общая биология (страница 15)

Автор: Lorenzo Cerroni

Skin lymphomas are relatively rare but potentially fatal They can easily be misdiagnosed as benign skin diseases. Dermatologists and pathologists need to have a good understanding of the clinical presentations and the pathological correlates of this challenging disease to ensure the correct diagnosis and most appropriate treatment is provided. Skin Lymphoma: The Illustrated Guide is a full-color illustrated text and atlas that combines pathology with clinical features and treatment. Jam-packed with pictures that illustrate key diagnostic points and supplemented by teaching cases to highlight effective decision making. It includes all newly identified entities and provides pointers on how to differentiate these. In addition, it also covers all inflammatory conditions that may simulate skin lymphomas (cutaneous pseudolymphomas). Skin Lymphoma: The Illustrated Guide provides Clinical and pathological guidance on diagnosis of skin lymphomas Clear illustrations to aid visual recognition Nomenclature according to WHO/EORTC classifications Cases to enhance the scope for teaching and learning This fully refreshed fourth edition continues to provide the clinical excellence that has helped a generation of dermatologists and dermatopathologists to effectively diagnose skin lymphoma.

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Автор: Barry C. McCarthy

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Автор: Группа авторов

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Автор: Rajiv K. Varma

Learn the fundamentals of smart photovoltaic (PV) inverter technology with this insightful one-stop resource Smart Solar PV Inverters with Advanced Grid Support Functionalities presents a comprehensive coverage of smart PV inverter technologies in alleviating grid integration challenges of solar PV systems and for additionally enhancing grid reliability. Accomplished author Rajiv Varma systematically integrates information from the wealth of knowledge on smart inverters available from EPRI, NREL, NERC, SIWG, EU-PVSEC, CIGRE, IEEE publications; and utility experiences worldwide. The book further presents a novel, author-developed and patented smart inverter technology for utilizing solar PV plants both in the night and day as a Flexible AC Transmission System (FACTS) Controller STATCOM, named PV-STATCOM. Replete with case studies, this book includes over 600 references and 280 illustrations. Smart Solar PV Inverters with Advanced Grid Support Functionalities’ features include: Concepts of active and reactive power control; description of different smart inverter functions, and modeling of smart PV inverter systems Distribution system applications of PV-STATCOM for dynamic voltage control, enhancing connectivity of solar PV and wind farms, and stabilization of critical motors Transmission system applications of PV-STATCOM for improving power transfer capacity, power oscillation damping (POD), suppression of subsynchronous oscillations, mitigation of fault induced delayed voltage recovery (FIDVR), and fast frequency response (FFR) with POD Hosting capacity for solar PV systems, its enhancement through effective settings of different smart inverter functions; and control coordination of smart PV inverters Emerging smart inverter grid support functions and their pioneering field demonstrations worldwide, including Canada, USA, UK, Chile, and India. Perfect for system planners and system operators, utility engineers, inverter manufacturers and solar farm developers, this book will prove to be an important resource for academics and graduate students involved in electrical power and renewable energy systems.

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Автор: Группа авторов

This book will discuss the effective and sustainable technological approaches for remediation of contaminates via eco-friendly usage of microbes. The primary focus will be on the role of microbes, particularly bacteria and fungi, for the degradation and removal of various xenobiotic substances in the environment.
The book will also emphasize molecular approaches and biosynthetic pathways of microbes, and present gene and protein expression studies for bio-deterioration techniques. New innovative and sophisticated green technologies for waste minimization and waste control will be presented, as well as the potential of microbes for various techniques of bioremediation, including bio-sorption, bio-augmentation, bio-stimulation, to clean contaminated environments.

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Автор: Группа авторов

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Автор: Jean-Luc Lefebvre

Strategy is the art of thinking about war before it occurs. Noting that space already plays a role in all of today’s wars, Space Strategy studies how conflicts are extending into this new domain. The book defines extra-atmospheric space and focuses on its varying features and constraints. By exploring the opportunities for action provided by different strategic positions, the book analyzes the most plausible combat scenarios from, against and within space. It explains the concepts of militarization, weaponization and martialization of space and shows how space systems constitute an essential component of information literacy – the key to power in the 21st Century. Space Strategy then demonstrates why our society, having become space-dependent, must take appropriate measures to develop its spatioresilience. Finally, the author summarizes his reflections in the form of a mnemonic listing twelve principles of space strategy. Completed by educational appendices and a glossary containing one thousand entries, Space Strategy meets the needs of students, researchers or any other reader curious about expanding their knowledge of strategy.

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Автор: Klaus D. Kluckert

Der Autor zeigt anhand eigener Erlebnisse aus seinem Berufsleben als Ingenieur im operativen Geschaft und als Sachverstandiger typische Fehler im Spezialtiefbau auf, analysiert deren Ursachen und zeigt Wege zur Beseitigung auf. Mit diesem «etwas anderen Lehrbuch» fasst er sein gespeichertes Wissen zusammen und lasst dabei Kollegen, Berufsanfanger und Studenten an seinem wertvollen Erfahrungsschatz teilhaben. Das Buch soll helfen, den einen oder anderen Fehler mit seinen mitunter gravierenden personlichen und finanziellen Konsequenzen zu vermeiden und dadurch auch die Unfallgefahren zu minimieren.

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Автор: Lady (Mary Anne) Barker

Station Amusements in New Zealand by Lady (Mary Anne) Barker libreka classics – These are classics of literary history, reissued and made available to a wide audience. Immerse yourself in well-known and popular titles!

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Автор: Lady (Mary Anne) Barker

Station Life in New Zealand by Lady (Mary Anne) Barker libreka classics – These are classics of literary history, reissued and made available to a wide audience. Immerse yourself in well-known and popular titles!

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Автор: John Davis H

An insightful, hands-on focus on the statistical methods used by compensation and human resources professionals in their everyday work Across various industries, compensation professionals work to organize and analyze aspects of employment that deal with elements of pay, such as deciding base salary, bonus, and commission provided by an employer to its employees for work performed. Acknowledging the numerous quantitative analyses of data that are a part of this everyday work, Statistics for Compensation provides a comprehensive guide to the key statistical tools and techniques needed to perform those analyses and to help organizations make fully informed compensation decisions. This self-contained book is the first of its kind to explore the use of various quantitative methods—from basic notions about percents to multiple linear regression—that are used in the management, design, and implementation of powerful compensation strategies. Drawing upon his extensive experience as a consultant, practitioner, and teacher of both statistics and compensation, the author focuses on the usefulness of the techniques and their immediate application to everyday compensation work, thoroughly explaining major areas such as: Frequency distributions and histograms Measures of location and variability Model building Linear models Exponential curve models Maturity curve models Power models Market models and salary survey analysis Linear and exponential integrated market models Job pricing market models Throughout the book, rigorous definitions and step-by-step procedures clearly explain and demonstrate how to apply the presented statistical techniques. Each chapter concludes with a set of exercises, and various case studies showcase the topic's real-world relevance. The book also features an extensive glossary of key statistical terms and an appendix with technical details. Data for the examples and practice problems are available in the book and on a related FTP site. Statistics for Compensation is an excellent reference for compensation professionals, human resources professionals, and other practitioners responsible for any aspect of base pay, incentive pay, sales compensation, and executive compensation in their organizations. It can also serve as a supplement for compensation courses at the upper-undergraduate and graduate levels.

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Автор: Peter Goos

Statistics with JMP: Hypothesis Tests, ANOVA and Regression Peter Goos, University of Leuven and University of Antwerp, Belgium David Meintrup, University of Applied Sciences Ingolstadt, Germany A first course on basic statistical methodology using JMP This book provides a first course on parameter estimation (point estimates and confidence interval estimates), hypothesis testing, ANOVA and simple linear regression. The authors approach combines mathematical depth with numerous examples and demonstrations using the JMP software. Key features: Provides a comprehensive and rigorous presentation of introductory statistics that has been extensively classroom tested. Pays attention to the usual parametric hypothesis tests as well as to non-parametric tests (including the calculation of exact p-values). Discusses the power of various statistical tests, along with examples in JMP to enable in-sight into this difficult topic. Promotes the use of graphs and confidence intervals in addition to p-values. Course materials and tutorials for teaching are available on the book's companion website. Masters and advanced students in applied statistics, industrial engineering, business engineering, civil engineering and bio-science engineering will find this book beneficial. It also provides a useful resource for teachers of statistics particularly in the area of engineering.

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Автор: Группа авторов

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

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Автор: Steve Goodhew

This book explores the concepts and practicalities that lead to sustainable construction. It breaks new ground by providing the reader with the underlying principles of how to build sustainably and then assesses many of the tools required for the task. From energy to materials and from procurement to operation, all aspects play their part in turning a theoretically sustainable building project into a reality. There are many guidelines for the designer on how to maximise the sustainability of buildings but this resource text supplements these by focusing on the construction and operational aspects of sustainable buildings, as well as some of the more fundamental design-related considerations. ? Offers an excellent text for those learning to construct, design and operate sustainable buildings. ? Covers the drivers for sustainable construction, definitions, historical impacts, climate change and global, regional and individual responses. ? enables the construction professional to achieve optimum solutions, both in design, process and the aftercare of buildings. ? evaluates the effectiveness of different renewable technologies and provides guidance on the practicalities of their use. ? Alerts the reader to future trends in this field.

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Автор: Группа авторов

An effective and cost efficient protection of electronic system against ESD stress pulses specified by IEC 61000-4-2 is paramount for any system design. This pioneering book presents the collective knowledge of system designers and system testing experts and state-of-the-art techniques for achieving efficient system-level ESD protection, with minimum impact on the system performance. All categories of system failures ranging from 'hard' to 'soft' types are considered to review simulation and tool applications that can be used. The principal focus of System Level ESD Co-Design is defining and establishing the importance of co-design efforts from both IC supplier and system builder perspectives. ESD designers often face challenges in meeting customers' system-level ESD requirements and, therefore, a clear understanding of the techniques presented here will facilitate effective simulation approaches leading to better solutions without compromising system performance. With contributions from Robert Ashton, Jeffrey Dunnihoo, Micheal Hopkins, Pratik Maheshwari, David Pomerenke, Wolfgang Reinprecht, and Matti Usumaki, readers benefit from hands-on experience and in-depth knowledge in topics ranging from ESD design and the physics of system ESD phenomena to tools and techniques to address soft failures and strategies to design ESD-robust systems that include mobile and automotive applications. The first dedicated resource to system-level ESD co-design, this is an essential reference for industry ESD designers, system builders, IC suppliers and customers and also Original Equipment Manufacturers (OEMs). Key features: Clarifies the concept of system level ESD protection. Introduces a co-design approach for ESD robust systems. Details soft and hard ESD fail mechanisms. Detailed protection strategies for both mobile and automotive applications. Explains simulation tools and methodology for system level ESD co-design and overviews available test methods and standards. Highlights economic benefits of system ESD co-design.

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Автор: Nicolas Buclet

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Автор: Sir Arthur Conan Doyle

Исполнители: Peter Silverleaf

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Автор: Josh Altman

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Автор: Группа авторов

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

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Автор: Группа авторов

Fully revised and restructured, this fresh edition offers students and trainee social workers an incisive and authoritative introduction to the subject. As well as entirely new sections on theory and practice, the expert contributions which have shaped the companion’s leading reputation have been updated and now include innovative standalone essays on social work theory. Comprehensively reworked new edition comprising six substantive sections covering essential topics for trainee social workers – in effect, six books in one Includes an extensive introduction and chapters by leading experts on the focus and purpose of social work Provides a unified textbook for trainees and an invaluable professional reference volume Features a wealth of new material on theory and practice alongside detailed expositions of the social and psychological framework, stages in the human life cycle, and the objectives and core components of social work Each chapter lists five key points to remember, questions for discussion, and recommendations for further reading

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Автор: Kevin P. Gallagher

After the 2008–9 global financial crisis, reforms to promote stability, social inclusion, and sustainability were promised but not delivered. As a result, the global economic situation, marred by inequality, volatility, and climate breakdown, remains dysfunctional. Now, the economic fallout from the Covid-19 pandemic offers us a second chance. Kevin Gallagher and Richard Kozul-Wright argue that we must grasp it by implementing sweeping reforms to how we govern global money, finance, and trade. Without global leaders prepared to boldly rewrite the rules to promote a prosperous, just, and sustainable post-Covid world economic order – a Bretton Woods moment for the twenty-first century – we risk being engulfed by climate chaos and political dysfunction. This book provides a blueprint for change that no one interested in the future of our planet can afford to miss.

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Автор: Michel Loreau

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Автор: Cyril G. Hopkins

libreka classics – These are classics of literary history, reissued and made available to a wide audience. Immerse yourself in well-known and popular titles!

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Автор: Marcy A. Kelly

The Fundamentals of Scientific Research: An Introductory Laboratory Manual is a laboratory manual geared towards first semester undergraduates enrolled in general biology courses focusing on cell biology. This laboratory curriculum centers on studying a single organism throughout the entire semester – Serratia marcescens, or S. marcescens, a bacterium unique in its production of the red pigment prodigiosin. The manual separates the laboratory course into two separate modules. The first module familiarizes students with the organism and lab equipment by performing growth curves, Lowry protein assays, quantifying prodigiosin and ATP production, and by performing complementation studies to understand the biochemical pathway responsible for prodigiosin production. Students learn to use Microsoft Excel to prepare and present data in graphical format, and how to calculate their data into meaningful numbers that can be compared across experiments. The second module requires that the students employ UV mutagenesis to generate hyper-pigmented mutants of S. marcescens for further characterization. Students use experimental data and protocols learned in the first module to help them develop their own hypotheses, experimental protocols, and to analyze their own data. Before each lab, students are required to answer questions designed to probe their understanding of required pre-laboratory reading materials. Questions also guide the students through the development of hypotheses and predictions. Following each laboratory, students then answer a series of post-laboratory questions to guide them through the presentation and analysis of their data, and how to place their data into the context of primary literature. Students are also asked to review their initial hypotheses and predictions to determine if their conclusions are supportive. A formal laboratory report is also to be completed after each module, in a format similar to that of primary scientific literature. The Fundamentals of Scientific Research: An Introductory Laboratory Manual is an invaluable resource to undergraduates majoring in the life sciences.

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Автор: Группа авторов

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

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Автор: Gregory Bock R

A comprehensive volume examining the fundamental questions raised by reductionists' theory about levels of explanation necessary to understand biological systems. The book evaluates the enormously powerful techniques of molecular biology, and analyzes precisely how molecular information has improved our understanding of fundamental biological processes.

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Автор: Robert Handfield

Creates a managerial compass for entering into the LIVING (Live, Intelligent, Velocity, Interactive, Networked, and Good) era of supply chain management and defines the imperative for creating Velocity and Visibility as the focal point for exploiting new digital, mobile, and cloud-based technologies Written by well-known researchers in the field, this book addresses the changes that have occurred and are still unfolding at various organizations that are involved in building real-time supply chains. The authors draw on their experiences with multiple companies, along with references to the natural evolution of ecosystems throughout to help identify the “new rules of supply chain management." The LIVING principles associated with the rapid digitization and technology changes occurring in the global economy are discussed, along with the push to become more sustainable and responsive to customer needs. “ Handfield and Linton reveal the “secret ingredient” to leveraging the power of a well managed supply chain….will revolutionize the way companies approach supply chain management.” Frank Crespo, Vice President, Global Supply Network Division (CPO/Logistics/IoT Analytics), Caterpillar Inc. “ The LIVING supply chain is a wake up call to any enterprise that depends on suppliers and contractors. Be fast, be nimble and make supply chain transparency the nucleus of your operations or become endangered.” Paul Massih, Vice President, BP PSCM “ …a fascinating journey through the future of supply chain management … a must read for every supplychain professional.” Yossi Sheffi, Professor, MIT Center for Transportation and Logistics “ … a great “living” reading on how to bring supply chains to a powerful living state. The idea of Live-Interactive-Velocity–Intelligent–Networked-Good is the foundation of how supply chains can be agile, adaptive and aligned. …of value to every supply chain executive and practitioner.” Hau Lee, Professor, Stanford University “ Successful businesses are those that support the success of their customers. This book captures the essence of our volatile, uncertain world and the opportunities that exist for the commercially astute, organizationally integrated business. More important, it offers insight to the recipe for 21st century operations and the management of complex supply ecosystems.” Tim Cummins, CEO, International Association of Commercial and Contract Management “ A LIVING supply chain requires a living company. The authors make a great case for how Flex is creating a living company to thrive in the living supply chain.” Tom Choi, Harold E. Fear on Eminent Scholar Chair of Purchasing Management, Arizona State University, Executive Director, CAPS Research “ To survive we need to have an adaptive supply chain and capability to both optimize and adapt simultaneously. This book begins to describe the ability to shift from functional silos to E2E Frictionless flow with the maturity to make E2E tradeoff decisions as a key enabler for success.” Wayne Rothman, Vice President, Enterprise Supply Chain Planning, Johnson & Johnson “A fantastic read and excellent stories from Dr. Handfield and Tom.” Joanne E. Wright, Vice President, IBM Supply Chain ROBERT HANDFIELD, PhD, is Bank of America University Distinguished Professor of Supply Chain Management and Director of the Supply Chain Resource Cooperative at North Carolina State University. The author of four books and over 150 journal articles, Dr. Handfield received his PhD in Opera

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Автор: Группа авторов

Each year, some two million people in the United Kingdom experience visual hallucinations. Infrequent, fleeting visual hallucinations, often around sleep, are a usual feature of life. In contrast, consistent, frequent, persistent hallucinations during waking are strongly associated with clinical disorders; in particular delirium, eye disease, psychosis, and dementia. Research interest in these disorders has driven a rapid expansion in investigatory techniques, new evidence, and explanatory models. In parallel, a move to generative models of normal visual function has resolved the theoretical tension between veridical and hallucinatory perceptions. From initial fragmented areas of investigation, the field has become increasingly coherent over the last decade. Controversies and gaps remain, but for the first time the shapes of possible unifying models are becoming clear, along with the techniques for testing these. This book provides a comprehensive survey of the neuroscience of visual hallucinations and the clinical techniques for testing these. It brings together the very latest evidence from cognitive neuropsychology, neuroimaging, neuropathology, and neuropharmacology, placing this within current models of visual perception. Leading researchers from a range of clinical and basic science areas describe visual hallucinations in their historical and scientific context, combining introductory information with up-to-date discoveries. They discuss results from the main investigatory techniques applied in a range of clinical disorders. The final section outlines future research directions investigating the potential for new understandings of veridical and hallucinatory perceptions, and for treatments of problematic hallucinations. Fully comprehensive, this is an essential reference for clinicians in the fields of the psychology and psychiatry of hallucinations, as well as for researchers in departments, research institutes and libraries. It has strong foundations in neuroscience, cognitive science, optometry, psychiatry, psychology, clinical medicine, and philosophy. With its lucid explanation and many illustrations, it is a clear resource for educators and advanced undergraduate and graduate students.

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Автор: Marie Bergstr?m

Online dating has become a widespread feature of modern social life. In less than two decades, seeking partners through commercial intermediaries went from being a marginal and stigmatized practice to being a common activity. How can we explain this rapid change and what does it tell us about the changing nature of love and sexuality? In contrast to those who praise online dating as a democratization of love and those who condemn it as a commodification of intimacy, this book tells a different story about how and why online dating became big. The key to understanding the growing prevalence of digital dating lies in what Marie Bergstr?m calls “the privatization of intimacy.” Online dating takes courtship from the public to the private sphere and makes it a domestic and individual practice. Unlike courtship in traditional settings such as school, work, and gatherings of family and friends, online dating makes a clear distinction between social and sexual sociability and renders dating much more discrete. Apparently banal, this privatizing feature is fundamental for understanding both the success and the nature of digital matchmaking. Bergstr?m also sheds light on the persisting inequalities of intimate life, showing that online dating is neither free nor fair: it has its winners and losers and it differs significantly according to gender, age and social class. Drawing on a wide range of empirical material, this book challenges what we think we know about online dating and gives us a new understanding of who, why, and how people go online to seek sex and love.

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Автор: Pascale Cossart

Microbiology has undergone radical changes over the past few decades, ushering in an exciting new era in science. In The New Microbiology , Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology. This story has wide-ranging implications for human health and medicine, agriculture, environmental science, and our understanding of evolution. The revolution results from the powerful tools of molecular and cellular biology, genomics, and bioinformatics, which have yielded amazing discoveries, from entire genome sequences to video of bacteria invading host cells. This book is for both scientists and especially nonscientists who would like to learn more about the extraordinary world of bacteria. Dr. Cossart's overview of the field of microbiology research, from infectious disease history to the ongoing scientific revolution resulting from CRISPR technologies, is presented in four parts. New concepts in microbiology introduces the world of bacteria and some recent discoveries about how they live, such as the role of regulatory RNAs including riboswitches, the CRISPR defense system, and resistance to antibiotics. Sociomicrobiology: the social lives of bacteria helps us see the new paradigm by which scientists view bacteria as highly social creatures that communicate in many ways, for example in the assemblies that reside in our intestine or in the environment. The biology of infections reviews some of history's worst epidemics and describes current and emerging infectious diseases, the organisms that cause them, and how they produce an infection. Bacteria as tools introduces us to molecules derived from microbes that scientists have harnessed in the service of research and medicine, including the CRISPR/Cas9 genome-editing technology. The New Microbiology takes us on a journey through a remarkable revolution in science that is occurring here and now.

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Автор: James A. DiNardo

Written by an expert author team at the renowned Boston Children's Hospital, USA, The Pediatric Cardiac Anesthesia Handbook provides a comprehensive yet concise overview of the anesthetic management of pediatric patients with congenital heart disease. This book is divided into two parts. The first part provides an introduction to the basic assessment of patients, including cardiovascular physiology, pathophysiology and the underlying concepts in coronary heart disease, preoperative evaluation, intraoperative management, and interpretation of cardiac catheterization data. The second part of the book addresses disorders and diseases in a templated manner covering the anatomical and physiological features, surgical therapies, anesthetic approach and postoperative management. Chapters on the heart and heart and lung transplantation consider the additional complexities of those patients and anesthetic considerations for non-cardiac surgery after heart transplantation. The anesthesiologist caring for patients with congenital heart disease faces a myriad of challenges in the perioperative management of these complex individuals. This book provides: A concise and easily referable guide ideal for use during anesthesiology residency training and fellowships. A templated chapter layout ideal for easy referral by wider members of the multidisciplinary team, such as cardiologists, cardiac intensivists, perfusionists, and surgeons. Helpful illustrations and a bulleted content for rapid reference. Guidelines on specific lesions for the pediatric anesthesiologist caring for cardiac patients presenting for non-cardiac surgery. This book is a valuable resource for all anesthesiology and cardiac critical care providers who manage patients with congenital heart disease, and an ideal study aid.

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Автор: Irwin W. Sherman

The Power of Plagues presents a rogues' gallery of epidemic- causing microorganisms placed in the context of world history. Author Irwin W. Sherman introduces the microbes that caused these epidemics and the people who sought (and still seek) to understand how diseases and epidemics are managed. What makes this book especially fascinating are the many threads that Sherman weaves together as he explains how plagues past and present have shaped the outcome of wars and altered the course of medicine, religion, education, feudalism, and science. Cholera gave birth to the field of epidemiology. The bubonic plague epidemic that began in 1346 led to the formation of universities in cities far from the major centers of learning (and hot spots of the Black Death) at that time. And the Anopheles mosquito and malaria aided General George Washington during the American Revolution. Sadly, when microbes have inflicted death and suffering, people have sometimes responded by invoking discrimination, scapegoating, and quarantine, often unfairly, against races or classes of people presumed to be the cause of the epidemic. Pathogens are not the only stars of this book. Many scientists and physicians who toiled to understand, treat, and prevent these plagues are also featured. Sherman tells engaging tales of the development of vaccines, anesthesia, antiseptics, and antibiotics. This arsenal has dramatically reduced the suffering and death caused by infectious diseases, but these plague protectors are imperfect, due to their side effects or attenuation and because microbes almost invariably develop resistance to antimicrobial drugs. The Power of Plagues provides a sobering reminder that plagues are not a thing of the past. Along with the persistence of tuberculosis, malaria, river blindness, and AIDS, emerging and remerging epidemics continue to confound global and national public health efforts. West Nile virus, Lyme disease, and Ebola and Zika viruses are just some of the newest rogues to plague humans. The argument that civilization has been shaped to a significant degree by the power of plagues is compelling, and The Power of Plagues makes the case in an engaging and informative way that will be satisfying to scientists and non-scientists alike.

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Автор: Группа авторов

Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 190. The Stratosphere: Dynamics, Transport, and Chemistry is the first volume in 20 years that offers a comprehensive review of the Earth's stratosphere, increasingly recognized as an important component of the climate system. The volume addresses key advances in our understanding of the stratospheric circulation and transport and summarizes the last two decades of research to provide a concise yet comprehensive overview of the state of the field. This monograph reviews many important aspects of the dynamics, transport, and chemistry of the stratosphere by some of the world's leading experts, including up-to-date discussions of Dynamics of stratospheric polar vortices Chemistry and dynamics of the ozone hole Role of solar variability in the stratosphere Effect of gravity waves in the stratosphere Importance of atmospheric annular modes This volume will be of interest to graduate students and scientists who wish to learn more about the stratosphere. It will also be useful to atmospheric science departments as a textbook for classes on the stratosphere.

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Автор: Maurice Hulle

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Автор: Maurice Hulle

The sub-Antarctic islands are remote and isolated environments with original flora and fauna composed of a few species that are highly adapted to cold oceanic conditions. Their peculiar naturalness makes these ecosystems intrinsically fragile.

This book focuses on terrestrial ecosystems and, in particular, on invertebrates – earthworms, mollusks, spiders and insects – that inhabit the French sub-Antarctic islands of the South Indian Ocean. All native and introduced species are presented in the form of individual fact sheets, which include the main identification criteria, geographical distribution and principal ecological traits. Numerous summary tables, distribution maps of introduced species, and a discussion on the originality and vulnerability of this fauna are also included.

The Terrestrial Macroinvertebrates of the Sub-Antarctic Iles Kerguelen and Ile de la Possession is based on an expansive literature base, as well as on observations and photographs taken as part of a research program funded by the French Polar Institute Paul-Emile Victor (IPEV). The book also gives an important part to the history of the discoveries of the different species, as well as current conservation issues.

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Автор: Oleg Konovalov

Noted CEOs, academics, and military personnel share their experience as visionary leaders The Vision Code explores the concept of «vision» and leadership. The book reveals the secrets of building and executing a strong vision within any organization. Oleg Konovalov—an acclaimed global thought leader—draws together in one volume in-depth interviews with nineteen extraordinary global visionaries that represent a variety of industries and organizations. These leaders explain why a vision is needed, how to implement it, how to communicate a vision effectively, and how to live by it with integrity. As Konovalov explains, vision is a key leadership skill that can be developed as a practical business tool for leading a company today and into the future. The stories of the nineteen leaders reveal how to develop a compelling vision and follow through with the vision in order to inspire an entire workforce. When a leader taps into the power of «vision,» he or she creates a more meaningful business experience and ultimately, a better life. This compelling book: Offers a guide for making the concept of vision a reality Provides the information needed to develop a clear and persuasive vision Contains an accessible guide to a much-needed skill Includes interviews with Marshall Goldsmith (#1 Leadership Thinker), Martin Lindstrom (#1 Branding Expert), Garry Ridge (Chairman and CEO of WD-40 Company) and many others Written for leaders at all levels in organizations and industries of any type The Vision Code is a must-have book for anyone who wants to develop the skill to become a visionary leader.

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Автор: Группа авторов

The Wiley Handbook on the Cognitive Neuroscience of Learning charts the evolution of associative analysis and the neuroscientific study of behavior as parallel approaches to understanding how the brain learns that both challenge and inform each other. Covers a broad range of topics while maintaining an overarching integrative approach Includes contributions from leading authorities in the fields of cognitive neuroscience, associative learning, and behavioral psychology Extends beyond the psychological study of learning to incorporate coverage of the latest developments in neuroscientific research

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Автор: Группа авторов

The Wiley Handbook of Theoretical and Philosophical Psychology presents a comprehensive exploration of the wide range of methodological approaches utilized in the contemporary field of theoretical and philosophical psychology. The Wiley Handbook of Theoretical and Philosophical Psychology presents a comprehensive exploration of the wide range of methodological approaches utilized in the contemporary field of theoretical and philosophical psychology. Gathers together for the first time all the approaches and methods that define scholarly practice in theoretical and philosophical psychology Chapters explore various philosophical and conceptual approaches, historical approaches, narrative approaches to the nature of human conduct, mixed-method studies of psychology and psychological inquiry, and various theoretical bases of contemporary psychotherapeutic practices Features contributions from ten Past Presidents of the Society of Theoretical and Philosophical Psychology, along with several Past Presidents of other relevant societies

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Автор: David Peterson

A state-of-the-art reference, drawing on key contemporary research to provide an in-depth, international, and competencies-based approach to the psychology of coaching and mentoring. Puts cutting-edge evidence at the fingertips of organizational psychology practitioners who need it most, but who do not always have the time or resources to keep up with scholarly research Thematic chapters cover theoretical models, efficacy, ethics, training, the influence of emerging fields such as neuroscience and mindfulness, virtual coaching and mentoring and more Contributors include Anthony Grant, David Clutterbuck, Susan David, Robert Garvey, Stephen Palmer, Reinhard Stelter, Robert Lee, David Lane, Tatiana Bachkirova and Carol Kauffman With a Foreword by Sir John Whitmore

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Автор: Alister E. McGrath

This fourth edition of the international bestseller is the ideal introduction for those who are new to Christian theology. In this revised and expanded edition, the author introduces readers to the central ideas and beliefs, the key debates and the leading thinkers of Christianity. Throughout, the aim is to bring clarity and brevity to the central ideas of theology, both traditional and contemporary. The text comprehensively covers the individual doctrines that form the Christian belief system, weaving together these doctrines, their history, and the intellectual nuance behind them into an inter-connected web. All major Christian denominations are explored, as are their differences and shared customs and beliefs. This rich tapestry results in a clear view of Christianity, providing a coherent vision of the religion in its main forms.

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Автор: Bolton Hall

libreka classics – These are classics of literary history, reissued and made available to a wide audience. Immerse yourself in well-known and popular titles!

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Автор: John Booss

Expert storytellers weave together the science, technological advances, medical urgencies, and human stories that chronicle the development of the field of diagnostic virology. Follows a historical discoveries that defined viruses and their roles in infectious diseases over a century of developments, epidemics, and molecular advances, and continuing into the 21st century with AIDS, HIV, and a future that in no way resembles the past. Features the great names and personalities of diagnostic virology, their contributions, their associations, and their challenges to prove findings that some considered fantasy. Describes how scientists applied revolutionary technologies, studying viruses, first in animal models and tissue culture and progressing to molecular and genetic techniques. Appeals to the pioneer and adventure-seeker who is interested in how a scientific field evolves.

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Автор: Андрей Тихомиров

Il est scientifiquement prouv? que l'homme est un singe mut? (Homo sapiens) et que les parents les plus proches de nous dans le g?nome d?cod? sont les primates. Tout le reste (cr?ationnisme, «?lection» de certains peuples) n'est rien de plus que de l'auto-tromperie. L'homme, tout comme les autres ?tres, n'est pas apparu ? la suite des actions des «forces divines», mais seulement par des mutations, des changements g?n?tiques.

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Автор: Группа авторов

This book demonstrates that trade-offs can be very important for conservationists. Its various chapters show how and why trade-offs are made, and why conservationists need to think very hard about what, if anything, to do about them. The book argues that conservationists must carefully weigh up, and be explicit about, the trade-offs that they make every day in deciding what to save. Key Features: Discusses the wider non-biological issues that surround making decisions about which species and biogeographic areas to prioritise for conservation Focuses on questions such as: What are these wider issues that are influencing the decisions we make? What factors need to be included in our assessment of trade-offs? What package of information and issues do managers need to consider in making a rational decision? Who should make such decisions? Part of the Conservation Science and Practice book series This volume is of interest to policy-makers, researchers, practitioners and postgraduate students who are concerned about making decisions that include recognition of trade-offs in conservation planning.

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Автор: Группа авторов

The first complete overview of progress in the field. The two volumes contain selected articles from the prestigious online Encyclopedia of Molecular Cell Biology and Molecular Medicine, fully updated and enriched with numerous new contributions from many eminent scientists. Divided into three parts, the first gives a thorough introduction to cancer biology, while Part Two covers therapeutic approaches for all major forms of cancer, and the third part deals with cancer diagnostics. The result is a one-stop resource for advanced students, postdoctoral researchers and start-up companies.

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Автор: Группа авторов

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

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Автор: Irwin W. Sherman

Covers the history of twelve important diseases and addresses public health responses and societal upheavals. Chronicles the ways disease outbreaks shaped traditions and institutions of Western civilization. Explains the effects, causes, and outcomes from past epidemics. Describes a dozen diseases to show how disease control either was achieved or failed. Makes clear the interrelationship between diseases and history. Presents material in a compelling, clear, and jargon-free prose for a wide audience. Provides a picture of the best practices for dealing with disease outbreaks.

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Автор: Коллектив авторов

Сборник, посвященный памяти известного российского зоолога Я.И. Старобогатова, обобщает достижения отечественных ученых в решении ряда общебиологических теоретических и прикладных проблем. Включены статьи, посвященные двустворчатым и брюхоногим моллюскам. Дан критический анализ использования Я.И. Старобогатовым «биологической концепции вида» в приложении к пресноводным моллюскам. Освещается роль биотических и экосистемных и ландшафтных подходов к пространственной оценке водных и наземных биоресурсов. Приводятся ранее не публиковавшаяся работа Я.И. Старобогатова и полный список его научных и научно-популярных публикаций. Изложенные в статьях выводы представляют хорошую теоретическую основу для изучения закономерностей формирования и для рационального использования биоресурсов России. Представляет интерес для биологов разного профиля, преподавателей вузов, студентов и широкого круга читателей, интересующихся проблемой.

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Автор: Ronald A. Hites

Ein schneller Einstieg in die Umweltchemie, fachlich fundiert und mit Praxisbezug? Die vorliegende Ubersetzung des amerikanischen Bestsellers Elements of Environmental Chemistry macht es moglich. Hier werden die Schwerpunkte der Umweltchemie auf den Punkt gebracht: Welche Faktoren verursachen die Klimaerwarmung? Wo nutzt Ozon und wo schadet es? Wie verhalten sich schwer abbaubare Substanzen, wenn sie in die Umwelt gelangen? Erganzt um aktuelle Beispiele aus Deutschland und Europa vermittelt das einfuhrende Lehrbuch Grundlagen und Anwendungen des chemischen Verhaltens von Stoffen in der Umwelt. Zahlreiche Beispielrechnungen trainieren den Umgang mit chemischen Gro?en. Den Bezug zur Praxis stellen die uber 150 Ubungsaufgaben her, und der Lernerfolg kann gleich im Losungsteil uberpruft werden. Ein Grundlagenbuch und ein Werkzeugkasten, der Bachelor-Studenten mit dem notwendigen Wissen ausrustet. Das ideale Einsteigerbuch fur Studierende aller Fachrichtungen.

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Автор: John E. A. Bertram

Understanding Mammalian Locomotion will formally introduce the emerging perspective of collision dynamics in mammalian terrestrial locomotion and explain how it influences the interpretation of form and functional capabilities. The objective is to bring the reader interested in the function and mechanics of mammalian terrestrial locomotion to a sophisticated conceptual understanding of the relevant mechanics and the current debate ongoing in the field.

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Автор: Группа авторов

Recently, UNESCO has gradually started to recognize world geoparks ? territorial spaces with a geological heritage of international importance. This classification presents real challenges. Development strategies must align with the recommendations advocated by various non-governmental organizations. It is also necessary to involve the local actors, both in the preparation of application forms and in the implementation of a management plan that is suitable for sustainable global development. Managing the tensions and asymmetries that exist between the different groups of actors (politicians, managers, scientists, representatives of local populations) constitutes another major issue. It is in this context and through various case studies that this book questions the aims of the UNESCO global geoparks ? in terms of heritage inventory and conservation, the participation of local populations, the local development of a territory and its enhancement through heritage interpretation.

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