физическая химия

Автор: А. Н. Игнатов

Рассматриваются история и технологические основы электроники, свойства химических элементов и их соединений, основные технологические процессы микро- и наноэлектроники, основные виды нанотехнологий и их изделий, а также нанотехнологическое оборудование. Для студентов всех форм обучения по направлениям: 11.03.01 «Радиоэлектроника», 11.03.02 «Инфокоммуникационные технологии и системы связи», 11.03.03 «Конструирование и технология электронных средств», 11.03.04 «Электроника и наноэлектроника», а также учащихся колледжей электронного и радиотехнического профилей.

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This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development

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A unique discussion of mathematical methods with applications to quantum mechanics Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects presents various mathematical constructions influenced by quantum mechanics and emphasizes the spectral theory of non-adjoint operators. Featuring coverage of functional analysis and algebraic methods in contemporary quantum physics, the book discusses the recent emergence of unboundedness of metric operators, which is a serious issue in the study of parity-time-symmetric quantum mechanics. The book also answers mathematical questions that are currently the subject of rigorous analysis with potentially significant physical consequences. In addition to prompting a discussion on the role of mathematical methods in the contemporary development of quantum physics, the book features: Chapter contributions written by well-known mathematical physicists who clarify numerous misunderstandings and misnomers while shedding light on new approaches in this growing area An overview of recent inventions and advances in understanding functional analytic and algebraic methods for non-selfadjoint operators as well as the use of Krein space theory and perturbation theory Rigorous support of the progress in theoretical physics of non-Hermitian systems in addition to mathematically justified applications in various domains of physics such as nuclear and particle physics and condensed matter physics An ideal reference, Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects is useful for researchers, professionals, and academics in applied mathematics and theoretical and/or applied physics who would like to expand their knowledge of classical applications of quantum tools to address problems in their research. Also a useful resource for recent and related trends, the book is appropriate as a graduate-level and/or PhD-level text for courses on quantum mechanics and mathematical models in physics.

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Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.

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Baking is a process that has been practiced for centuries, and bakery products range in complexity from the simple ingredients of a plain pastry to the numerous components of a cake. While currently there are many books available aimed at food service operators, culinary art instruction and consumers, relatively few professional publications exist that cover the science and technology of baking. In this book, professionals from industry, government and academia contribute their perspectives on the state of industrial baking today. The second edition of this successful and comprehensive overview of bakery science is revised and expanded, featuring chapters on various bread and non-bread products from around the world, as well as nutrition and packaging, processing, quality control, global bread varieties and other popular bakery products. The book is structured to follow the baking process, from the basics, flour and other ingredients, to mixing, proofing and baking. Blending the technical aspects of baking with the latest scientific research, Bakery Products Science and Technology, Second Edition has all the finest ingredients to serve the most demanding appetites of food science professionals, researchers, and students.

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Автор: Группа авторов

A fully revised review of the latest research in molecular basis of plant abiotic stress response and adaptation Abiotic stressors are non-living environmental stressors that can have a negative impact on a plants ability to grow and thrive in a given environment. Stressors can range from temperature stress (both extreme heat and extreme cold) water stress, aridity, salinity among others. This book explores the full gamut of plant abiotic stressors and plants molecular responses and adaptations to adverse environmental conditions. The new edition of Plant Abiotic Stress provides up-to-date coverage of the latest research advances in plant abiotic stress adaptation, with special emphasis on the associated and integrative aspects of physiology, signaling, and molecular-genetics. Since the last edition, major advances in whole genome analysis have revealed previously unknown linkages between genes, genomes, and phenotypes, and new biological and –omics approaches have elucidated previously unknown cellular mechanisms underlying stress tolerance. Chapters are organized by topic, but highlight processes that are integrative among diverse stress responses. As with the first edition, Plant Abiotic Stress will have broad appeal to scientists in fields of applied agriculture, ecology, plant sciences, and biology.

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«Юность» – советский, затем российский литературно-художественный иллюстрированный журнал для молодёжи. Выходит в Москве с 1955 года.

Серия: Журнал «Юность» 2019

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The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 – 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.

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This revised edition of A History of Old English Literature draws extensively on the latest scholarship to have evolved over the last decade. The text incorporates additional material throughout, including two new chapters on Anglo-Saxon manuscripts and incidental and marginal texts. This revised edition responds to the renewed historicism in medieval studies Provides wide-ranging coverage, including Anglo-Latin literature as well as non-canonical writings Includes new chapters on manuscripts and on marginal and incidental texts Incorporates expanded coverage of legal texts and scientific and scholastic texts, now treated in separate chapters Demonstrates that the field of Anglo-Saxon studies is uniquely placed to contribute to current literary debates

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The book features comparative perspectives on the field of chemical ecology, present and future, offered by scientists from a wide variety of disciplines. The scientists contributing to this book –biologists, ecologists, biochemists, chemists, biostatisticians – are interested in marine, freshwater and terrestrial ecosystems and work on life forms ranging from micro-organisms to mammals, including humans, living in areas from the tropics to polar regions. Here, they cross their analyses of the present state of chemical ecology and its perspectives for the future. Those presented here include complex, multispecies communities and cover a wide range both of organisms and of the types of molecules that mediate the interactions between them. Up to now, no book has presented a solid scientific treatment of a wide range of examples. This book illustrates a diverse panel of the most advanced aspects of this rapidly expanding field.

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Presenting a wide array of information on chemical ligation – one of the more powerful tools for protein and peptide synthesis – this book helps readers understand key methodologies and applications that protein therapeutic synthesis, drug discovery, and molecular imaging. • Moves from fundamental to applied aspects, so that novice readers can follow the entire book and apply these reactions in the lab • Presents a wide array of information on chemical ligation reactions, otherwise scattered across the literature, into one source • Features comprehensive and multidisciplinary coverage that goes from basics to advanced topics • Helps researchers choose the right chemical ligation technique for their needs

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Автор: Группа авторов

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Автор: Группа авторов

Whereas other textbooks mix a clinical approach with large amounts of the basic science of gastroenterology, this book concentrates on providing practicing gastroenterologists with 100% clinically focused, evidence-based chapters on how to correctly diagnosis and treat all disorders of the digestive tract. Once again, the book is divided into 4 clear parts: Symptoms, Syndromes and Scenarios; Diseases of the Gut and Liver; Primer of Diagnostic Methods; and Primer of Treatments. An accompanying website contains more than 85 high-definition surgical videos of diagnostic and therapeutic endoscopic procedures, 300 MCQs written to mirror the American College of Gastroenterology postgraduate course exams, more than 35 management protocol charts for different diseases, and 850+ illustrations for use in scientific presentations.

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This collection of essays in Governing Global Land Deals provides new empirical and theoretical analyses of the relationships between global land grabs and processes of government and governance. Reframes debates on global land grabs by focusing on the relationship between large-scale land deals and processes of governance Offers new theoretical insights into the different forms and effects of global land acquisitions Illuminates both the micro-processes of transaction and expropriation, as well as the broader structural forces at play in global land deals Provides new empirical data on the different actors involved in contemporary land deals occurring across the globe and focuses on the specific institutional, political, and economic contexts in which they are acting

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Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.

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In Volume XV in the series «Advances in Electrochemical Science and Engineering» various leading experts from the field of electrochemical engineering share their insights into how different experimental and computational methods are used in transferring molecular-scale discoveries into processes and products. Throughout, the focus is on the engineering problem and method of solution, rather than on the specific application, such that scientists from different backgrounds will benefit from the flow of ideas between the various subdisciplines. A must-read for anyone developing engineering tools for the next-generation design and control of electrochemical process technologies, including chemical, mechanical and electrical engineers, as well as chemists, physicists, biochemists and materials scientists.

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The thoroughly revised Women in Culture 2/e explores the intersections of gender, race, sexuality, gender identity, and spirituality from the perspectives of diverse global locations. Its strong humanities content, including illustrations and creative writing, uniquely embraces the creative aspects of the field. Each of the ten thematic chapters lead to creative readings, introducing a more Readings throughout the text encourage intersectional thinking amongst students humanistic angle than is typical of textbooks in the field This textbook is queer inclusive and allows students to engage with postcolonial/decolonial thinking, spirituality, and reproductive/environmental justice A detailed timeline of feminist history, criticism and theory is provided, and the glossary encourages the development of critical vocabulary A variety of illustrations supplement the written materials, and an accompanying website offers instructors pedagogical resources

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Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug's discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the book's nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: – Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references – Contains information and insight that is new and often not even available from the primary literature  – Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market  – Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.

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The first book to provdie a comprehensive look at bioenergetics, the energy flow in living systems, by studying ion exchange and electron transfer processes in biological membranes and artificial bio-films, and how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells. The book: Discusses the ion fluxes and electron transfer processes in biological membranes and artificial bio-films Provides an in-depth description of the processes at the interface between the membrane/film and substrate electrode Is the first of its kind to provide a comprehensive look at how these processes are understood in biology of living cells Addresses how these processes contribute to developing modern biosensor and ion-sensor technology, as well as biofuel cells

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This useful, one-stop resource for understanding the most important issues in materials challenges in alternative and renewable energy. The logically organized and carefully selected articles give insight into materials challenges in alternative renewable energy and incorporate the latest developments related to materials challenges in alternative renewable energy, including hydrogen, batteries and energy storage materials, hydropower, and biomass.

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Discover the science of biocomputing with this comprehensive and forward-looking new resource DNA- and RNA-Based Computing Systems delivers an authoritative overview of DNA- and RNA-based biocomputing systems that touches on cutting-edge advancements in computer science, biotechnology, nanotechnology, and materials science. Accomplished researcher, academic, and author Evgeny Katz offers readers an examination of the intersection of computational, chemical, materials, and engineering aspects of biomolecular information processing. A perfect companion to the recently published Enzyme-Based Computing by the same editor, the book is an authoritative reference for those who hope to better understand DNA- and RNA-based logic gates, multi-component logic networks, combinatorial calculators, and related computational systems that have recently been developed for use in biocomputing devices. DNA- and RNA-Based Computing Systems summarizes the latest research efforts in this rapidly evolving field and points to possible future research foci. Along with an examination of potential applications in biosensing and bioactuation, particularly in the field of biomedicine, the book also includes topics like: A thorough introduction to the fields of DNA and RNA computing, including DNA/enzyme circuits A description of DNA logic gates, switches and circuits, and how to program them An introduction to photonic logic using DNA and RNA The development and applications of DNA computing for use in databases and robotics Perfect for biochemists, biotechnologists, materials scientists, and bioengineers, DNA- and RNA-Based Computing Systems also belongs on the bookshelves of computer technologists and electrical engineers who seek to improve their understanding of biomolecular information processing. Senior undergraduate students and graduate students in biochemistry, materials science, and computer science will also benefit from this book.

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Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

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The analysis of plants, insects, soil and other particulates from scenes of crime can be vital in proving or excluding contact between a suspect and a scene, targeting search areas, and establishing a time and place of death. Forensic Ecology: A Practitioner’s Guide provides a complete handbook covering all aspects of forensic ecology. Bringing together the forensic applications of anthropology, archaeology, entomology, palynology and sedimentology in one volume, this book provides an essential resource for practitioners in the field of forensic science, whether crime scene investigators, forensic science students or academics involved in the recovery and analysis of evidence from crime scenes. Forensic Ecology: A Practitioner’s Guide includes information not only on the search, location, recovery and analysis of evidence, but includes sampling strategies for diatom analysis, pollen and soils samples and entomology and provides guides for good practice. Each chapter provides background information on each discipline and is structured according to pre-scene attendance (what questions should the scientist ask when receiving a call? What sort of preparation is required?), scene attendance (including protocols at the scene, sampling strategies, recording), scientific examination of analysis of the evidence up to the stages and guidelines for witness statement and presenting evidence in court. The book is written by specialists in all fields with a wealth of experience who are current forensic practitioners around the world. It provides an essential and accessible resource for students, academics, forensic practitioners and police officers everywhere.

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Автор: Группа авторов

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Автор: Группа авторов

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Автор: Е. А. Василенко

В статье проанализированы существующие открытые объектно-ориентированные системы, которые можно использовать в качестве среды для разработки и размещения электронных информационно-образовательных ресурсов, в том числе и для дистанционного обучения. Обоснована необходимость использования модульной объектно-ориентированной среды Moodle для создания учебного портала РХТУ им. Д. И. Менделеева (http://moodle.muctr.ru). В работе рассмотрены возможности Moodle для разработки электронных информационно-образовательных ресурсов и описаны разработанные обучающие материалы по дисциплинам «Информационные технологи в химии» и «Защита интеллектуальной собственности» в соответствии с учебным планом подготовки студентов химиков-технологов.

Серия: Прикладная информатика. Научные статьи

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Автор: Е. А. Кирсанов

Неньютоновское поведение структурированных систем проявляется в изменении вязкости при изменении скорости сдвигового течения. Структурная реологическая модель объясняет явление неньютоновского течения в суспензиях, эмульсиях, мицеллярных растворах, растворах и расплавах полимеров, а также в жидких кристаллах. Полученные реологические уравнения описывают вязкость и силы упругости при стационарном течении, вязкие и упругие характеристики при сдвиговых колебаниях. Структурный подход является альтернативой классической теории вязкоупругости и связывает изменение вязкости с изменением структуры вещества. Коэффициенты полученных уравнений прямо связаны со структурой и физико-химическими свойствами структурированных систем. Рассмотрены практически важные системы: полимеры и композитные материалы, нефть и буровые растворы, тиксотропные красители и кровь. Книга может быть полезной для ученых и специалистов в области физикохимии дисперсных систем, коллоидной химии и физикохимии полимеров, медицины.

Серия: Мир химии

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Автор: Е. В. Малышева

Сборник задач представляет собой комплекс заданий, позволяющий студенту оптимальным образом организовать процесс подготовки к практическому занятию, содержит план практических занятий, краткий теоретический материал, задачи и тестовые задания для решения на практических занятиях, а также списки вопросов для размышления.

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Автор: З. Х. Сергеева

В работе рассматриваются сложные процессы развития и функционирования нефтяной отрасли. Автор выделил и проанализировал ключевые этапы в истории становления мировой нефтяной отрасли. В книге также показано, что в XX в. развитие общества обусловлено беспрецедентным ростом энергопотребления в целом, а также углеводородов в частности.

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Автор: С. М. Дробышевский

Работа посвящена проверке стандартных гипотез относительно поведения показателей, характеризующих временную структуру процентных ставок на российском рынке ГКО-ОФЗ, выявлению и анализу произошедших в период между кризисами (1998–2008 гг.) изменений во временной структуре процентных ставок, их реакции на трансформацию макроэкономических показателей в 1999–2008 гг.

Серия: Научные труды. Институт экономической политики имени Е. Т. Гайдара

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Автор: Alexandra Bolena

Sie wollen mit Ihren Geldgesch?ften die Welt ein bisschen besser machen? Ihr Erspartes in Unternehmen mit einer nachhaltigen Gesch?ftsidee investieren, die umweltfreundlich und fair wirtschaften und vielleicht sogar noch soziale Projekte unterst?tzen? Dieses Buch gibt Ihnen Tipps f?r die Auswahl von nachhaltigen Aktien, Anleihen, ESG-konformen Fonds und ETFs. Dar?ber hinaus gibt es f?r Sie als nachhaltig orientierten Anleger aber noch eine Vielzahl anderer innovativer M?glichkeiten, Ihr Geld «gut» anzulegen: Lesen Sie alles ?ber Green und Social Bonds, Investments in nachhaltige Sachwerte, Mikrofinanz oder Crowdinvesting und warum eines dieser Themen sicher auch zu Ihren Vorstellungen passt. Erfahren Sie, wie Sie echte nachhaltige Angebote von solchen, die «Green-washing» betreiben, unterscheiden, warum die SDGs eine gute Messlatte sind, was G?tesiegel aussagen und last but not least warum auch Ihre Hausbank einen Beitrag leisten kann und wie Sie dieser in Sachen Nachhaltigkeit auf den Zahn f?hlen k?nnen.

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Автор: Andrea Bellelli

Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experiments Applies historical and physical insight to provide a clear understanding of ligand binding Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.

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Автор: Andrew Rolle

The eighth edition of California: A History covers the entire scope of the history of the Golden State, from before first contact with Europeans through the present; an accessible and compelling narrative that comprises the stories of the many diverse peoples who have called, and currently do call, California home. Explores the latest developments relating to California’s immigration, energy, environment, and transportation concerns Features concise chapters and a narrative approach along with numerous maps, photographs, and new graphic features to facilitate student comprehension Offers illuminating insights into the significant events and people that shaped the lengthy and complex history of a state that has become synonymous with the American dream Includes discussion of recent – and uniquely Californian – social trends connecting Hollywood, social media, and Silicon Valley – and most recently «Silicon Beach»

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Автор: Anthony K. Campbell

The definitive text on the key component for cell functions—intracellular calcium This comprehensive book reveals the evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells. It shows how the components required for calcium signaling are named and classified; covers the technology that has been developed to study intracellular calcium; describes how calcium is regulated inside cells and how it works to trigger an event; explains the role of intracellular calcium in disease, cell injury, and cell death; reveals how many drugs work through the calcium signaling system; and demonstrates how intracellular calcium is involved in the action of many natural toxins. The book also illustrates how the intracellular calcium signaling system has evolved over millions of years, showing why it was crucial to the origin of life. Additionally, the book promotes the importance of the molecular variation upon which the intracellular calcium signalling system depends. Featuring more than 100 figures (including detailed chemical structures as well as pictures of key pioneers in the field), a bibliography of some 1000 references, and a detailed subject index, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond. Emphasizes two key scientific principles—the first to show how intracellular Ca2+ acts as a switch, to activate a wide range of cellular events, and the second demonstrating how an analogue mechanism can be superimposed on such a process Written by an internationally recognized expert in the field Filled with images and references to facilitate learning Fundamentals of Intracellular Calcium is an all-important text for post-graduate students and researchers working in biomedicine and biochemistry. It is also essential for undergraduate lecturers and their students in physiology, medicine, pharmacy, and the biosciences.

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Автор: Antonio A. Munjiza

Mechanics of Discontinua is the first book to comprehensively tackle both the theory ofthis rapidly developing topic and the applications that span a broad field of scientific and engineering disciplines, from traditional engineering to physics of particulates, nano-technology and micro-flows. Authored by a leading researcher who has been at the cutting edge of discontinua simulation developments over the last 15 years, the book is organized into four parts: introductory knowledge, solvers, methods and applications. In the first chapter a short revision of Continuum Mechanics together with tensorial calculus is introduced. Also, a short introduction to the finite element method is given. The second part of the book introduces key aspects of the subject. These include a diverse field of applications, together with fundamental theoretical and algorithmic aspects common to all methods of Mechanics of Discontinua. The third part of the book proceeds with the most important computational and simulation methods including Discrete Element Methods, the Combined Finite-Discrete Element Method, Molecular Dynamics Methods, Fracture and Fragmentation solvers and Fluid Coupling. After these the reader is introduced to applications stretching from traditional engineering and industry (such as mining, oil industry, powders) to nanotechnology, medical and science.

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Автор: Atul Jain

This book covers several aspects of the fatigue behavior of textile and short fiber reinforced composites. The first part is dedicated to 2D and 3D reinforced textile composites and includes a systematic description of the damage evolution for quasi-static and tensile-tensile fatigue loadings. Acoustic emissions and digital image correlation are considered in order to detect the damage modes’ initiation and development. The acoustic emission thresholds of the quasi-static loading are connected to the “fatigue limit” of the materials with distinctions for glass and carbon reinforcements. The second part is devoted to the fatigue behavior of injection molded short fiber reinforced composites. Experimental evidence highlights the dependence of their fatigue response on various factors: fiber and matrix materials, fiber distribution, environmental and loading conditions are described. A hybrid (experimental/simulations) multi-scale method is presented, which drastically reduces the amount of experimental data necessary for reliable fatigue life predictions.

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Автор: B. Kim Barnes

Change minds, guide opinions, and shape emotions with the power of effective influence Exercising Influence is your guide to accomplishing more with less effort. Demystifying the process of influencing others, this book shows you how to develop effective influence behaviors, plan an influence approach, set goals, resolve problems, and build better relationships. Revised and expanded to provide more actionable advice across industries and sectors, this third edition has updated examples and resources and features all-new chapters on influencing through social media, influencing your team, and applying research findings of neuroscience, and behavioral economics.. You'll create work, family, and community relationships that are more mutually rewarding as you apply a practical, real-world model for developing this seldom-taught skill. Influence is a skillset that everyone needs, yet the necessary techniques and fundamentals are rarely made explicit and shared. This book is a vital resource for anyone who wants to achieve better outcomes at work, at home, or in the world at large, helping you make important things happen and create relationships that matter. Develop a strategic and tactical approach to influence that gets results. Resolve problems and conflicts, and build more balanced relationships. Do more with less, increase your impact on others, and take greater charge of your life. Take advantage of new methodologies that build your skills as an influencer. Influence is a timeless topic for business leaders and others in positions of power, but the world has evolved to the point where everyone needs these skills. No matter your job, role, rank, or function, if you want to get things done you need to know how to influence up, down, across, and outside the organization. With improved skills, you can steer opinions, impact decisions, and sway the undecided. If you're ready to see what you're capable of, Exercising Influence will show you how to take charge of your professional and personal life in a powerful, ethical, and productive way. http://www.wiley.com/WileyCDA/WileyTitle/productCd-1119071585.html

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Автор: Ceri Davies

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Автор: Charles C. Hong

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies. In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. This volume provides an essential overview of this emerging technology for researchers in academic, industrial and clinical environments working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering. It is appropriate for training students and newcomers to the field, benefitting readers in broadening their knowledge and giving them insights to regenerative chemical biology, as well as encouraging readers to implement the key points in their own fields of study to develop new technologies.

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Автор: Charles E. Schaefer

An integrative approach to play therapy blending various therapeutic treatment models and techniques Reflecting the transition in the field of play therapy from a «one size fits all» approach to a more eclectic framework that integrates more than one perspective, Integrative Play Therapy explores methods for blending the best theories and treatment techniques to resolve the most common psychological disorders of childhood. Edited by internationally renowned leaders in the field, this book is the first of its kind to look at the use of a multi-theoretical framework as a foundation for practice. With discussion of integrative play treatment of children presenting a wide variety of problems and disorders—including aggression issues, the effects of trauma, ADHD, anxiety, obsessive-compulsive disorders, social skills deficits, medical issues such as HIV/AIDS, and more—the book provides guidance on: Play and group therapy approaches Child-directed play therapy with behavior management training for parents Therapist-led and child-led play therapies Cognitive-behavioral therapy with therapeutic storytelling and play therapy Family therapy and play therapy Bibliotherapy within play therapy An essential resource for all mental health professionals looking to incorporate play therapy into treatment, Integrative Play Therapy reveals unique flexibility in integrating theory and techniques, allowing practitioners to offer their clients the best treatment for specific presenting problems.

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Автор: Daniel Lednicer

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

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Автор: E. Mark Haacke

New edition explores contemporary MRI principles and practices Thoroughly revised, updated and expanded, the second edition of Magnetic Resonance Imaging: Physical Principles and Sequence Design remains the preeminent text in its field. Using consistent nomenclature and mathematical notations throughout all the chapters, this new edition carefully explains the physical principles of magnetic resonance imaging design and implementation. In addition, detailed figures and MR images enable readers to better grasp core concepts, methods, and applications. Magnetic Resonance Imaging, Second Edition begins with an introduction to fundamental principles, with coverage of magnetization, relaxation, quantum mechanics, signal detection and acquisition, Fourier imaging, image reconstruction, contrast, signal, and noise. The second part of the text explores MRI methods and applications, including fast imaging, water-fat separation, steady state gradient echo imaging, echo planar imaging, diffusion-weighted imaging, and induced magnetism. Lastly, the text discusses important hardware issues and parallel imaging. Readers familiar with the first edition will find much new material, including: New chapter dedicated to parallel imaging New sections examining off-resonance excitation principles, contrast optimization in fast steady-state incoherent imaging, and efficient lower-dimension analogues for discrete Fourier transforms in echo planar imaging applications Enhanced sections pertaining to Fourier transforms, filter effects on image resolution, and Bloch equation solutions when both rf pulse and slice select gradient fields are present Valuable improvements throughout with respect to equations, formulas, and text New and updated problems to test further the readers' grasp of core concepts Three appendices at the end of the text offer review material for basic electromagnetism and statistics as well as a list of acquisition parameters for the images in the book. Acclaimed by both students and instructors, the second edition of Magnetic Resonance Imaging offers the most comprehensive and approachable introduction to the physics and the applications of magnetic resonance imaging.

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Автор: Evgeny Katz

This systematic and comprehensive overview of enzyme-based biocomputing is an excellent resource for scientists and engineers working on the design, study and applications of enzyme-logic systems.

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Автор: Gail Cardew

Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.

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Автор: George Ritzer

An accessible and comprehensive introduction to key concepts in globalization written by leading authors in the field  In the comprehensively revised Third Edition of  Globalization: A Basic Text , distinguished researchers and authors George Ritzer and Paul Dean deliver an up-to-date introduction to major trends and topics related to the study of globalization. The book includes accessible and rigorous material on the key theories and major topics in globalization, as well as modern developments like the rise of populism and far-right political groups, Brexit, migration and backlash to it, trade negotiations, social media and the spread of misinformation, climate change, social justice issues, and COVID-19.  The new edition includes a greater focus on the structures of inequality that encourage or discourage global flows. Additionally, new examples and sources from Central and South America, Africa, and Asia are used to illustrate key concepts, and round out the international coverage of book. Throughout, the authors use clear and helpful metaphors including solids, liquids, gases, and flows to introduce and explain the complex nature of globalization in an engaging and understandable way.  Readers will also benefit from the inclusion of:  A thorough introduction to globalization and related processes, including imperialism, colonialism, development, and westernization An exploration of neoliberalism, including its roots, principles, criticisms, and Neo-Marxist alternatives A practical discussion of global political structures and processes, as well as global economic flows of production and consumption A concise treatment of negative global flows and processes, including dangerous imports, diseases, crime, terrorism, and war Analysis of the changing nature of globalization and de-globalization, and the social movements and technological developments driving these changes More images, charts, and graphs to help illustrate and highlight the concepts contained in the book Perfect for advanced undergraduates studying globalization across sociology, political science, geography, anthropology, and economics,  Globalization: A Basic Text, Third Edition  will also be essential reading for students taking courses in culture, economy and inequality, and migration taught from a global perspective.

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Автор: Gerhard Krauss

Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere. Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on «the Krauss» to find their way through the bewildering complexity of biological signaling pathways.

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Автор: Gordon G. Hammes

This book provides an introduction to physical chemistry that is directed toward applications to the biological sciences. Advanced mathematics is not required. This book can be used for either a one semester or two semester course, and as a reference volume by students and faculty in the biological sciences.

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Автор: Hans Bisswanger

Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.

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Автор: Hassan Radoine

Architecture in Context: Designing in the Middle East provides a foundation for understanding the critical context of architecture and design in this region. It does this by: presenting a practical overview of architectural know-how in the Middle East, and its potential for cultivating a sense of place introducing local architectural vocabularies and styles, and how they can still be reactivated in contemporary design exploring the cultural and contextual meaning of forms as references that may influence contemporary architecture discussing important discourses and trends in architecture that allow a rethinking of the current global/local dichotomy. Highly illustrated, the book covers architecture and design in North Africa, the Levant, the Gulf, and Turkey, Iran and Iraq.

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Автор: Ignac Capek

There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA’s chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.

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