as part of the human diet. Coverage includes a history of beer in the diet, an overview of beer production and beer compositional analysis, the impact of raw materials, the desirable and undesirable components in beer and the contribution of beer to health, and social issues. Written by Professor Charlie Bamforth, well known for a lifetime's work in the brewing world, Beer: Health and Nutrition should find a place on the shelves of all those involved in providing dietary advice.

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Автор: Alain Goeppert

Completely revised and updated, the third edition of this bestseller discusses the concept and ongoing development of using methanol as a transportation fuel, energy storage medium, and as a raw material to replace oil. The contents have been expanded by 35% with new chapters on energy storage, methanol from biomass and waste products, as well as on carbon dioxide recycling. Written by the late Nobel laureate George Olah and his team, this is an inspiring read for anyone concerned with the major challenge posed by tomorrow's energy and environmental problems.

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Автор: Waksman Dr. Ron

Here is expert guidance on one of the most vexing clinical challenges faced by interventional cardiologists. Written by global thought leaders in the area and edited by two internationally-recognized pioneers in interventional cardiology, Bifurcation Stenting covers all techniques, imaging modalities, and devices in current use, including VH-IVUS and OCT. It includes practical tips/tricks from leading experts and a section of challenging cases to further illustrate the material and help readers better understand the treatment of bifurcation lesions.

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Автор: CIBA Foundation Symposium

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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Автор: Dieter Hauschke

Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.

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Автор: Glenn McGee

How far is too far? 60 cases illustrating modern bioethical dilemmas Bioethics for Beginners maps the giant dilemmas posed by new technologies and medical choices, using 60 cases taken from our headlines, and from the worlds of medicine and science. This eminently readable book takes it one case at a time, shedding light on the social, economic and legal side of 21st century medicine while giving the reader an informed basis on which to answer personal, practical questions. Unlocking the debate behind the headlines, this book combines clear thinking with the very latest in science and medicine, enabling readers to decide for themselves exactly what the scientific future should hold.

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Автор: Paul Barry

Bioinformatics, Biocomputing and Perl presents a modern introduction to bioinformatics computing skills and practice. Structuring its presentation around four main areas of study, this book covers the skills vital to the day-to-day activities of today’s bioinformatician. Each chapter contains a series of maxims designed to highlight key points and there are exercises to supplement and cement the introduced material. Working with Perl presents an extended tutorial introduction to programming through Perl, the premier programming technology of the bioinformatics community. Even though no previous programming experience is assumed, completing the tutorial equips the reader with the ability to produce powerful custom programs with ease. Working with Data applies the programming skills acquired to processing a variety of bioinformatics data. In addition to advice on working with important data stores such as the Protein DataBank, SWISS-PROT, EMBL and the GenBank, considerable discussion is devoted to using bioinformatics data to populate relational database systems. The popular MySQL database is used in all examples. Working with the Web presents a discussion of the Web-based technologies that allow the bioinformatics researcher to publish both data and applications on the Internet. Working with Applications shifts gear from creating custom programs to using them. The tools described include Clustal-W, EMBOSS, STRIDE, BLAST and Xmgrace. An introduction to the important Bioperl Project concludes this chapter and rounds off the book.

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Автор: Группа авторов

“… this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once…” Human Vaccines, 2010 «… This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies… This book may well serve as a first line of reference for all biologists and computer scientists…» –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

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Автор: Gregory Bock R

An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.

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Автор: James de Lemos

Biomarkers in Heart Disease is the first title in the AHA Clinical Series and is aimed at meeting the needs of clinicians, providing cardiologists, internists, emergency physicians, laboratorians, and other healthcare providers with a clear understanding of the role of biomarkers in contemporary cardiovascular medicine. The book covers both the strengths and pitfalls of currently available markers, and provides information on the most promising biomarkers that are likely to impact practice in the next few years. It is divided into four parts, organized around clinical scenarios rather than individual biomarkers. This book will help the practicing physician decide which biomarkers to measure, when to measure them, how to interpret the results and how to make decisions based on the test result.

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Автор: Vladimir Zatsiorsky

Biomechanics in Sport is a unique reference text prepared by the leading world experts in sport biomechanics. Over thirty chapters cover a broad spectrum of topics, ranging from muscle mechanics to injury prevention, and from aerial movement to wheelchair sport. The biomechanics of sports including running, skating, skiing, swimming, jumping in athletics, figure skating, ski jumping, diving, javelin and hammer throwing, shot putting, and striking movements are all explained.

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Автор: Carpi Federico

Giving fundamental information on one of the most promising families of smart materials, electroactive polymers (EAP) this exciting new titles focuses on the several biomedical applications made possible by these types of materials and their related actuation technologies. Each chapter provides a description of the specific EAP material and device configuration used, material processing, device assembling and testing, along with a description of the biomedical application. Edited by well-respected academics in the field of electroactive polymers with contributions from renowned international experts, this is an excellent resource for industrial and academic research scientists, engineers, technicians and graduate students working with polymer actuators or in the fields of polymer science.

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Автор: Murray Logan

R – the statistical and graphical environment is rapidly emerging as an important set of teaching and research tools for biologists. This book draws upon the popularity and free availability of R to couple the theory and practice of biostatistics into a single treatment, so as to provide a textbook for biologists learning statistics, R, or both. An abridged description of biostatistical principles and analysis sequence keys are combined together with worked examples of the practical use of R into a complete practical guide to designing and analyzing real biological research. Topics covered include: simple hypothesis testing, graphing exploratory data analysis and graphical summaries regression (linear, multi and non-linear) simple and complex ANOVA and ANCOVA designs (including nested, factorial, blocking, spit-plot and repeated measures) frequency analysis and generalized linear models. Linear mixed effects modeling is also incorporated extensively throughout as an alternative to traditional modeling techniques. The book is accompanied by a companion website www.wiley.com/go/logan/r with an extensive set of resources comprising all R scripts and data sets used in the book, additional worked examples, the biology package, and other instructional materials and links.

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Автор: Thomas Lumley

A respected introduction to biostatistics, thoroughly updated and revised The first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today’s aspiring and practicing medical scientist. This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and levels of proficiency. Written with an eye toward the use of computer applications, the book examines the design of medical studies, descriptive statistics, and introductory ideas of probability theory and statistical inference; explores more advanced statistical methods; and illustrates important current uses of biostatistics. New to this edition are discussions of Longitudinal data analysis Randomized clinical trials Bayesian statistics GEE The bootstrap method Enhanced by a companion Web site providing data sets, selected problems and solutions, and examples from such current topics as HIV/AIDS, this is a thoroughly current, comprehensive introduction to the field.

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Автор: A. Oliveira Gouveia

Study design and statistical methodology are two important concerns for the clinical researcher. This book sets out to address both issues in a clear and concise manner. The presentation of statistical theory starts from basic concepts, such as the properties of means and variances, the properties of the Normal distribution and the Central Limit Theorem and leads to more advanced topics such as maximum likelihood estimation, inverse variance and stepwise regression as well as, time-to-event, and event-count methods. Furthermore, this book explores sampling methods, study design and statistical methods and is organized according to the areas of application of each of the statistical methods and the corresponding study designs. Illustrations, working examples, computer simulations and geometrical approaches, rather than mathematical expressions and formulae, are used throughout the book to explain every statistical method. Biostatisticians and researchers in the medical and pharmaceutical industry who need guidance on the design and analyis of medical research will find this book useful as well as graduate students of statistics and mathematics with an interest in biostatistics. Biostatistics Decoded: Provides clear explanations of key statistical concepts with a firm emphasis on practical aspects of design and analysis of medical research. Features worked examples to illustrate each statistical method using computer simulations and geometrical approaches, rather than mathematical expressions and formulae. Explores the main types of clinical research studies, such as, descriptive, analytical and experimental studies. Addresses advanced modeling techniques such as interaction analysis and encoding by reference and polynomial regression.

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Автор: John Pezzullo

Score your highest in biostatistics Biostatistics is a required course for students of medicine, epidemiology, forestry, agriculture, bioinformatics, and public health. In years past this course has been mainly a graduate-level requirement; however its application is growing and course offerings at the undergraduate level are exploding. Biostatistics For Dummies is an excellent resource for those taking a course, as well as for those in need of a handy reference to this complex material. Biostatisticians—analysts of biological data—are charged with finding answers to some of the world's most pressing health questions: how safe or effective are drugs hitting the market today? What causes autism? What are the risk factors for cardiovascular disease? Are those risk factors different for men and women or different ethnic groups? Biostatistics For Dummies examines these and other questions associated with the study of biostatistics. Provides plain-English explanations of techniques and clinical examples to help Serves as an excellent course supplement for those struggling with the complexities of the biostatistics Tracks to a typical, introductory biostatistics course Biostatistics For Dummies is an excellent resource for anyone looking to succeed in this difficult course.

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Автор: Dawn Freshwater

This dictionary is clear, concise and easy to use…My advice to anyone wishing to purchase a nursing dictionary would be to…buy this one Journal of Advanced Nursing (on the first edition) All the information you’ll ever need – in one dictionary! Key features * Over 15,000 entries * Comprehensive – much more information than a pocket dictionary * Informed by current nursing research and clinical practice * Includes latest UK legislation and policy changes * Accessible, authoritative and contemporary * Invaluable and informative appendices Appendices include: · Normal values · Lists of websites for key nursing journals and organizations · The NMC code of professional conduct · QAA benchmarking standards · Nursing research, Information technology and emergency care · Continuing professional development and PREP requirements “very user friendly” European Journal of Cancer Care (on the first edition)

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Автор: CIBA Foundation Symposium

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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Автор: Группа авторов

This book explores the potential of bone grafting techniques to rehabilitate the maxilla through the placement of dental implants. As implant dentistry becomes increasingly well established and sophisticated, this book will help experienced surgeons to involve implant solutions as part of more challenging reconstructions in the upper jaw. Starting with a recap on principles of bone biology, the book then considers implant integration in normal bone and with bone grafts. Grafting procedures are presented depicting a variety of bone harvest sites, followed by onlay and inlay grafting techniques. Approaches to sinus lifting, segmental osteotomy and distraction osteogenesis for augmentation protocols are provided.

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Автор: Barbara Bain J

Written by one of the world's leading haematologists, and three renowned histopathologists, Bone Marrow Pathology provides a comprehensive guide to the diagnosis of bone marrow disease. Now in its Third Edition, the text has been extensively revised and rewritten to reflect the latest advances in the field. Features: An extremely practical, up-to-the-minute text incorporating the new WHO classification of haematopoietic malignancies A comprehensive text written with great precision and clarity of style Incorporates a new section 'Problems and Pitfalls' – a unique section that will aid the working pathologist faced with a difficult situation An important text for the haematologist, histopathologist and haematopathologist with equal weight given to peripheral blood, aspirate, trephine biology and specialized techniques Extensively illustrated with many of the photographs being of paraffin-embedded sections Combines all the techniques now applied to bone marrow diagnosis, including immunocytochemistry, flow cytometery, immunohistochemistry and the diagnostic role of cytogenetic and molecular genetic analysis

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Автор: Douglas Rothman L

This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders. Novel and potentially controversial Will inspire future research directions

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Автор: CIBA Foundation Symposium

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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Автор: Cox Neil

Evidence-based, peer reviewed, best-practice management guidelines for dermatologists Incorporates the basic guidelines that have been expanded with extra material including: Web address for the guideline Editorial comment Links to additional guidelines from other international organizations Links to the BAD’s patient-information leaflets Other patient-oriented information. The guidelines themselves are grouped for ease of use into: Dermatoses Infections Neoplasms Specific therapeutic agents The guidelines provide a thoroughly rounded and grounded approach to best-practice dermatologic management using evidence-based principles with additional access to patient-oriented information. For fast access to proven standards of care, dermatologists worldwide can turn to the BAD Management Guidelines with confidence.

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Автор: Peter Clayton

This new edition of the benchmark text on clinical pediatric endocrinology still remains at the forefront of world clinical opinion. Furthermore, the style, which has been the hallmark of the book for the last 20 years, has been maintained for this Fifth Edition. New features of this Fifth Edition include: Special new chapters cover the fetal origins of adult disease and the endocrine consequences and management of critical illness Now opens with a basic science section summarizing the mechanisms of hormone action, genomics, proteomics and the application of molecular biology to clinical practice Two new co-editors have been introduced – Peter Clayton and Rosalind Brown Every chapter has been updated

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Автор: Claire Boyd

Providing nursing students with words of wisdom and advice from real-life student nurses, Calculation Skills for Nurses enables you to calculate drug dosages with ease, boosting your confidence and competence in this core area of nursing practice. The book takes away the fear of calculations, making it approachable, easy and fun, and ties in with the NMC standards for pre-registration education and the Essential Skills Clusters. It is filled with examples and questions based on real life nursing and healthcare situations and includes key information displayed on the inside back cover for quick look-up on clinical placements.

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Автор: Rosalind Eeles A

Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

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Автор: Rimas Orentas

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.

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