физическая химия (страница 2)

Автор: Группа авторов

Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.

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Автор: E. Mark Haacke

New edition explores contemporary MRI principles and practices Thoroughly revised, updated and expanded, the second edition of Magnetic Resonance Imaging: Physical Principles and Sequence Design remains the preeminent text in its field. Using consistent nomenclature and mathematical notations throughout all the chapters, this new edition carefully explains the physical principles of magnetic resonance imaging design and implementation. In addition, detailed figures and MR images enable readers to better grasp core concepts, methods, and applications. Magnetic Resonance Imaging, Second Edition begins with an introduction to fundamental principles, with coverage of magnetization, relaxation, quantum mechanics, signal detection and acquisition, Fourier imaging, image reconstruction, contrast, signal, and noise. The second part of the text explores MRI methods and applications, including fast imaging, water-fat separation, steady state gradient echo imaging, echo planar imaging, diffusion-weighted imaging, and induced magnetism. Lastly, the text discusses important hardware issues and parallel imaging. Readers familiar with the first edition will find much new material, including: New chapter dedicated to parallel imaging New sections examining off-resonance excitation principles, contrast optimization in fast steady-state incoherent imaging, and efficient lower-dimension analogues for discrete Fourier transforms in echo planar imaging applications Enhanced sections pertaining to Fourier transforms, filter effects on image resolution, and Bloch equation solutions when both rf pulse and slice select gradient fields are present Valuable improvements throughout with respect to equations, formulas, and text New and updated problems to test further the readers' grasp of core concepts Three appendices at the end of the text offer review material for basic electromagnetism and statistics as well as a list of acquisition parameters for the images in the book. Acclaimed by both students and instructors, the second edition of Magnetic Resonance Imaging offers the most comprehensive and approachable introduction to the physics and the applications of magnetic resonance imaging.

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Автор: Группа авторов

This useful, one-stop resource for understanding the most important issues in materials challenges in alternative and renewable energy. The logically organized and carefully selected articles give insight into materials challenges in alternative renewable energy and incorporate the latest developments related to materials challenges in alternative renewable energy, including hydrogen, batteries and energy storage materials, hydropower, and biomass.

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Автор: Paul Louis George

Triangulations, and more precisely meshes, are at the heart of many problems relating to a wide variety of scientific disciplines, and in particular numerical simulations of all kinds of physical phenomena. In numerical simulations, the functional spaces of approximation used to search for solutions are defined from meshes, and in this sense these meshes play a fundamental role. This strong link between the meshes and functional spaces leads us to consider advanced simulation methods in which the meshes are adapted to the behaviors of the underlying physical phenomena. This book presents the basic elements of this meshing vision.

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Автор: James C. Dabrowiak

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

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Автор: Saura C. Sahu

During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. Divided into six parts, topics covered include: microRNA and toxicology – including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancer microRNAs and disease states microRNAs and stem cells microRNAs and genomics microRNAs and epigenomics microRNAs and biomarkers – including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitis microRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government.

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Автор: Группа авторов

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Автор: Alexandra Bolena

Sie wollen mit Ihren Geldgesch?ften die Welt ein bisschen besser machen? Ihr Erspartes in Unternehmen mit einer nachhaltigen Gesch?ftsidee investieren, die umweltfreundlich und fair wirtschaften und vielleicht sogar noch soziale Projekte unterst?tzen? Dieses Buch gibt Ihnen Tipps f?r die Auswahl von nachhaltigen Aktien, Anleihen, ESG-konformen Fonds und ETFs. Dar?ber hinaus gibt es f?r Sie als nachhaltig orientierten Anleger aber noch eine Vielzahl anderer innovativer M?glichkeiten, Ihr Geld «gut» anzulegen: Lesen Sie alles ?ber Green und Social Bonds, Investments in nachhaltige Sachwerte, Mikrofinanz oder Crowdinvesting und warum eines dieser Themen sicher auch zu Ihren Vorstellungen passt. Erfahren Sie, wie Sie echte nachhaltige Angebote von solchen, die «Green-washing» betreiben, unterscheiden, warum die SDGs eine gute Messlatte sind, was G?tesiegel aussagen und last but not least warum auch Ihre Hausbank einen Beitrag leisten kann und wie Sie dieser in Sachen Nachhaltigkeit auf den Zahn f?hlen k?nnen.

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Автор: Группа авторов

A unique discussion of mathematical methods with applications to quantum mechanics Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects presents various mathematical constructions influenced by quantum mechanics and emphasizes the spectral theory of non-adjoint operators. Featuring coverage of functional analysis and algebraic methods in contemporary quantum physics, the book discusses the recent emergence of unboundedness of metric operators, which is a serious issue in the study of parity-time-symmetric quantum mechanics. The book also answers mathematical questions that are currently the subject of rigorous analysis with potentially significant physical consequences. In addition to prompting a discussion on the role of mathematical methods in the contemporary development of quantum physics, the book features: Chapter contributions written by well-known mathematical physicists who clarify numerous misunderstandings and misnomers while shedding light on new approaches in this growing area An overview of recent inventions and advances in understanding functional analytic and algebraic methods for non-selfadjoint operators as well as the use of Krein space theory and perturbation theory Rigorous support of the progress in theoretical physics of non-Hermitian systems in addition to mathematically justified applications in various domains of physics such as nuclear and particle physics and condensed matter physics An ideal reference, Non-Selfadjoint Operators in Quantum Physics: Mathematical Aspects is useful for researchers, professionals, and academics in applied mathematics and theoretical and/or applied physics who would like to expand their knowledge of classical applications of quantum tools to address problems in their research. Also a useful resource for recent and related trends, the book is appropriate as a graduate-level and/or PhD-level text for courses on quantum mechanics and mathematical models in physics.

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Автор: Michael Braun

In mechanical engineering the trend towards increasingly flexible solutions is leading to changes in control systems. The growth of mechatronic systems and modular functional units is placing high demands on software and its design. In the coming years, automation technology will experience the same transition that has already taken place in the PC world: a transition to more advanced and reproducible software design, simpler modification, and increasing modularity. This can only be achieved through object-oriented programming. This book is aimed at those who want to familiarize themselves with this development in automation technology. Whether mechanical engineers, technicians, or experienced automation engineers, it can help readers to understand and use object-oriented programming. From version 4.5, SIMOTION provides the option to use OOP in accordance with IEC 61131-3 ED3, the standard for programmable logic controllers. The book supports this way of thinking and programming and offers examples of various object-oriented techniques and their mechanisms. The examples are designed as a step-by-step process that produces a finished, ready-to-use machine module. Contents: Developments in the field of control engineering – General principles of object-oriented programming – Function blocks, methods, classes, interfaces – Modular software concepts – Object-oriented design, reusable and easy-to-maintain software, organizational and legal aspects, software tests – I/O references, namespaces, general references – Classes in SIMOTION, instantiation of classes and function blocks, compatible and efficient software – Introduction to SIMOTION and SIMOTION SCOUT.

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Автор: Richard J. D. Tilley

Uniquely describes both the crystallography and properties of perovskite related materials. Practical applications in solar cells, microelectronics and telecommunications Interdisciplinary topic drawing on materials science, chemistry, physics, and geology Contains problems and answers to enhance knowledge retention

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Автор: Pascal Granger

This comprehensive handbook and ready reference details all the main achievements in the field of perovskite-based and related mixed-oxide materials. The authors discuss, in an unbiased manner, the potentials as well as the challenges related to their use, thus offering new perspectives for research and development on both an academic and industrial level. The first volume begins by summarizing the different synthesis routes from molten salts at high temperatures to colloidal crystal template methods, before going on to focus on the physical properties of the resulting materials and their related applications in the fields of electronics, energy harvesting, and storage as well as electromechanics and superconductivity. The second volume is dedicated to the catalytic applications of perovskites and related mixed oxides, including, but not limited to total oxidation of hydrocarbons, dry reforming of methane and denitrogenation. The concluding section deals with the development of chemical reactors and novel perovskite-based applications, such as fuel cells and high-performance ceramic membranes. Throughout, the contributions clearly point out the intimate links between structure, properties and applications of these materials, making this an invaluable tool for materials scientists and for catalytic and physical chemists.

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Автор: Gordon G. Hammes

This book provides an introduction to physical chemistry that is directed toward applications to the biological sciences. Advanced mathematics is not required. This book can be used for either a one semester or two semester course, and as a reference volume by students and faculty in the biological sciences.

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Автор: Группа авторов

A fully revised review of the latest research in molecular basis of plant abiotic stress response and adaptation Abiotic stressors are non-living environmental stressors that can have a negative impact on a plants ability to grow and thrive in a given environment. Stressors can range from temperature stress (both extreme heat and extreme cold) water stress, aridity, salinity among others. This book explores the full gamut of plant abiotic stressors and plants molecular responses and adaptations to adverse environmental conditions. The new edition of Plant Abiotic Stress provides up-to-date coverage of the latest research advances in plant abiotic stress adaptation, with special emphasis on the associated and integrative aspects of physiology, signaling, and molecular-genetics. Since the last edition, major advances in whole genome analysis have revealed previously unknown linkages between genes, genomes, and phenotypes, and new biological and –omics approaches have elucidated previously unknown cellular mechanisms underlying stress tolerance. Chapters are organized by topic, but highlight processes that are integrative among diverse stress responses. As with the first edition, Plant Abiotic Stress will have broad appeal to scientists in fields of applied agriculture, ecology, plant sciences, and biology.

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Автор: Vladimir Uversky

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging. Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation process Cellular mechanisms for managing oxidized proteins Role of protein oxidation in aging Influence of genetic and environmental factors on protein oxidation Measuring protein oxidation in the aging process Protein oxidation in age-related diseases References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

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Автор: Paul Wicker

Rapid Perioperative Care is an essential text for students and practitioners requiring up-to-date fundamental information on the perioperative environment. Covering a wide range of subjects related to perioperative practice and care, each chapter is concise and focused to guide the reader to find information quickly and effectively. This book uses a structured approach to perioperative care, starting with an introduction to the perioperative environment, anaesthetics, surgery and recovery, followed by postoperative problems and finally the roles of the Surgical Care Practitioner (SCP). Covering all the key topics in the perioperative environment, this concise and easy-to-read title is the perfect quick-reference book for students and theatre practitioners to support them in their work in clinical practice, and enable them to deliver the best possible care.

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Автор: Andrea Bellelli

Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experiments Applies historical and physical insight to provide a clear understanding of ligand binding Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.

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Автор: Steven M. Rice

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Автор: Mark Karlen

Conquer the complexity of interior design with a logical, methodical approach Space Planning Basics is a definitive introduction and principle resource for thousands of designers. With step-by-step methodology based on the author’s several decades of design experience, this authoritative guide has become the de facto reference for an entire generation of designers. This updated fourth edition includes digitized drawings, diagrams, and matrices throughout, and newly added supplemental photographs. The text has been revised to reflect the latest developments in sustainable and universal design, including coverage of daylighting, benchmarking, LEED system standards, and green code issues. The companion website provides AutoCAD files, intrustor videos and matrices to give you a deeper real-world understanding of the design process. This book is perfect preparation for the NCIDQ exam. Proper space planning goes way beyond sketching a preliminary floor plan. Successful implementation includes a balanced integration of code compliance, system support, and adherence to the client’s functional needs. Sustainability adds a new, important layer of complexity. This book shows you how to approach space planning in a way that ensures all considerations are met, and nothing gets lost in the process. Adopt an organized and comprehensive planning methodology Work effectively with dimensionally challenging spaces Consider building systems, codes, lighting, acoustics, and more Develop advanced skills and conquer new challenges Space planning encompasses many components and processes, making a comprehensive reference necessary for mastery of the field. Space Planning Basics is a thorough, methodical resource that gets you started on the right track, with plenty of room for creativity.

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Автор: Sarah Werner

A comprehensive resource to understanding the hand-press printing of early books Studying Early Printed Books, 1450 – 1800 offers a guide to the fascinating process of how books were printed in the first centuries of the press and shows how the mechanics of making books shapes how we read and understand them. The author offers an insightful overview of how books were made in the hand-press period and then includes an in-depth review of the specific aspects of the printing process. She addresses questions such as: How was paper made? What were different book formats? How did the press work? In addition, the text is filled with illustrative examples that demonstrate how understanding the early processes can be helpful to today’s researchers. Studying Early Printed Books shows the connections between the material form of a book (what it looks like and how it was made), how a book conveys its meaning and how it is used by readers. The author helps readers navigate books by explaining how to tell which parts of a book are the result of early printing practices and which are a result of later changes. The text also offers guidance on: how to approach a book; how to read a catalog record; the difference between using digital facsimiles and books in-hand. This important guide: Reveals how books were made with the advent of the printing press and how they are understood today Offers information on how to use digital reproductions of early printed books as well as how to work in a rare books library Contains a useful glossary and a detailed list of recommended readings Includes a companion website for further research Written for students of book history, materiality of text and history of information, Studying Early Printed Books explores the many aspects of the early printing process of books and explains how their form is understood today.

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Автор: Группа авторов

Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug's discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the book's nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: – Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references – Contains information and insight that is new and often not even available from the primary literature  – Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market  – Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.

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Автор: Gail Cardew

Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.

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Автор: Ceri Davies

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Автор: Группа авторов

Whereas other textbooks mix a clinical approach with large amounts of the basic science of gastroenterology, this book concentrates on providing practicing gastroenterologists with 100% clinically focused, evidence-based chapters on how to correctly diagnosis and treat all disorders of the digestive tract. Once again, the book is divided into 4 clear parts: Symptoms, Syndromes and Scenarios; Diseases of the Gut and Liver; Primer of Diagnostic Methods; and Primer of Treatments. An accompanying website contains more than 85 high-definition surgical videos of diagnostic and therapeutic endoscopic procedures, 300 MCQs written to mirror the American College of Gastroenterology postgraduate course exams, more than 35 management protocol charts for different diseases, and 850+ illustrations for use in scientific presentations.

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Автор: Joseph J. Provost

Written as a textbook with an online laboratory manual for students and adopting faculties, this work is intended for non-science majors / liberal studies science courses and will cover a range of scientific principles of food, cooking and the science of taste and smell. Chapters include: The Science of Food and Nutrition of Macromolecules; Science of Taste and Smell; Milk, Cream, and Ice Cream, Metabolism and Fermentation; Cheese, Yogurt, and Sour Cream; Browning; Fruits and Vegetables; Meat, Fish, and Eggs; Dough, Cakes, and Pastry; Chilies, Herbs, and Spices; Beer and Wine; and Chocolate, Candy and Other Treats. Each chapters begins with biological, chemical, and /or physical principles underlying food topics, and a discussion of what is happening at the molecular level. This unique approach is unique should be attractive to chemistry, biology or biochemistry departments looking for a new way to bring students into their classroom. There are no pre-requisites for the course and the work is appropriate for all college levels and majors.

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Автор: Jerome Piriou

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Автор: Liz Palika

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Автор: John C. Cavadini

The definitive compendium of Cavadini’s essays on Augustine Visioning Augustine offers readers an expertly selected collection of essays exploring the text and history of the theology of Saint Augustine. Prominent scholar and essayist, John Cavadini, offers modern audiences an innovative framework for understanding Augustine, integrating articles and essays on significant texts, historical and contemporary perspectives and insights into Augustine’s development as a theologian. Examining themes such as the transformation of the human will in De doctrina Christiana and Augustine’s critique of philosophy in City of God, Cavadini provides clear and accessible smaller-size essays that serve as entry points for those interested in Augustinian scholarship. The author’s meditations on Augustinian texts invite readers to re-evaluate their interpretations and learn about the subtle and sophisticated vocabulary of Augustine. An encounter with Augustine the Christian theologian, Cavadini contends, is not a narrowly focused parochial experience, but instead a challenge to enlarge our horizons. Written by one of the most prominent Augustinian scholars and essayists in the field Addresses ecumenical and cultural issues that weaken contemporary interest in Christian faith Offers modern readers historical context on Augustinian theology Provides a single-volume collection of Cavadini’s essays on Augustine written over the course of more than two decades Accessible prose and intellectual sensitivity to modern theological problemsmake Visioning Augustine an indispensable volume for graduate students, scholars and professionals in all areas of Christian theology.

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Автор: Группа авторов

The thoroughly revised Women in Culture 2/e explores the intersections of gender, race, sexuality, gender identity, and spirituality from the perspectives of diverse global locations. Its strong humanities content, including illustrations and creative writing, uniquely embraces the creative aspects of the field. Each of the ten thematic chapters lead to creative readings, introducing a more Readings throughout the text encourage intersectional thinking amongst students humanistic angle than is typical of textbooks in the field This textbook is queer inclusive and allows students to engage with postcolonial/decolonial thinking, spirituality, and reproductive/environmental justice A detailed timeline of feminist history, criticism and theory is provided, and the glossary encourages the development of critical vocabulary A variety of illustrations supplement the written materials, and an accompanying website offers instructors pedagogical resources

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