фармакология (страница 8)

Автор: Группа авторов

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

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Автор: Группа авторов

How can the needs and perspective of patients be incorporated in the design and redesign of health services? Health organizations are focusing more and more on patients – and requiring their employees to practise patient focused care. The Modernisation Initiative described in this book explores in three health service areas (kidney, stroke and sexual health services) how patients' and carers' involvement may inform and shape quality improvement work This book guides you through the issues and challenges that teams seeking to involve users in changing health services are likely to face. It offers a wealth of practical knowledge about involving users. Those undertaking similar programmes, whether in primary care or hospital based, will find ideas and examples in this book to inspire and guide them.

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Автор: Gomtsyan Arthur

Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it «the holy grail» of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.

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Автор: Hackett Timothy B

Veterinary Emergency and Critical Care Procedures, Second Edition is a step-by-step guide to key emergency and critical care procedures encountered in both general and specialty practice. Now in full color, the second edition includes several new procedures, two new chapters covering cardiopulmonary resuscitation and continuous rate infusions, and a companion website offering videos demonstrating most of the procedures featured in the book. Helpful hints have also been added throughout to make the book even more useful in the practice setting. Each procedure includes information on the background, supplies needed, indications, and contraindications, followed by a series of images demonstrating the technique. This practical resource, ideally designed for use in fast-paced emergency situations, is an indispensable reference for any member of the veterinary team.

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Автор: Группа авторов

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to «real» screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real «how to» book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.

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Автор: Rebecca Dmytryk

Rescuing wild animals in distress requires a unique set of skills, very different from those used in handling domestic animals. The equipment, degree of handling, the type of caging and level of care a wild animal receives can mean the difference between life and death. Wildlife Search and Rescue is a comprehensive guide on ‘best practices’ and suggested standards for response to sick, injured and orphaned wildlife. This valuable resource covers the fundamentals of wildlife rescue, from ‘phone to field’, including safe and successful capture strategies, handling and restraint techniques and initial aid. Wildlife Search and Rescue is a must have for anyone interested in knowing what to do when they are face to face with a wild animal in need, or for anyone involved in animal rescue. While the book focuses on wildlife native to North America, much of the information and many of the techniques are applicable to other species, including domestic dogs and cats. Visit www.wiley.com/go/dmytryk/wildlifeemergency to access the figures from the book.

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Автор: Victor M. Lyatkher

An up-to-date and thorough treatment of the technologies, practical applications, and future of wind power, with the pros and cons and technical intricacies of various types of wind turbines and wind power prediction With the demand for energy outstripping availability from conventional sources such as fossil fuels, new sources of energy must be found. Wind power is the most mature of all of the renewable or alternative sources of energy being widely used today. With many old wind turbines becoming obsolete or in need of replacement, new methods and materials for building turbines are constantly being sought after, and troubleshooting, from an engineering perspective, is paramount to the operational efficiency of turbines currently in use. Wind Power: Turbine Design, Selection, and Optimization: Details the technical attributes of various types of wind turbines, including new collinear windmills, orthogonal windmills, non-vibration VAWT wind turbines, and others Covers all the updated protocols for wind power and its applications Offers a thorough explanation of the current and future state of wind power Is suitable not only as a reference for the engineer working with wind power but as a textbook for graduate students, postdoctoral students, and researchers Wind power is one of the fastest-growing, oldest, and «greenest» of the major sources of renewable energy that has been developed, with more efficient and cost-effective technologies and materials now constantly being sought for turbines and the equipment used with them. Here is a comprehensive and thorough review of the engineering pros and cons of using different kinds of wind turbines in different environments, including offshore. With full technical knowledge, engineers, managers, and other decision-makers in the wind energy industry can make more informed decisions about increasing capacity, cost-efficiency, and equipment longevity. Covering the various types of wind turbines available, such as new collinear windmills, orthogonal turbines, and others, this highly technical treatment of wind turbines offers engineers, students, and researchers insight into the practical applications of these turbines and their potential for maximum efficiency.

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Автор: Rosemary Ommer

This exciting new book grew out of an international symposium held at FAO, Rome in July 2008, but it is not just a collection of papers from that symposium. Rather, the publication brings together work on social-ecological marine research that cuts across disciplines, identifies key common elements and approaches that promote resilience of marine social-ecological systems in the face of global changes, and points to next steps. The book comprises contributions on conceptual issues relating to social-ecological responses in marine systems to global changes; offers illustrative case studies of specific examples of social-ecological responses in marine systems to significant environmental changes manifested locally; develops a syntheses between natural and social scientists on the topic, and points the way forward with innovative approaches to the use of science and knowledge in management, policy and advice. World Fisheries is part of Wiley-Blackwell's prestigious Fish and Aquatic Resources Series, and encompasses chapters from many scientists at the top of their fields worldwide. Carefully drawn together and edited by four world experts in the area, World Fisheries is a landmark publication which is an essential purchase for all fisheries managers worldwide.

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