органическая химия

Автор: А. В. Салин

В монографии рассмотрены возможности использования третичных фосфинов в качестве катализаторов в реакции Михаэля. Материал структурирован в соответствии с природой используемого в реакции непредельного электрофильного соединения и нуклеофила. Монография предназначена для химиков, занимающихся органокатализом, асимметрическим катализом, синтезом биологически активных соединений, а также для студентов и аспирантов, специализирующихся в области химии элементоорганических соединений и катализа.

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Автор: А. И. Артеменко

В книге особое внимание уделено основным классам органических соединений. На современном уровне изложены вопросы взаимного влияния атомов в молекуле, изомерии, теории гибридизации орбиталей, механизмов некоторых реакций и т.п., содержатся все сведения о ВМС, ПАВ, красителях и т. д. Соответствует современным требованиям Федерального государственного образовательного стандарта среднего профессионального образования и профессиональным квалификационным требованиям. Предназначен для студентов средних профессиональных учебных заведений.

Серия: Среднее профессиональное образование (Лань)

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Автор: Аркадий Аверченко

«Всеобщая история» вышла в таком составе: 1. Древняя история – Н.А. Тэффи. 2. Средняя история – Осипа Дымова. 3. Новая история – Аркадия Аверченко. 4. Русская история – О.Л. Д’Ора. «… Хотя наша „Всеобщая история“ и не будет рекомендована ученым Комитетом, состоящим при м-ве народного просвещения, – как руководство для учебных заведений, но эта книга даст подписчикам единственный случай взглянуть на историческое прошлое народов – в совершенно новом и вполне оригинальном освещении… »

Исполнители: Светлана Шандр

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Автор: Группа авторов

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

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Автор: Группа авторов

Provides comprehensive coverage on recidivism risk/needs assessment tools Correctional and healthcare professionals around the world utilize structured instruments referred to as risk/needs assessment tools to predict the likelihood that an offender will recidivate. Such tools have been found to provide accurate and reliable evaluations and are widely used to assess, manage, and monitor offenders both institutionally as well as in the community. By identifying offenders in need of different levels of intervention, examining causal risk factors, and individualizing case management plans, risk/needs assessment tools have proven invaluable in addressing the public health issue of recidivism. Recidivism Risk/Needs Assessment Tools brings together the developers of the most commonly-used risk/needs assessment tools to provide a comprehensive overview of their development, peer-reviewed research literature, and practical application. Written by the leading professionals in the field of risk/needs assessment, the book provides chapters on: Recidivism Risk Assessment in the 21st Century; Performance of Recidivism Risk Assessment Instruments in Correctional Settings; Correctional Offender Management Profiles for Alternative Sanctions (COMPAS); the Federal Post-Conviction Risk Assessment Instrument; the Inventory of Offender Risks, Needs, and Strengths (IORNS); the Level of Service (LS) Instruments; the Ohio Risk Assessment System (ORAS); the Self-Appraisal Questionnaire (SAQ); the Service Planning Instrument (SPIn); the Static Risk Offender Needs Guide-Revised (STRONG-R); the Offender Group Reconviction Scale (OGRS); the Forensic Operationalized Therapy/Risk Evaluation System (FOTRES); the RisCanvi; and more. Systematically identifies currently-validated recidivism risk/needs assessment tools Reviews research on recidivism risk/needs assessment tools used internationally Each chapter presents sufficient detail to decide whether a given recidivism risk/needs assessment tool is right for your practice Recidivism Risk/Needs Assessment Tools is ideal for correctional, probation and parole, and behavioral health professionals.

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Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to «real» screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real «how to» book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.

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Автор: Группа авторов

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Библиографический указатель посвящен Мукаттису Бариевичу Газизову – доктору химических наук, академику Российской академии естествознания, члену Национального географического общества США, члену Нью-Йоркской академии наук, Заслуженному деятелю науки Республики Татарстан, Заслуженному работнику высшей школы РФ, Заслуженному деятелю науки и образования РАЕ.

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Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: • Satellite aerosol remote sensing • The effects of aerosols on climate change • Air pollution and health • Pharmaceutical aerosols and pulmonary drug delivery • Bioaerosols and hospital infections • Particle emissions from vehicles • The safety of emerging nanomaterials • Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public’s attention after the eruption of the Icelandic volcano Eyjafjallaj?kull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.

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Offers a comprehensive guide to the isolation, properties and applications of chitin and chitosan Chitin and Chitosan: Properties and Applications presents a comprehensive review of the isolation, properties and applications of chitin and chitosan. These promising biomaterials have the potential to be broadly applied and there is a growing market for these biopolymers in areas such as medical and pharmaceutical, packaging, agricultural, textile, cosmetics, nanoparticles and more. The authors – noted experts in the field – explore the isolation, characterization and the physical and chemical properties of chitin and chitosan. They also examine their properties such as hydrogels, immunomodulation and biotechnology, antimicrobial activity and chemical enzymatic modifications. The book offers an analysis of the myriad medical and pharmaceutical applications as well as a review of applications in other areas. In addition, the authors discuss regulations, markets and perspectives for the use of chitin and chitosan. This important book: Offers a thorough review of the isolation, properties and applications of chitin and chitosan. Contains information on the wide-ranging applications and growing market demand for chitin and chitosan Includes a discussion of current regulations and the outlook for the future Written for Researchers in academia and industry who are working in the fields of chitin and chitosan, Chitin and Chitosan: Properties and Applications offers a review of these promising biomaterials that have great potential due to their material properties and biological functionalities.

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A comprehensive introduction to coastal storms and their associated impacts Coastal Storms offers students and professionals in the field a comprehensive overview and groundbreaking text that is specifically devoted to the analysis of coastal storms. Based on the most recent knowledge and contributions from leading researchers, the text examines coastal storms’ processes and characteristics, the main hazards (such as overwash, inundation and flooding, erosion, structures overtopping), and how to monitor and model storms. The authors include information on the most advanced innovations in forecasting, prediction, and early warning, which serves as a foundation for accurate risk evaluation and developing adequate coastal indicators and management options. In addition, structural overtopping and damage are explained, taking into account the involved hydrodynamic and morphodynamic processes. The monitoring methods of coastal storms are analyzed based on recent results from research projects in Europe and the United States. Methods for vulnerability and risk evaluation are detailed, storm impact indicators are suggested for different hazards and coastal management procedures analyzed. This important resource includes: Comprehensive coverage of storms and associated impacts, including meteorological coastal storm definitions and related potential consequences A state-of-the-art reference for advanced students, professionals and researchers in the field Chapters on monitoring methods of coastal storms, their prediction, early warning systems, and modeling of consequences Explorations of methods for vulnerability and risk evaluation and suggestions for storm impact indicators for different hazards and coastal management procedures Coastal Storms is a compilation of scientific and policy-related knowledge related to climate-related extreme events. The authors are internationally recognized experts and their work reflects the most recent science and policy advances in the field.

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Cellulosic Energy Cropping Systems presents a comprehensive overview of how cellulosic energy crops can be sustainably produced and converted to affordable energy through liquid fuels, heat and electricity. The book begins with an introduction to cellulosic feedstocks, discussing their potential as a large-scale sustainable energy source, and technologies for the production of liquid fuels, heat and electricity. Subsequent chapters examine miscanthus, switchgrass, sugarcane and energy cane, sorghums and crop residues, reviewing their phylogeny, cultural practices, and opportunities for genetic improvement. This is followed by a detailed focus on woody crops, including eucalyptus, pine, poplar and willow. Critical logistical issues associated with both herbaceous and woody feedstocks are reviewed, and alternate strategies for harvesting, transporting, and storing cellulosic materials are also examined. The final sectionof the booktackles the challenge of achieving long-term sustainability, addressing economic, environmental and social factors. Cellulosic Energy Cropping Systems is a valuable resource for academics, students and industry professionals working in the field of biomass cultivation and conversion, bioenergy, crop science and agriculture. Topics covered include: Identifying suitable cellulosic energy crops that are adapted to a wide range of climates and soils Best management practices for sustainably growing, harvesting, storing, transporting and pre-processing these crops The development of integrated cellulosic energy cropping systems for supplying commercial processing plants Challenges and opportunities for the long-term sustainability of cellulosic energy crops This book was conceived and initiated by David I. Bransby, Professor of Energy and Forage Crops in the Department of Crop, Soil and Environmental Sciences at Auburn University, USA. For more information on the Wiley Series in Renewable Resources, visit www.wiley.com/go/rrs

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Closing a gap in the literature, this comprehensive book presents the utility of carbohydrate derivatives as chiral auxiliaries, reagents, complex ligands and organocatalysts, together with details of their preparation, as well as their successful application in stereoselective synthesis. Divided into four parts: * Carbohydrate Auxiliaries * Carbohydrate Reagents * Carbohydrate Ligands * Carbohydrate Organocatalysts It is an indispensable source for every organic chemist.

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Exhibiting both homogeneous and heterogeneous catalytic properties, nanocatalysts allow for rapid and selective chemical transformations, with the benefits of excellent product yield and ease of catalyst separation and recovery. This book reviews the catalytic performance and the synthesis and characterization of nanocatalysts, examining the current state of the art and pointing the way towards new avenues of research. Moreover, the authors discuss new and emerging applications of nanocatalysts and nanocatalysis, from pharmaceuticals to fine chemicals to renewable energy to biotransformations. Nanocatalysis features contributions from leading research groups around the world. These contributions reflect a thorough review of the current literature as well as the authors’ first-hand experience designing and synthesizing nanocatalysts and developing new applications for them. The book’s nineteen chapters offer a broad perspective, covering: Nanocatalysis for carbon-carbon and carbon-heteroatom coupling reactions Nanocatalysis for various organic transformations in fine chemical synthesis Nanocatalysis for oxidation, hydrogenation, and other related reactions Nanomaterial-based photocatalysis and biocatalysis Nanocatalysts to produce non-conventional energy such as hydrogen and biofuels Nanocatalysts and nano-biocatalysts in the chemical industry Readers will also learn about the latest spectroscopic and microscopy tools used in advanced characterization methods that shed new light on nanocatalysts and nanocatalysis. Moreover, the authors offer expert advice to help readers develop strategies to improve catalytic performance. Summarizing and reviewing all the most important advances in nanocatalysis over the last two decades, this book explains the many advantages of nanocatalysts over conventional homogeneous and heterogeneous catalysts, providing the information and guidance needed for designing green, sustainable catalytic processes.

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Organic Reaction Mechanisms 2013, the 49th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2013. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

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A unique and timely review of the emergence of eukaryotic virulence in fungi, oomycetes, and protozoa, as they affect both animals and plants Evolution of Virulence in Eukaryotic Microbes addresses new developments in defining the molecular basis of virulence in eukaryotic pathogens. By examining how pathogenic determinants have evolved in concert with their hosts, often overcoming innate and adaptive immune mechanisms, the book takes a fresh look at the selective processes that have shaped their evolution. Introductory chapters ground the reader in principal evolutionary themes such as phylogenetics and genetic exchange, building a basis of knowledge for later chapters covering advances in genetic tools, how pathogens exchange genetic material in nature, and the common themes of evolutionary adaptation that lead to disease in different hosts. With the goal of linking the research findings of the many disparate scientific communities in the field, the book: Assembles for the first time a collection of chapters on the diversity of eukaryotic microorganisms and the influence of evolutionary forces on the origins and emergence of their virulent attributes Highlights examples from three important, divergent groups of eukaryotic microorganisms that cause disease in animals and plants: oomycetes, protozoan parasites, and fungi Covers how the development of genetic tools has fostered the identification and functional analyses of virulence determinants Addresses how pathogens exchange genetic material in nature via classical or modified meiotic processes, horizontal gene transfer, and sexual cycles including those that are cryptic or even unisexual Provides a broad framework for formulating future studies by illustrating themes common to different pathogenic microbes Evolution of Virulence in Eukaryotic Microbes is an ideal book for microbiologists, evolutionary biologists and medical professionals, as well as graduate students, postdoctoral fellows, and faculty members working on the evolution of pathogens.

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Animal Cruelty Investigations: A Collaborative Approach from Victim to Verdict provides a framework for the experts who respond to animal cruelty cases: veterinarians, law enforcement agencies, animal care and control organizations, and prosecutors. This book is a practical guide which provides insight and direction for every phase of an animal cruelty investigation. The step-by-step guidance on responding to particular issues and challenges related to animal cruelty cases is bolstered by the extensive library of checklists, form templates, specific case protocols, and lists of available resources. This book is designed to empower readers to respond to animal cruelty cases confidently and effectively by: Introducing veterinarians to their critical role in animal cruelty investigations including forensic examination and necropsy, crime scene response, report writing, and testimony. Included are detailed Specific Case Protocols for common animal cruelty scenarios. Helping animal shelters navigate the challenges of holding animals in protective custody, housing unusual species, and placing evidence animals in foster care. Offering law enforcement agencies useful methods for investigating animal cruelty such as search and seizure protocols, witness interview techniques, and valuable forms and templates necessary to strengthen and ensure proper search warrant execution, evidence collection and handling, and chain of custody; all with a focus on animals as both victims and evidence. Guiding prosecutors through the steps necessary to utilize the veterinarian’s findings during trial and providing insight into issues to be considered when reviewing search warrants, filing charges, proposing plea agreements, or filing pre-conviction forfeiture motions. This book is a must-have reference and guide for veterinarians, technicians, law enforcement officers, prosecutors, and all those involved in the protection of animals’ health and wellbeing. The successful investigation of animal crimes relies on each of these disciplines, not only carrying out their professional duties, but having a collective understanding of what each other needs in order to meet that expectation.

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From droplet formation to final applications, this practical book presents the subject in a comprehensive and clear form, using only content derived from the latest published results. Starting at the very beginning, the topic of fluid mechanics is explained, allowing for a suitable regime for printing inks to subsequently be selected. There then follows a discussion on different print-head types and how to form droplets, covering the behavior of droplets in flight and upon impact with the substrate, as well as the droplet's wetting and drying behavior at the substrate. Commonly observed effects, such as the coffee ring effect, are included as well as printing in the third dimension. The book concludes with a look at what the future holds. As a unique feature, worked examples both at the practical and simulation level, as well as case studies are included. As a result, students and engineers in R&D will come to fully understand the complete process of inkjet printing.

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Medicinal plants contain a variety of bioactive compounds, (also referred to as phytochemicals). in the leaves, stems, flowers and fruits. This book covers these bioactive compounds, their available sources, how the bioactive molecules are isolated from the plants, the biochemistry, structural composition and potential biological activities. Also discussed are the pharmacological aspects of medicinal plants, phytochemistry and biological activities of different natural products, ethnobotany and medicinal properties, as well as a novel dietary approach for various disease management and therapeutic potential. The importance of phytopharmaceutical of plants and potential applications in the food and pharma industries is highlighted.

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Fuels, Chemicals and Materials from the Oceans and Aquatic Sources provides a holistic view of fuels, chemicals and materials from renewable sources in the oceans and other aquatic media. It presents established and recent results regarding the use of water-based biomass, both plants and animals,for value-added applications beyond food. The book begins with an introductory chapter which provides an overview of ocean and aquatic sources for the production of chemicals and materials. Subsequent chapters focus on the use of various ocean bioresources and feedstocks, including microalgae, macroalgae, and waste from aquaculture and fishing industries, including fish oils, crustacean and mollusc shells. Fuels, Chemicals and Materials from the Oceans and Aquatic Sources serves as a valuable reference for academic and industrial professionals working on the production of chemicals, materials and fuels from renewable feedstocks. It will also prove useful for researchers in the fields of green and sustainable chemistry, marine sciences and biotechnology. Topics covered include: • Production and conversion of green macroalgae • Marine macroalgal biomass as an energy feedstock • Microalgae bioproduction • Bioproduction and utilization of chitin and chitosan • Applications of mollusc shells • Crude fish oil as a potential fuel

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This book reflects the increasing interest among the chemical synthetic community in the area of asymmetric copper-catalyzed reactions, and introduces readers to the latest, most significant developments in the field. The contents are organized according to reaction type and cover mechanistic and spectroscopic aspects as well as applications in the synthesis of natural products. A whole chapter is devoted to understanding how primary organometallics interact with copper to provide selective catalysts for allylic substitution and conjugate addition, both of which are treated in separate chapters. Another is devoted to the variety of substrates and experimental protocols, while an entire chapter covers the use on non-carbon nucleophiles. Other chapters deal with less-known reactions, such as carbometallation or the additions to imines and related systems, while the more established reactions cyclopropanation and aziridination as well as the use of copper (II) Lewis acids are warranted their own special chapters. Two further chapters concern the processes involved, as determined by mechanistic studies. Finally, a whole chapter is devoted to the synthetic applications. This is essential reading for researchers at academic institutions and professionals at pharmaceutical or agrochemical companies.

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The Companion to Ancient Israel offers an innovative overview of ancient Israelite culture and history, richly informed by a variety of approaches and fields. Distinguished scholars provide original contributions that explore the tradition in all its complexity, multiplicity and diversity. A methodologically sophisticated overview of ancient Israelite culture that provides insights into political and social history, culture, and methodology Explores what we can say about the cultures and history of the people of Israel and Judah, but also investigates how we know what we know Presents fresh insights, richly informed by a variety of approaches and fields Delves into ‘religion as lived,’ an approach that asks about the everyday lives of ordinary people and the material cultures that they construct and experience Each essay is an original contribution to the subject

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Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world

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In contrast to the classical books which largely focus on separate, individual physicochemical and biological aspects, this book aims to integrate the frontiers of knowledge on the fundamentals and the impact of physicochemical and biological interactions and processes of AOCs in soil, sediment, water and air. The specific objectives of this book are to address: (1) fundamental biophysico-chemical processes of AOCs in the environment, (2) occurrence and distribution of AOCs in air, water, and soil, and their global cycling, (3) the state-of-the-art analytical techniques of AOCs, and (4) restoration of natural environments contaminated by AOCs. The book also identifies the gaps in knowledge on the subject matter and as such provides future directions to stimulate scientific research to advance the chemical science on biophysico-chemical interfacial reactions in natural habitats. By virtue of complex nature of the interactions of AOCs with different environmental components and matrixes, no single available technique and instrument is satisfactory yet for determining their fate, transport, availability, and risk in the environment. In order to fully understand the biophysico-chemical interactions and processes of AOCs in the environment, it is critical to know chemical, physical and biological properties of AOCs and their analytical techniques. The book is unique because of its multidisciplinary approach as it provides a comprehensive and integrated coverage of biophysico-chemical reactions and processes of AOCs in various environments, associated analytical techniques, and restoration of natural environments contaminated by AOCs.

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This unique book gives a timely overview about the fundamentals and applications of supported ionic liquids in modern organic synthesis. It introduces the concept and synthesis of SILP materials and presents important applications in the field of catalysis (e.g. hydroformylation, hydrogenation, coupling reactions, fine chemical synthesis) as well as energy technology and gas separation. Written by pioneers in the field, this book is an invaluable reference book for organic chemists in academia or industry.

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Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.

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This book aims to overview the role of non-covalent interactions, such as hydrogen and halogen bonding, π-π, π-anion and electrostatic interactions, hydrophobic effects and van der Waals forces in the synthesis of organic and inorganic compounds, as well as in design of new crystals and function materials. The proposed book should allow to combine, in a systematic way, recent advances on the application of non-covalent interactions in synthesis and design of new compounds and functional materials with significance in Inorganic, Organic, Coordination, Organometallic, Pharmaceutical, Biological and Material Chemistries. Therefore, it should present a multi- and interdisciplinary character assuring a rather broad scope. We believe it will be of interest to a wide range of academic and research staff concerning the synthesis of new compounds, catalysis and materials. Each chapter will be written by authors who are well known experts in their respective fields.

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The conceptualization and formulation of skin care products intended for topical use is a multifaceted and evolving area of science. Formulators must account for myriad skin types, emerging opportunities for product development as well as a very temperamental retail market. Originally published as “Apply Topically” in 2013 (now out of print), this reissued detailed and comprehensive handbook offers a practical approach to the formulation chemist’s day-to-day endeavors by: • Addressing the innumerable challenges facing the chemist both in design and at the bench, such as formulating with/for specific properties; formulation, processing and production techniques; sensory and elegancy; stability and preservation; color cosmetics; sunscreens; • Offering valuable guidance to troubleshooting issues regarding ingredient selection and interaction, regulatory concerns that must be addressed early in development, and the extrapolation of preservative systems, fragrances, stability and texture aids; • Exploring the advantages and limitations of raw materials; • Addressing scale-up and pilot production process and concerns; • Testing and Measurements Methods. The 22 chapters written by industry experts such as Roger L. McMullen, Paul Thau, Hemi Nae, Ada Polla, Howard Epstein, Joseph Albanese, Mark Chandler, Steve Herman, Gary Kelm, Patricia Aikens, and Sam Shefer, along with many others, give the reader and user the ultimate handbook on topical product development.

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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

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This book highlights the display applications of c-axis aligned crystalline indium–gallium–zinc oxide (CAAC-IGZO), a new class of oxide material that challenges the dominance of silicon in the field of thin film semiconductor devices. It is an enabler for displays with high resolution and low power consumption, as well as high-productivity manufacturing. The applications of CAAC-IGZO focus on liquid crystal displays (LCDs) with extremely low power consumption for mobile applications, and high-resolution and flexible organic light-emitting diode (OLED) displays, and present a large number of prototypes developed at the Semiconductor Energy Laboratory. In particular, the description of LCDs includes how CAAC-IGZO enables LCDs with extremely low refresh rate that provides ultra-low power consumption in a wide range of use cases. Moreover, this book also offers the latest data of IGZO. The IGZO has recently achieved a mobility of 65.5 cm2?}V-s, and it is expected to potentially exceed 100 cm2?}V-s as high as that of LTPS. A further two books in the series will describe the fundamentals of CAAC-IGZO, and the application to LSI devices. Key features: • Introduces different oxide semiconductor field-effect transistor designs and their impact on the reliability and performance of LCDs and OLED displays, both in pixel and panel-integrated driving circuits. • Reviews fundamentals and presents device architectures for high-performance and flexible OLED displays, their circuit designs, and oxide semiconductors as an enabling technology. • Explains how oxide semiconductor thin-film transistors drastically can improve resolution and lower power consumption of LCDs.

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An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term «bioorganometallics», and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.

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A singular collection of original essays exploring the varied intersections of motion pictures and public value A Companion to Motion Pictures and Public Value presents a cross-disciplinary investigation of the past, present, and possible future contributions of the moving image to the public good. This unique volume explores the direct and indirect public value developed through motion pictures of different types, genres, and screening sites. Essays by world-renowned scholars from diverse disciplines present original conceptual work, philosophical arguments, historical discussion, empirical research, and specific case studies. Divided into seven thematically organized sections, the Companion identifies the various kinds of values that motion pictures can deliver, amongst them artistic, ethical, environmental, cultural, political, cognitive, and spiritual value. Each section includes an introduction in which the editors outline main themes and highlight connections between individual chapters. Throughout the text, probing essays interrogate the issue of public value as it relates to the cinema and provide insight into how motion pictures play a positive role in human life and society. Featuring original research essays on a pioneering topic, this innovative reference text: Brings together work by expert authors in disciplines such as Philosophy, Political Science, Cultural Studies, Film Studies, Sociology, and Environmental Studies Discusses a variety of institutional landscapes, policy formations, and types and styles of filmmaking Provides wide and inclusive coverage of cinema’s relation to public value in Africa, Asia, China, Europe, the Middle East, and the Americas Explores the role of motion pictures in community formation, nation building, and the construction of good societies Covers new and emerging topics such as cinema-based fields focused on health and wellbeing A Companion to Motion Pictures and Public Value is an ideal textbook for advanced undergraduate and graduate courses in Film, Media, and Cultural Studies, and is a valuable resource for scholars across a variety of disciplines

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The third edition of the bestselling two-volume reference covers everything you need to know about microwave technology for synthesis – from the best equipment to nonthermal effects, from solid-support reactions to catalysis. Completely revised and updated with half of the authors completely new to the project, this comprehensive work is clearly divided into two parts on the fundamentals of microwave irradiation, and application of microwaves and synergies with other enabling techniques. Also new to this edition are chapters on on-line monitoring, flow chemistry, combination with ultrasounds and natural products, including multicomponent reactions. An indispensable source for organic, catalytic, physical, and medicinal chemists.

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Anesthesia and the Fetus integrates into one volume the multidisciplinary components of: fetal development fetal pharmacology assessments of fetal and neonatal outcome anesthesia and analgesia during pregnancy anesthesia and analgesia during labor ethics and law Written by an internationally renowned group of clinicians and scientists, Anesthesia and the Fetus provides a contemporary guide and reference to the role of anesthesia, and the anesthesiologist, in protecting the mother and her unborn child during pregnancy.

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The book containing 18 chapters is divided into three parts: Part 1: Fundamentals of Ice Formation and Ice Characteristics; Part 2: Ice Adhesion and Its Measurement; and Part 3: Methods to Mitigate Ice Adhesion. The topics covered Include: Factors influencing the formation, adhesion and friction of ice; ice nucleation on solid surfaces; physics of ice nucleation and growth on a surface; condensation frosting; defrosting properties of structured surfaces; relationship between surface free energy and ice adhesion to surfaces; metrology of ice adhesion; test methods for quantifying ice adhesion strength to surfaces; interlaboratory studies of ice adhesion strength; mechanisms of surface icing and deicing technologies; anti-icing using microstructured surfaces; durability assessment of icephobic coatings; bio-inspired icephobic coatings; challenges in rational fabrication of icephobic surfaces; protection from ice accretion on aircraft; and numerical modeling and its application to inflight icing.

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