физическая химия

Автор: Группа авторов

«Юность» – советский, затем российский литературно-художественный иллюстрированный журнал для молодёжи. Выходит в Москве с 1955 года.

Серия: Журнал «Юность» 2019

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Автор: С. М. Дробышевский

Работа посвящена проверке стандартных гипотез относительно поведения показателей, характеризующих временную структуру процентных ставок на российском рынке ГКО-ОФЗ, выявлению и анализу произошедших в период между кризисами (1998–2008 гг.) изменений во временной структуре процентных ставок, их реакции на трансформацию макроэкономических показателей в 1999–2008 гг.

Серия: Научные труды. Институт экономической политики имени Е. Т. Гайдара

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Автор: Е. В. Малышева

Сборник задач представляет собой комплекс заданий, позволяющий студенту оптимальным образом организовать процесс подготовки к практическому занятию, содержит план практических занятий, краткий теоретический материал, задачи и тестовые задания для решения на практических занятиях, а также списки вопросов для размышления.

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Автор: Е. А. Василенко

В статье проанализированы существующие открытые объектно-ориентированные системы, которые можно использовать в качестве среды для разработки и размещения электронных информационно-образовательных ресурсов, в том числе и для дистанционного обучения. Обоснована необходимость использования модульной объектно-ориентированной среды Moodle для создания учебного портала РХТУ им. Д. И. Менделеева (http://moodle.muctr.ru). В работе рассмотрены возможности Moodle для разработки электронных информационно-образовательных ресурсов и описаны разработанные обучающие материалы по дисциплинам «Информационные технологи в химии» и «Защита интеллектуальной собственности» в соответствии с учебным планом подготовки студентов химиков-технологов.

Серия: Прикладная информатика. Научные статьи

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Автор: З. Х. Сергеева

В работе рассматриваются сложные процессы развития и функционирования нефтяной отрасли. Автор выделил и проанализировал ключевые этапы в истории становления мировой нефтяной отрасли. В книге также показано, что в XX в. развитие общества обусловлено беспрецедентным ростом энергопотребления в целом, а также углеводородов в частности.

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Автор: Е. А. Кирсанов

Неньютоновское поведение структурированных систем проявляется в изменении вязкости при изменении скорости сдвигового течения. Структурная реологическая модель объясняет явление неньютоновского течения в суспензиях, эмульсиях, мицеллярных растворах, растворах и расплавах полимеров, а также в жидких кристаллах. Полученные реологические уравнения описывают вязкость и силы упругости при стационарном течении, вязкие и упругие характеристики при сдвиговых колебаниях. Структурный подход является альтернативой классической теории вязкоупругости и связывает изменение вязкости с изменением структуры вещества. Коэффициенты полученных уравнений прямо связаны со структурой и физико-химическими свойствами структурированных систем. Рассмотрены практически важные системы: полимеры и композитные материалы, нефть и буровые растворы, тиксотропные красители и кровь. Книга может быть полезной для ученых и специалистов в области физикохимии дисперсных систем, коллоидной химии и физикохимии полимеров, медицины.

Серия: Мир химии

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Автор: А. Н. Игнатов

Рассматриваются история и технологические основы электроники, свойства химических элементов и их соединений, основные технологические процессы микро- и наноэлектроники, основные виды нанотехнологий и их изделий, а также нанотехнологическое оборудование. Для студентов всех форм обучения по направлениям: 11.03.01 «Радиоэлектроника», 11.03.02 «Инфокоммуникационные технологии и системы связи», 11.03.03 «Конструирование и технология электронных средств», 11.03.04 «Электроника и наноэлектроника», а также учащихся колледжей электронного и радиотехнического профилей.

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Автор: Alexandra Bolena

Sie wollen mit Ihren Geldgesch?ften die Welt ein bisschen besser machen? Ihr Erspartes in Unternehmen mit einer nachhaltigen Gesch?ftsidee investieren, die umweltfreundlich und fair wirtschaften und vielleicht sogar noch soziale Projekte unterst?tzen? Dieses Buch gibt Ihnen Tipps f?r die Auswahl von nachhaltigen Aktien, Anleihen, ESG-konformen Fonds und ETFs. Dar?ber hinaus gibt es f?r Sie als nachhaltig orientierten Anleger aber noch eine Vielzahl anderer innovativer M?glichkeiten, Ihr Geld «gut» anzulegen: Lesen Sie alles ?ber Green und Social Bonds, Investments in nachhaltige Sachwerte, Mikrofinanz oder Crowdinvesting und warum eines dieser Themen sicher auch zu Ihren Vorstellungen passt. Erfahren Sie, wie Sie echte nachhaltige Angebote von solchen, die «Green-washing» betreiben, unterscheiden, warum die SDGs eine gute Messlatte sind, was G?tesiegel aussagen und last but not least warum auch Ihre Hausbank einen Beitrag leisten kann und wie Sie dieser in Sachen Nachhaltigkeit auf den Zahn f?hlen k?nnen.

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Автор: Janet Driscoll Miller

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Автор: Liz Palika

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Автор: John T. Moore

It’s alive! It’s alive! (Thanks to biochemistry, that is.)  Biochemistry is the science of the chemical processes that allow for…well…life. If it moves, breathes, eats, or sleeps, biochemistry can probably explain how. So, it stands to reason that the fundamentals of biochemistry can get a little complicated.  In  Biochemistry For Dummies,  you’ll explore the carbons, proteins, and cellular systems that make up the biochemical processes that create and sustain life of all kinds. Perfect for students majoring in biology, chemistry, pre-med, health-services, and other science-related fields, this book tracks a typical college-level biochemistry class. It simplifies and clarifies the subject with easy-to-follow diagrams and real-world examples. You’ll also get:  Explorations of cell biology, carbohydrates, proteins, lipids, and other fundamental building blocks of life Discussions of the basic structures common to all living organisms Treatments of the microscopic details of life that make us all tick If you’re looking for a hand with some of the trickier parts of biochemistry—or you just need an accessible overview of the subject—check out  Biochemistry For Dummies  today!

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Автор: Steven M. Rice

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Автор: Sarah Werner

A comprehensive resource to understanding the hand-press printing of early books Studying Early Printed Books, 1450 – 1800 offers a guide to the fascinating process of how books were printed in the first centuries of the press and shows how the mechanics of making books shapes how we read and understand them. The author offers an insightful overview of how books were made in the hand-press period and then includes an in-depth review of the specific aspects of the printing process. She addresses questions such as: How was paper made? What were different book formats? How did the press work? In addition, the text is filled with illustrative examples that demonstrate how understanding the early processes can be helpful to today’s researchers. Studying Early Printed Books shows the connections between the material form of a book (what it looks like and how it was made), how a book conveys its meaning and how it is used by readers. The author helps readers navigate books by explaining how to tell which parts of a book are the result of early printing practices and which are a result of later changes. The text also offers guidance on: how to approach a book; how to read a catalog record; the difference between using digital facsimiles and books in-hand. This important guide: Reveals how books were made with the advent of the printing press and how they are understood today Offers information on how to use digital reproductions of early printed books as well as how to work in a rare books library Contains a useful glossary and a detailed list of recommended readings Includes a companion website for further research Written for students of book history, materiality of text and history of information, Studying Early Printed Books explores the many aspects of the early printing process of books and explains how their form is understood today.

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Автор: Группа авторов

This collection of essays in Governing Global Land Deals provides new empirical and theoretical analyses of the relationships between global land grabs and processes of government and governance. Reframes debates on global land grabs by focusing on the relationship between large-scale land deals and processes of governance Offers new theoretical insights into the different forms and effects of global land acquisitions Illuminates both the micro-processes of transaction and expropriation, as well as the broader structural forces at play in global land deals Provides new empirical data on the different actors involved in contemporary land deals occurring across the globe and focuses on the specific institutional, political, and economic contexts in which they are acting

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Автор: B. Kim Barnes

Change minds, guide opinions, and shape emotions with the power of effective influence Exercising Influence is your guide to accomplishing more with less effort. Demystifying the process of influencing others, this book shows you how to develop effective influence behaviors, plan an influence approach, set goals, resolve problems, and build better relationships. Revised and expanded to provide more actionable advice across industries and sectors, this third edition has updated examples and resources and features all-new chapters on influencing through social media, influencing your team, and applying research findings of neuroscience, and behavioral economics.. You'll create work, family, and community relationships that are more mutually rewarding as you apply a practical, real-world model for developing this seldom-taught skill. Influence is a skillset that everyone needs, yet the necessary techniques and fundamentals are rarely made explicit and shared. This book is a vital resource for anyone who wants to achieve better outcomes at work, at home, or in the world at large, helping you make important things happen and create relationships that matter. Develop a strategic and tactical approach to influence that gets results. Resolve problems and conflicts, and build more balanced relationships. Do more with less, increase your impact on others, and take greater charge of your life. Take advantage of new methodologies that build your skills as an influencer. Influence is a timeless topic for business leaders and others in positions of power, but the world has evolved to the point where everyone needs these skills. No matter your job, role, rank, or function, if you want to get things done you need to know how to influence up, down, across, and outside the organization. With improved skills, you can steer opinions, impact decisions, and sway the undecided. If you're ready to see what you're capable of, Exercising Influence will show you how to take charge of your professional and personal life in a powerful, ethical, and productive way. http://www.wiley.com/WileyCDA/WileyTitle/productCd-1119071585.html

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Автор: John C. Cavadini

The definitive compendium of Cavadini’s essays on Augustine Visioning Augustine offers readers an expertly selected collection of essays exploring the text and history of the theology of Saint Augustine. Prominent scholar and essayist, John Cavadini, offers modern audiences an innovative framework for understanding Augustine, integrating articles and essays on significant texts, historical and contemporary perspectives and insights into Augustine’s development as a theologian. Examining themes such as the transformation of the human will in De doctrina Christiana and Augustine’s critique of philosophy in City of God, Cavadini provides clear and accessible smaller-size essays that serve as entry points for those interested in Augustinian scholarship. The author’s meditations on Augustinian texts invite readers to re-evaluate their interpretations and learn about the subtle and sophisticated vocabulary of Augustine. An encounter with Augustine the Christian theologian, Cavadini contends, is not a narrowly focused parochial experience, but instead a challenge to enlarge our horizons. Written by one of the most prominent Augustinian scholars and essayists in the field Addresses ecumenical and cultural issues that weaken contemporary interest in Christian faith Offers modern readers historical context on Augustinian theology Provides a single-volume collection of Cavadini’s essays on Augustine written over the course of more than two decades Accessible prose and intellectual sensitivity to modern theological problemsmake Visioning Augustine an indispensable volume for graduate students, scholars and professionals in all areas of Christian theology.

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Автор: Michael Braun

In mechanical engineering the trend towards increasingly flexible solutions is leading to changes in control systems. The growth of mechatronic systems and modular functional units is placing high demands on software and its design. In the coming years, automation technology will experience the same transition that has already taken place in the PC world: a transition to more advanced and reproducible software design, simpler modification, and increasing modularity. This can only be achieved through object-oriented programming. This book is aimed at those who want to familiarize themselves with this development in automation technology. Whether mechanical engineers, technicians, or experienced automation engineers, it can help readers to understand and use object-oriented programming. From version 4.5, SIMOTION provides the option to use OOP in accordance with IEC 61131-3 ED3, the standard for programmable logic controllers. The book supports this way of thinking and programming and offers examples of various object-oriented techniques and their mechanisms. The examples are designed as a step-by-step process that produces a finished, ready-to-use machine module. Contents: Developments in the field of control engineering – General principles of object-oriented programming – Function blocks, methods, classes, interfaces – Modular software concepts – Object-oriented design, reusable and easy-to-maintain software, organizational and legal aspects, software tests – I/O references, namespaces, general references – Classes in SIMOTION, instantiation of classes and function blocks, compatible and efficient software – Introduction to SIMOTION and SIMOTION SCOUT.

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Автор: Paul Wicker

Rapid Perioperative Care is an essential text for students and practitioners requiring up-to-date fundamental information on the perioperative environment. Covering a wide range of subjects related to perioperative practice and care, each chapter is concise and focused to guide the reader to find information quickly and effectively. This book uses a structured approach to perioperative care, starting with an introduction to the perioperative environment, anaesthetics, surgery and recovery, followed by postoperative problems and finally the roles of the Surgical Care Practitioner (SCP). Covering all the key topics in the perioperative environment, this concise and easy-to-read title is the perfect quick-reference book for students and theatre practitioners to support them in their work in clinical practice, and enable them to deliver the best possible care.

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Автор: George Ritzer

An accessible and comprehensive introduction to key concepts in globalization written by leading authors in the field  In the comprehensively revised Third Edition of  Globalization: A Basic Text , distinguished researchers and authors George Ritzer and Paul Dean deliver an up-to-date introduction to major trends and topics related to the study of globalization. The book includes accessible and rigorous material on the key theories and major topics in globalization, as well as modern developments like the rise of populism and far-right political groups, Brexit, migration and backlash to it, trade negotiations, social media and the spread of misinformation, climate change, social justice issues, and COVID-19.  The new edition includes a greater focus on the structures of inequality that encourage or discourage global flows. Additionally, new examples and sources from Central and South America, Africa, and Asia are used to illustrate key concepts, and round out the international coverage of book. Throughout, the authors use clear and helpful metaphors including solids, liquids, gases, and flows to introduce and explain the complex nature of globalization in an engaging and understandable way.  Readers will also benefit from the inclusion of:  A thorough introduction to globalization and related processes, including imperialism, colonialism, development, and westernization An exploration of neoliberalism, including its roots, principles, criticisms, and Neo-Marxist alternatives A practical discussion of global political structures and processes, as well as global economic flows of production and consumption A concise treatment of negative global flows and processes, including dangerous imports, diseases, crime, terrorism, and war Analysis of the changing nature of globalization and de-globalization, and the social movements and technological developments driving these changes More images, charts, and graphs to help illustrate and highlight the concepts contained in the book Perfect for advanced undergraduates studying globalization across sociology, political science, geography, anthropology, and economics,  Globalization: A Basic Text, Third Edition  will also be essential reading for students taking courses in culture, economy and inequality, and migration taught from a global perspective.

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Автор: Группа авторов

The thoroughly revised Women in Culture 2/e explores the intersections of gender, race, sexuality, gender identity, and spirituality from the perspectives of diverse global locations. Its strong humanities content, including illustrations and creative writing, uniquely embraces the creative aspects of the field. Each of the ten thematic chapters lead to creative readings, introducing a more Readings throughout the text encourage intersectional thinking amongst students humanistic angle than is typical of textbooks in the field This textbook is queer inclusive and allows students to engage with postcolonial/decolonial thinking, spirituality, and reproductive/environmental justice A detailed timeline of feminist history, criticism and theory is provided, and the glossary encourages the development of critical vocabulary A variety of illustrations supplement the written materials, and an accompanying website offers instructors pedagogical resources

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Автор: Hassan Radoine

Architecture in Context: Designing in the Middle East provides a foundation for understanding the critical context of architecture and design in this region. It does this by: presenting a practical overview of architectural know-how in the Middle East, and its potential for cultivating a sense of place introducing local architectural vocabularies and styles, and how they can still be reactivated in contemporary design exploring the cultural and contextual meaning of forms as references that may influence contemporary architecture discussing important discourses and trends in architecture that allow a rethinking of the current global/local dichotomy. Highly illustrated, the book covers architecture and design in North Africa, the Levant, the Gulf, and Turkey, Iran and Iraq.

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Автор: Andrew Rolle

The eighth edition of California: A History covers the entire scope of the history of the Golden State, from before first contact with Europeans through the present; an accessible and compelling narrative that comprises the stories of the many diverse peoples who have called, and currently do call, California home. Explores the latest developments relating to California’s immigration, energy, environment, and transportation concerns Features concise chapters and a narrative approach along with numerous maps, photographs, and new graphic features to facilitate student comprehension Offers illuminating insights into the significant events and people that shaped the lengthy and complex history of a state that has become synonymous with the American dream Includes discussion of recent – and uniquely Californian – social trends connecting Hollywood, social media, and Silicon Valley – and most recently «Silicon Beach»

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Автор: Peter Kl?fers

Mit dieser Einfuhrung in die faszinierende Welt der Metalloproteine lernen Chemiker, Biochemiker und Biotechnologen Mechanismen, Methoden und Modellvorstellungen der bioanorganischen Chemie kennen. In einer Synthese aus aktuellen Arbeiten an Metalloenzymzentren und den Grundlagen der Koordinationschemie fuhren die Autoren in dieses spannende und im Wortsinne komplexe Thema ein. Der erste Teil des Buches stellt anhand ausgewahlter Metalloproteine dar, dass die Natur die koordinationschemischen Prinzipien «kennt» und in einer Weise nutzt, die vorbildhaft fur die Entwicklung synthetischer Katalysatoren sein kann. Einige der verwendeten Konzepte werden in Einschuben naher beleuchtet. Der zweite Teil vermittelt die Grundlagen der verschiedenen instrumentellen Methoden fur die Untersuchung von Metalloproteinen, von der Kristallographie uber die Vielfalt an spektroskopischen Methoden (UV, Raman, Fluoreszenz, EPR, Mo?bauer etc.) bis hin zu elektrochemischen und computerchemischen Methoden. Durch die Betonung der koordinationschemischen Grundlagen biochemischer Funktion ist dieses Lehrbuch eine wichtige Erganzung zu den Standardlehrbuchern der Biochemie und der anorganischen Chemie. Der modulare Aufbau erleichtert dabei den Einsatz fur unterschiedliche Lehrveranstaltungen und Studiengange.

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Автор: Mark Karlen

Conquer the complexity of interior design with a logical, methodical approach Space Planning Basics is a definitive introduction and principle resource for thousands of designers. With step-by-step methodology based on the author’s several decades of design experience, this authoritative guide has become the de facto reference for an entire generation of designers. This updated fourth edition includes digitized drawings, diagrams, and matrices throughout, and newly added supplemental photographs. The text has been revised to reflect the latest developments in sustainable and universal design, including coverage of daylighting, benchmarking, LEED system standards, and green code issues. The companion website provides AutoCAD files, intrustor videos and matrices to give you a deeper real-world understanding of the design process. This book is perfect preparation for the NCIDQ exam. Proper space planning goes way beyond sketching a preliminary floor plan. Successful implementation includes a balanced integration of code compliance, system support, and adherence to the client’s functional needs. Sustainability adds a new, important layer of complexity. This book shows you how to approach space planning in a way that ensures all considerations are met, and nothing gets lost in the process. Adopt an organized and comprehensive planning methodology Work effectively with dimensionally challenging spaces Consider building systems, codes, lighting, acoustics, and more Develop advanced skills and conquer new challenges Space planning encompasses many components and processes, making a comprehensive reference necessary for mastery of the field. Space Planning Basics is a thorough, methodical resource that gets you started on the right track, with plenty of room for creativity.

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Автор: Joseph J. Provost

Written as a textbook with an online laboratory manual for students and adopting faculties, this work is intended for non-science majors / liberal studies science courses and will cover a range of scientific principles of food, cooking and the science of taste and smell. Chapters include: The Science of Food and Nutrition of Macromolecules; Science of Taste and Smell; Milk, Cream, and Ice Cream, Metabolism and Fermentation; Cheese, Yogurt, and Sour Cream; Browning; Fruits and Vegetables; Meat, Fish, and Eggs; Dough, Cakes, and Pastry; Chilies, Herbs, and Spices; Beer and Wine; and Chocolate, Candy and Other Treats. Each chapters begins with biological, chemical, and /or physical principles underlying food topics, and a discussion of what is happening at the molecular level. This unique approach is unique should be attractive to chemistry, biology or biochemistry departments looking for a new way to bring students into their classroom. There are no pre-requisites for the course and the work is appropriate for all college levels and majors.

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Автор: Charles E. Schaefer

An integrative approach to play therapy blending various therapeutic treatment models and techniques Reflecting the transition in the field of play therapy from a «one size fits all» approach to a more eclectic framework that integrates more than one perspective, Integrative Play Therapy explores methods for blending the best theories and treatment techniques to resolve the most common psychological disorders of childhood. Edited by internationally renowned leaders in the field, this book is the first of its kind to look at the use of a multi-theoretical framework as a foundation for practice. With discussion of integrative play treatment of children presenting a wide variety of problems and disorders—including aggression issues, the effects of trauma, ADHD, anxiety, obsessive-compulsive disorders, social skills deficits, medical issues such as HIV/AIDS, and more—the book provides guidance on: Play and group therapy approaches Child-directed play therapy with behavior management training for parents Therapist-led and child-led play therapies Cognitive-behavioral therapy with therapeutic storytelling and play therapy Family therapy and play therapy Bibliotherapy within play therapy An essential resource for all mental health professionals looking to incorporate play therapy into treatment, Integrative Play Therapy reveals unique flexibility in integrating theory and techniques, allowing practitioners to offer their clients the best treatment for specific presenting problems.

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Автор: Ceri Davies

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Автор: Группа авторов

The analysis of plants, insects, soil and other particulates from scenes of crime can be vital in proving or excluding contact between a suspect and a scene, targeting search areas, and establishing a time and place of death. Forensic Ecology: A Practitioner’s Guide provides a complete handbook covering all aspects of forensic ecology. Bringing together the forensic applications of anthropology, archaeology, entomology, palynology and sedimentology in one volume, this book provides an essential resource for practitioners in the field of forensic science, whether crime scene investigators, forensic science students or academics involved in the recovery and analysis of evidence from crime scenes. Forensic Ecology: A Practitioner’s Guide includes information not only on the search, location, recovery and analysis of evidence, but includes sampling strategies for diatom analysis, pollen and soils samples and entomology and provides guides for good practice. Each chapter provides background information on each discipline and is structured according to pre-scene attendance (what questions should the scientist ask when receiving a call? What sort of preparation is required?), scene attendance (including protocols at the scene, sampling strategies, recording), scientific examination of analysis of the evidence up to the stages and guidelines for witness statement and presenting evidence in court. The book is written by specialists in all fields with a wealth of experience who are current forensic practitioners around the world. It provides an essential and accessible resource for students, academics, forensic practitioners and police officers everywhere.

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Автор: James C. Dabrowiak

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

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Автор: Anthony K. Campbell

The definitive text on the key component for cell functions—intracellular calcium This comprehensive book reveals the evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells. It shows how the components required for calcium signaling are named and classified; covers the technology that has been developed to study intracellular calcium; describes how calcium is regulated inside cells and how it works to trigger an event; explains the role of intracellular calcium in disease, cell injury, and cell death; reveals how many drugs work through the calcium signaling system; and demonstrates how intracellular calcium is involved in the action of many natural toxins. The book also illustrates how the intracellular calcium signaling system has evolved over millions of years, showing why it was crucial to the origin of life. Additionally, the book promotes the importance of the molecular variation upon which the intracellular calcium signalling system depends. Featuring more than 100 figures (including detailed chemical structures as well as pictures of key pioneers in the field), a bibliography of some 1000 references, and a detailed subject index, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond. Emphasizes two key scientific principles—the first to show how intracellular Ca2+ acts as a switch, to activate a wide range of cellular events, and the second demonstrating how an analogue mechanism can be superimposed on such a process Written by an internationally recognized expert in the field Filled with images and references to facilitate learning Fundamentals of Intracellular Calcium is an all-important text for post-graduate students and researchers working in biomedicine and biochemistry. It is also essential for undergraduate lecturers and their students in physiology, medicine, pharmacy, and the biosciences.

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Автор: Daniel Lednicer

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

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Автор: Andrea Bellelli

Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experiments Applies historical and physical insight to provide a clear understanding of ligand binding Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.

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Автор: Rama K. Yedavalli

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Автор: Группа авторов

Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.

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Автор: Antonio A. Munjiza

Mechanics of Discontinua is the first book to comprehensively tackle both the theory ofthis rapidly developing topic and the applications that span a broad field of scientific and engineering disciplines, from traditional engineering to physics of particulates, nano-technology and micro-flows. Authored by a leading researcher who has been at the cutting edge of discontinua simulation developments over the last 15 years, the book is organized into four parts: introductory knowledge, solvers, methods and applications. In the first chapter a short revision of Continuum Mechanics together with tensorial calculus is introduced. Also, a short introduction to the finite element method is given. The second part of the book introduces key aspects of the subject. These include a diverse field of applications, together with fundamental theoretical and algorithmic aspects common to all methods of Mechanics of Discontinua. The third part of the book proceeds with the most important computational and simulation methods including Discrete Element Methods, the Combined Finite-Discrete Element Method, Molecular Dynamics Methods, Fracture and Fragmentation solvers and Fluid Coupling. After these the reader is introduced to applications stretching from traditional engineering and industry (such as mining, oil industry, powders) to nanotechnology, medical and science.

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Автор: Группа авторов

The first book to provdie a comprehensive look at bioenergetics, the energy flow in living systems, by studying ion exchange and electron transfer processes in biological membranes and artificial bio-films, and how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells. The book: Discusses the ion fluxes and electron transfer processes in biological membranes and artificial bio-films Provides an in-depth description of the processes at the interface between the membrane/film and substrate electrode Is the first of its kind to provide a comprehensive look at how these processes are understood in biology of living cells Addresses how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells

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Автор: Группа авторов

A unique discussion of mathematical methods with applications to quantum mechanics Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects presents various mathematical constructions influenced by quantum mechanics and emphasizes the spectral theory of non-adjoint operators. Featuring coverage of functional analysis and algebraic methods in contemporary quantum physics, the book discusses the recent emergence of unboundedness of metric operators, which is a serious issue in the study of parity-time-symmetric quantum mechanics. The book also answers mathematical questions that are currently the subject of rigorous analysis with potentially significant physical consequences. In addition to prompting a discussion on the role of mathematical methods in the contemporary development of quantum physics, the book features: Chapter contributions written by well-known mathematical physicists who clarify numerous misunderstandings and misnomers while shedding light on new approaches in this growing area An overview of recent inventions and advances in understanding functional analytic and algebraic methods for non-selfadjoint operators as well as the use of Krein space theory and perturbation theory Rigorous support of the progress in theoretical physics of non-Hermitian systems in addition to mathematically justified applications in various domains of physics such as nuclear and particle physics and condensed matter physics An ideal reference, Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects is useful for researchers, professionals, and academics in applied mathematics and theoretical and/or applied physics who would like to expand their knowledge of classical applications of quantum tools to address problems in their research. Also a useful resource for recent and related trends, the book is appropriate as a graduate-level and/or PhD-level text for courses on quantum mechanics and mathematical models in physics.

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Автор: Charles C. Hong

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies. In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. This volume provides an essential overview of this emerging technology for researchers in academic, industrial and clinical environments working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering. It is appropriate for training students and newcomers to the field, benefitting readers in broadening their knowledge and giving them insights to regenerative chemical biology, as well as encouraging readers to implement the key points in their own fields of study to develop new technologies.

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Автор: Joseph J. Stephanos

Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

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Автор: Hans Bisswanger

Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.

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Автор: Gerhard Krauss

Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere. Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on «the Krauss» to find their way through the bewildering complexity of biological signaling pathways.

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Автор: Zbigniew J. Witczak

Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.

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Автор: Группа авторов

Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.

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Автор: Pedro Merino

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.

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Автор: Группа авторов

This useful, one-stop resource for understanding the most important issues in materials challenges in alternative and renewable energy. The logically organized and carefully selected articles give insight into materials challenges in alternative renewable energy and incorporate the latest developments related to materials challenges in alternative renewable energy, including hydrogen, batteries and energy storage materials, hydropower, and biomass.

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Автор: Группа авторов

This revised edition of A History of Old English Literature draws extensively on the latest scholarship to have evolved over the last decade. The text incorporates additional material throughout, including two new chapters on Anglo-Saxon manuscripts and incidental and marginal texts. This revised edition responds to the renewed historicism in medieval studies Provides wide-ranging coverage, including Anglo-Latin literature as well as non-canonical writings Includes new chapters on manuscripts and on marginal and incidental texts Incorporates expanded coverage of legal texts and scientific and scholastic texts, now treated in separate chapters Demonstrates that the field of Anglo-Saxon studies is uniquely placed to contribute to current literary debates

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Автор: Zigang Li

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Автор: Группа авторов

In Volume XV in the series «Advances in Electrochemical Science and Engineering» various leading experts from the field of electrochemical engineering share their insights into how different experimental and computational methods are used in transferring molecular-scale discoveries into processes and products. Throughout, the focus is on the engineering problem and method of solution, rather than on the specific application, such that scientists from different backgrounds will benefit from the flow of ideas between the various subdisciplines. A must-read for anyone developing engineering tools for the next-generation design and control of electrochemical process technologies, including chemical, mechanical and electrical engineers, as well as chemists, physicists, biochemists and materials scientists.

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Автор: Группа авторов

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Автор: Naoki Sugimoto

Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

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Автор: Naoki Sugimoto

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