химия полимеров (страница 2)

Автор: Prof. Lars O. Nord

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Автор: Группа авторов

Carotenoids are an essential component of the human diet. Bioactive by nature, they are rich in antioxidants, promote vitamin A activity and lower the development of chronic illnesses. As such they are an area of growing interest to researchers and scientists who are working to design, develop and launch new functional food products, dietary supplements and other nutritional solutions. Carotenoids: Nutrition, Analysis and Technology is an up-to-date overview of the key areas of carotenoids in nutrition, therapy and technology. In the first section, the authors present a functional food perspective, outlining the therapeutic applications of the bioactive pigments. The second part is dedicated to the spectroscopic analysis of carotenoids, providing in-depth scientific methods and real research findings. In the final section, various technological applications of carotenoids are considered, including biotechnology and future prospects. Written by international experts in the field, this comprehensive book will be of interest to food scientists and researchers, nutritionists and health food companies. It will be of particular use to anyone involved in the spectroscopic analysis of carotenoids and other related bioactives.

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Автор: Группа авторов

Green, clean and renewable are the hottest keywords for catalysis and industry. This handbook and ready reference is the first to combine the fields of advanced experimentation and catalytic process development for biobased materials in industry. It describes the entire workflow from idea, approach, research, and process development, right up to commercialization. A large part of the book is devoted to the use of advanced technologies and methodologies like high throughput experimentation, as well as reactor and process design models, with a wide selection of real-life examples included at each stage. The contributions are from authors at leading companies and institutes, providing firsthand information and knowledge that is hard to find elsewhere. This work is aimed at decision makers, engineers and chemists in industry, chemists and engineers working with/on renewables, chemists in the field of catalysis, and chemical engineers.

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Автор: Volkan Cicek

A companion to the title Corrosion Chemistry, this volume covers both the theoretical aspects of cathodic protection and the practical applications of the technology, including the most cutting-edge processes and theories. Engineers and scientists across a wide range of disciplines and industries will find this the most up-to-date, comprehensive treatment of cathodic protection available. A superb reference and refresher on the chemistry and uses of the technology for engineers in the field, the book also provides a tremendous introduction to the science for newcomers to the field.

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Автор: Tanja Wuestenberg

Cellulose and its derivatives can be found in many forms in nature and is a valuable material for all manner of applications in industry. This book is authored by an expert with many years of experience as an application engineer at renowned cellulose processing companies in the food industry. All the conventional and latest knowledge available on cellulose and its derivatives is presented. The necessary details are elucidated from a theoretical and practical viewpoint, while retaining the focus on food applications. This book is an essential source of information and includes recommendations and instructions of a general nature to assist readers in the exploration of possible applications of cellulose and its derivatives, as well as providing food for thought for the generation of new ideas for product development. Topics include gelling and rheological properties, synergistic effects with other hydrocolloids, as well as nutritional and legal aspects. The resulting compilation covers all the information and advice needed for the successful development, implementation, and handling of cellulose-containing products.

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Автор: Jeffrey L. Buller

Initiate innovation and get things done with a guide to the process of academic change Change Leadership in Higher Education is a call to action, urging administrators in higher education to get proactive about change. The author applies positive and creative leadership principles to the issue of leading change in higher education, providing a much-needed blueprint for changing the way change happens, and how the system reacts. Readers will examine four different models of change and look at change itself through ten different analytical lenses to highlight the areas where the current approach could be beneficially altered. The book accounts for the nuances in higher education culture and environment, and helps administrators see that change is natural and valuable, and can be addressed in creative and innovative ways. The traditional model of education has been disrupted by MOOCs, faculty unions, online instruction, helicopter parents, and much more, leaving academic leaders accustomed to managing change. Leading change, however, is unfamiliar territory. This book is a guide to being proactive about change in a way that ensures a healthy future for the institution, complete with models and tools that help lead the way. Readers will: Learn to lead change instead of simply «managing» it Examine different models of change, and redefine existing approaches Discover a blueprint for changing the process of change Analyze academic change through different lenses to gain a wider perspective Leading change involves some challenges, but this useful guide is a strong conceptual and pragmatic resource for forecasting those challenges, and going in prepared. Administrators and faculty no longer satisfied with the status quo can look to Change Leadership in Higher Education for real, actionable guidance on getting change accomplished.

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Автор: Группа авторов

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Автор: Francis Rouessac

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Автор: Jeffrey J. Heys

Presents standard numerical approaches for solving common mathematical problems in engineering using Python. Covers the most common numerical calculations used by engineering students Covers Numerical Differentiation and Integration, Initial Value Problems, Boundary Value Problems, and Partial Differential Equations Focuses on open ended, real world problems that require students to write a short report/memo as part of the solution process Includes an electronic download of the Python codes presented in the book

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Автор: Группа авторов

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Автор: Группа авторов

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Автор: Jack Hipple

Outlines the concepts of chemical engineering so that non-chemical engineers can interface with and understand basic chemical engineering concepts Overviews the difference between laboratory and industrial scale practice of chemistry, consequences of mistakes, and approaches needed to scale a lab reaction process to an operating scale Covers basics of chemical reaction eningeering, mass, energy, and fluid energy balances, how economics are scaled, and the nature of various types of flow sheets and how they are developed vs. time of a project Details the basics of fluid flow and transport, how fluid flow is characterized and explains the difference between positive displacement and centrifugal pumps along with their limitations and safety aspects of these differences Reviews the importance and approaches to controlling chemical processes and the safety aspects of controlling chemical processes, Reviews the important chemical engineering design aspects of unit operations including distillation, absorption and stripping, adsorption, evaporation and crystallization, drying and solids handling, polymer manufacture, and the basics of tank and agitation system design

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Автор: Robin Smith

Written by a highly regarded author with industrial and academic experience, this new edition of an established bestselling book provides practical guidance for students, researchers, and those in chemical engineering. The book includes a new section on sustainable energy, with sections on carbon capture and sequestration, as a result of increasing environmental awareness; and a companion website that includes problems, worked solutions, and Excel spreadsheets to enable students to carry out complex calculations.

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Автор: Jacob A. Moulijn

With a focus on actual industrial processes, e.g. the production of light alkenes, synthesis gas, fine chemicals, polyethene, it encourages the reader to think “out of the box” and invent and develop novel unit operations and processes. Reflecting today’s emphasis on sustainability, this edition contains new coverage of biomass as an alternative to fossil fuels, and process intensification. The second edition includes: New chapters on Process Intensification and Processes for the Conversion of Biomass Updated and expanded chapters throughout with 35% new material overall Text boxes containing case studies and examples from various different industries, e.g. synthesis loop designs, Sasol I Plant, Kaminsky catalysts, production of Ibuprofen, click chemistry, ammonia synthesis, fluid catalytic cracking Questions throughout to stimulate debate and keep students awake! Richly illustrated chapters with improved figures and flow diagrams Chemical Process Technology, Second Edition is a comprehensive introduction, linking the fundamental theory and concepts to the applied nature of the subject. It will be invaluable to students of chemical engineering, biotechnology and industrial chemistry, as well as practising chemical engineers. From reviews of the first edition: “The authors have blended process technology, chemistry and thermodynamics in an elegant manner… Overall this is a welcome addition to books on chemical technology.” – The Chemist “Impressively wide-ranging and comprehensive… an excellent textbook for students, with a combination of fundamental knowledge and technology.” – Chemistry in Britain (now Chemistry World)

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Автор: Juan A. Conesa

A guide to the technical and calculation problems of chemical reactor analysis, scale-up, catalytic and biochemical reactor design Chemical Reactor Design offers a guide to the myriad aspects of reactor design including the use of numerical methods for solving engineering problems. The author – a noted expert on the topic – explores the use of transfer functions to study residence time distributions, convolution and deconvolution curves for reactor characterization, forced-unsteady-state-operation, scale-up of chemical reactors, industrial catalysis, design of multiphasic reactors, biochemical reactors design, as well as the design of multiphase gas-liquid-solid reactors. Chemical Reactor Design contains several examples of calculations and it gives special emphasis on the numerical solutions of differential equations by using the finite differences approximation, which offers the background information for understanding other more complex methods. The book is designed for the chemical engineering academic community and includes case studies on mathematical modeling by using of MatLab software. This important book: – Offers an up-to-date insight into the most important developments in the field of chemical, catalytic, and biochemical reactor engineering – Contains new aspects such as the use of numerical methods for solving engineering problems, transfer functions to study residence time distributions, and more – Includes illustrative case studies on MatLab approach, with emphasis on numerical solution of differential equations using the finite differences approximation Written for chemical engineers, mechanical engineers, chemists in industry, complex chemists, bioengineers, and process engineers, Chemical Reactor Design addresses the technical and calculation problems of chemical reactor analysis, scale-up, as well as catalytic and biochemical reactor design.

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Автор: Peter Fisk

This book is an essential guide and support to understanding of the science and policy, procedure and practice that underpins the REACH risk assessments required for the use and placing on the market of chemicals in the European Union. A clear understanding of information provision and how this affects the assessment of chemical safety is fundamentally important to the success of policy on chemicals and ultimately to the sustainability of the chemicals industry. Within the book, the scientific processes that underpin the policy are explained in a practical way. Importantly, it includes coverage of techniques to help solve the problems of using potentially risky and hazardous chemicals through the use of less hazardous alternatives and ‘green chemistry’, and also the analysis of the risks of the use of the most hazardous substances against the social and economic benefits of use. Chemical Risk Assessment: A Manual for REACH covers the following main themes: i) Assessment of chemical risk; ii) Risk management; iii) Hazard reduction, substitution and green chemistry; iv) Risk versus benefit – socio-economic analysis. The book acts as a practical guide and overview to chemicals risk assessment and risk management (in the EU context), as well as a support text for planning for the challenges of the future, which will see ever-increasing pressure to withdraw hazardous substances from the EU (and global) market, balanced against opportunities for innovation in the development of less hazardous chemicals.

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Автор: Andreas Jess

This textbook provides an integral and integrated treatment of industrial-relevant problems for students of both chemistry and chemical engineering. As such, this work combines the four disciplines of chemical technology – chemistry, thermal and mechanical unit operations, chemical reaction engineering and general chemical technology – and is organized into two main parts. The first covers the fundamentals, as well as the analysis and design of industrial processes, while the second section presents 20 concrete processes, exemplifying the inherent applied nature of chemical technology. These are selected so that they all differ with respect to at least one important aspect, such as the type and design of the reactor, the chemistry involved or the separation process used. As a result, readers will recapitulate, deepen and exercise the chemical and engineering principles and their interplay, as well as being able to apply them to industrial practice. Instructive figures, rules of thumb for swift but reliable estimating of parameters, data of chemical media, and examples utilizing data from industrial processes facilitate and enhance the study process. A small general survey of selected modern trends, such as multifunctional and micro reactors, or new solvents for homogeneous catalysis, such as ionic liquids, point out to the reader that this is not a concluded discipline, but a developing field with many challenges waiting to be solved.

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Автор: Andreas Jess

A fully updated edition of a popular textbook covering the four disciplines of chemical technology?featuring new developments in the field Clear and thorough throughout, this textbook covers the major sub-disciplines of modern chemical technology?chemistry, thermal and mechanical unit operations, chemical reaction engineering, and general chemical technology?alongside raw materials, energy sources and detailed descriptions of 24 important industrial processes and products. It brings information on energy and raw material consumption and production data of chemicals up to date and offers not just improved and extended chapters, but completely new ones as well. This new edition of Chemical Technology: From Principles to Products features a new chapter illustrating the global economic map and its development from the 15th century until today, and another on energy consumption in human history. Chemical key technologies for a future sustainable energy system such as power-to-X and hydrogen storage are now also examined. Chapters on inorganic products, material reserves, and water consumption and resources have been extended, while another presents environmental aspects of plastic pollution and handling of plastic waste. The book also adds four important processes to its pages: production of titanium dioxide, silicon, production and chemical recycling of polytetrafluoroethylene, and fermentative synthesis of amino acids. -Provides comprehensive coverage of chemical technology?from the fundamentals to 24 of the most important processes -Intertwines the four disciplines of chemical technology: chemistry, thermal and mechanical unit operations, chemical reaction engineering and general chemical technology -Fully updated with new content on: power-to-X and hydrogen storage; inorganic products, including metals, glass, and ceramics; water consumption and pollution; and additional industrial processes -Written by authors with extensive experience in teaching the topic and helping students understand the complex concepts Chemical Technology: From Principles to Products, Second Edition is an ideal textbook for advanced students of chemical technology and will appeal to anyone in chemical engineering.

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Автор: Robert J. Kee

A guide to the theoretical underpinnings and practical applications of chemically reacting flow Chemically Reacting Flow: Theory, Modeling, and Simulation, Second Edition combines fundamental concepts in fluid mechanics and physical chemistry while helping students and professionals to develop the analytical and simulation skills needed to solve real-world engineering problems. The authors clearly explain the theoretical and computational building blocks enabling readers to extend the approaches described to related or entirely new applications. New to this Second Edition are substantially revised and reorganized coverage of topics treated in the first edition. New material in the book includes two important areas of active research: reactive porous-media flows and electrochemical kinetics. These topics create bridges between traditional fluid-flow simulation approaches and transport within porous-media electrochemical systems. The first half of the book is devoted to multicomponent fluid-mechanical fundamentals. In the second half the authors provide the necessary fundamental background needed to couple reaction chemistry into complex reacting-flow models. Coverage of such topics is presented in self-contained chapters, allowing a great deal of flexibility in course curriculum design. • Features new chapters on reactive porous-media flow, electrochemistry, chemical thermodynamics, transport properties, and solving differential equations in MATLAB • Provides the theoretical underpinnings and practical applications of chemically reacting flow • Emphasizes fundamentals, allowing the analyst to understand fundamental theory underlying reacting-flow simulations • Helps readers to acquire greater facility in the derivation and solution of conservation equations in new or unusual circumstances • Reorganized to facilitate use as a class text and now including a solutions manual for academic adopters Computer simulation of reactive systems is highly efficient and cost-effective in the development, enhancement, and optimization of chemical processes. Chemically Reacting Flow: Theory, Modeling, and Simulation, Second Edition helps prepare graduate students in mechanical or chemical engineering, as well as research professionals in those fields take utmost advantage of that powerful capability.

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Автор: Johannes Karl Fink

Before the 1970s, most information concerning the conservation and restoration of paintings, wood, and archaeological artefacts were focused on the history of the artefacts, previous attempts of conservation, and the future use of these artefacts. The technical methods of how the restoration and conservation were made were dealt with only very briefly. Today, sophisticated methods of scientific analysis such as DNA are common place, and this encourages conservators and scientists to work together to work out the development of new methods for analysis and conservation of artefacts. This book focuses on the chemicals used for conservation and restoration of various artefacts in artwork and archaeology, as well as special applications of these materials. Also the methods used, both methods for cleaning, conservation and restoration, as well as methods for the analysis of the state of the respective artefacts. Topics include oil paintings, paper conservation, textiles and dyes for them, archaeological wood, fossils, stones, metals and metallic coins, and glasses, including church windows.

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Автор: Jens Hagen

Kenntnisse der Auslegung und Simulation von Chemiereaktoren sind die Voraussetzung fur den optimalen technischen und wirtschaftlichen Betrieb von chemischen Prozessen. In der neuen Auflage von «Chemiereaktoren» gibt Jens Hagen einen bewahrten und verstandlichen Einstieg in das komplexe Thema und vermittelt die Grundlagen der Reaktionstechnik. Alle erforderlichen Auslegungsgleichungen auf Basis der Stoff-, Warme- und Impulsbilanz unter Berucksichtigung von Stochiometrie und Kinetik der Reaktionen werden abgeleitet und erlautert. Jedes Kapitel enthalt vollstandig durchgerechnete Beispiele und Ubungsaufgaben mit kommentierten Losungen. Um einen Einstieg in die Modellierung und Simulation von Chemiereaktoren zu geben, nutzt Jens Hagen das Softwarepaket POLYMATH, das das Finden von numerischen Problemlosungen leicht nachvollziehbar und mit geringem Aufwand erlaubt. Zielgerichtet wird die Modellierung von Problemstellungen geubt und es werden verstandliche Losungswege aufgezeigt, um Probleme aus der Praxis zu losen. In der zweiten Auflage wurde das Buch um die Losung von Differenzialgleichungen zweiter Ordnung und von partiellen Differenzialgleichungen erweitert, um komplexere Fragestellungen des Stoff- und Warmeaustauschs losen zu konnen. Zusatzlich wurden viele neue Beispiele und Simulationen aufgenommen, die reale Probleme in der Reaktionstechnik widerspiegeln und eine Ubertragung der Beispiele in die Praxis erleichtern.

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Автор: Группа авторов

Dieses praktisch orientierte Buch prasentiert systematisch neue und aktuelle Konzepte fur Chemiestandorte. Geschrieben von einem renommierten Autorenteam aus Wissenschaft, Beratung & Praxis ist das Buch ein Muss fur jedermann aus dieser Branche.

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Автор: Группа авторов

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

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Автор: Группа авторов

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

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Автор: Emmanuel Ohene Afoakwa

This second edition provides information on recent advances in the science and technology of chocolate manufacture and the entire international cocoa industry. It provides detailed review on a wide range of topics including cocoa production, cocoa and chocolate manufacturing operations, sensory perception of chocolate quality, flavour release and perception, sugar replacement and alternative sweetening solutions in chocolate production, industrial manufacture of sugar-free chocolates as well as the nutrition and health benefits of cocoa and chocolate consumption. The topics cover modern cocoa cultivation and production practices with special attention on cocoa bean composition, genotypic variations in the bean, post-harvest pre-treatments, fermentation and drying processes, and the biochemical basis of these operations. The scientific principles behind industrial chocolate manufacture are outlined with detailed explanations of the various stages of chocolate manufacturing including mixing, refining, conching and tempering. Other topics covered include the chemistry of flavour formation and development during cocoa processing and chocolate manufacture; volatile flavour compounds and their characteristics and identification; sensory descriptions and character; and flavour release and perception in chocolate. The nutritional and health benefits of cocoa and chocolate consumption as well as the application of HACCP and other food safety management systems such as ISO 22,000 in the chocolate processing industry are also addressed. Additionally, detailed research on the influence of different raw materials and processing operations on the flavour and other quality characteristics of chocolates have been provided with scope for process optimization and improvement. The book is intended to be a desk reference for all those engaged in the business of making and using chocolate worldwide; confectionery and chocolate scientists in industry and academia; students and practising food scientists and technologists; nutritionists and other health professionals; and libraries of institutions where agriculture, food science and nutrition is studied and researched.

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Автор: Bangjun Lei

A practical introduction to intelligent computer vision theory, design, implementation, and technology The past decade has witnessed epic growth in image processing and intelligent computer vision technology. Advancements in machine learning methods—especially among adaboost varieties and particle filtering methods—have made machine learning in intelligent computer vision more accurate and reliable than ever before. The need for expert coverage of the state of the art in this burgeoning field has never been greater, and this book satisfies that need. Fully updated and extensively revised, this 2nd Edition of the popular guide provides designers, data analysts, researchers and advanced post-graduates with a fundamental yet wholly practical introduction to intelligent computer vision. The authors walk you through the basics of computer vision, past and present, and they explore the more subtle intricacies of intelligent computer vision, with an emphasis on intelligent measurement systems. Using many timely, real-world examples, they explain and vividly demonstrate the latest developments in image and video processing techniques and technologies for machine learning in computer vision systems, including: PRTools5 software for MATLAB—especially the latest representation and generalization software toolbox for PRTools5 Machine learning applications for computer vision, with detailed discussions of contemporary state estimation techniques vs older content of particle filter methods The latest techniques for classification and supervised learning, with an emphasis on Neural Network, Genetic State Estimation and other particle filter and AI state estimation methods All new coverage of the Adaboost and its implementation in PRTools5. A valuable working resource for professionals and an excellent introduction for advanced-level students, this 2nd Edition features a wealth of illustrative examples, ranging from basic techniques to advanced intelligent computer vision system implementations. Additional examples and tutorials, as well as a question and solution forum, can be found on a companion website.

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Автор: Aled Rees

Recognising a need to promote and enhance teaching of clinical endocrinology and diabetes in UK medical schools, the Society for Endocrinology, in collaboration with Diabetes UK and the Association of British Clinical Diabetologists, created a national curriculum that sets out the minimum recommended standards for undergraduate medical education. Clinical Endocrinology and Diabetes at a Glance corresponds to the curriculum and covers all important areas of diabetes and endocrinology in a clinically relevant and concise manner, with complementary figures to ensure principles are explained clearly. It highlights key practical skills for undergraduates in line with the GMC recommendations that medical graduates should be well prepared for their Foundation posts. There is also emphasis on the importance of multidisciplinary teams in the management of endocrine diseases and diabetes. These include sections on structured education programmes, psychosocial aspects, and patient self-management and monitoring. Clinical Endocrinology and Diabetes at a Glance will serve as a valuable resource for medical students and junior doctors treating patients with these conditions.

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Автор: Melissa L. Freeman

Latino/as are the fastest growing demographic in the United States. Despite recent gains in postsecondary enrollment, the Latino/a population is severely underrepresented when it comes to baccalaureate attainment. Hispanic-serving institutions (HSIs) will play a critical role in turning the tide, but there is little existing research about these institutions. This volume synthesizes: Existing research on HSIs, emerging HSIs, as well as research about Latino/a students themselves, A wide range of best practices across institutional types, and Examples of service to undocumented students in states where they do and do not quality for in-state tuition benefits. Topics include Latino/a undergraduate student success, graduate student success, community colleges, four-year institutions, financial aid, and undocumented students. This is the 172nd volume of the Jossey-Bass quarterly report series New Directions for Higher Education. Addressed to presidents, vice presidents, deans, and other higher education decision makers on all kinds of campuses, it provides timely information and authoritative advice about major issues and administrative problems confronting every institution.

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Автор: Edwin B. Faulkner

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Автор: Franz Winter

Combustion, the process of burning, is defined as a chemical reaction between a combustible reactant (the fuel) and an oxidizing agent (such as air) in order to produce heat and in most cases light while new chemical species (e.g., flue gas components) are formed. This book covers a gap on the market by providing a concise introduction to combustion. Most of the other books currently available are targeted towards the experienced users and contain too many details and/or contain knowledge at a fairly high level. This book provides a brief and clear overview of the combustion basics, suitable for beginners and then focuses on practical aspects, rather than theory, illustrated by a number of industrial applications as examples. The content is aimed to provide a general understanding of the various concepts, techniques and equipment for students at all level as well as practitioners with little or no prior experience in the field. The authors are all international experts in the field of combustion technology and adopt here a clear didactic style with many practical examples to cover the most common solid, liquid and gaseous fuels. The associated environmental impacts are also discussed so that readers can develop an understanding of the major issues and the options available for more sustainable combustion processes. With a foreword by Katharina Kohse-Hoinghaus

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Автор: Группа авторов

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Автор: Группа авторов

Covers a widespread view of Quality by Design (QbD) encompassing the many stages involved in the development of a new drug product. The book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing processes and provides the underpinnings for a science-based regulation of the pharmaceutical industry. Edited by the three renowned researchers in the field, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture guides pharmaceutical engineers and scientists involved in product and process development, as well as teachers, on how to utilize QbD practices and applications effectively while complying with government regulations. The material is divided into three main sections: the first six chapters address the role of key technologies, including process modeling, process analytical technology, automated process control and statistical methodology in supporting QbD and establishing the associated design space. The second section consisting of seven chapters present a range of thoroughly developed case studies in which the tools and methodologies discussed in the first section are used to support specific drug substance and drug-product QbD related developments. The last section discussed the needs for integrated tools and reviews the status of information technology tools available for systematic data and knowledge management to support QbD and related activities. Highlights Demonstrates Quality by Design (QbD) concepts through concrete detailed industrial case studies involving of the use of best practices and assessment of regulatory implications Chapters are devoted to applications of QbD methodology in three main processing sectors—drug substance process development, oral drug product manufacture, parenteral product processing, and solid-liquid processing Reviews the spectrum of process model types and their relevance, the range of state-of-the-art real-time monitoring tools and chemometrics, and alternative automatic process control strategies and methods for both batch and continuous processes The role of the design space is demonstrated through specific examples and the importance of understanding the risk management aspects of design space definition is highlighted Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture is an ideal book for practitioners, researchers, and graduate students involved in the development, research, or studying of a new drug and its associated manufacturing process.

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Автор: Carlos Arcila Calder?n

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Автор: Группа авторов

This book covers a wide range of applications and uses of simulation and modeling techniques in polymer injection molding, filling a noticeable gap in the literature of design, manufacturing, and the use of plastics injection molding. The authors help readers solve problems in the advanced control, simulation, monitoring, and optimization of injection molding processes. The book provides a tool for researchers and engineers to calculate the mold filling, optimization of processing control, and quality estimation before prototype molding.

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Автор: Sina Ebnesajjad

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Автор: Sina Ebnesajjad

This book describes fluorocarbons gases’ preparation process, properties, applications and their evolution over time. The impact of fluorocarbons on the ozone layer and global and the development to mitigate those effects have been specially emphasized.  The first major industrial fluorinated compound was developed in the 1920’s, to replace ammonia and sulfur dioxide refrigerants, at the General Motors Frigidaire Division by Thomas Midgley, Jr. and Albert Leon Henne. They developed a family of fluorocarbons trademarked Freon® for auto air conditioning units revolutionizing the auto industry. Other applications were developed over time including fire extinguishers, propellants, blowing agents, cleaners, anesthesia, artificial blood and others impacting every facet of life. In spite of being in broad global use for nearly a century, fluorocarbon gases have gone through great evolution during the last few decades. In the 1980s it was discovered chlorofluorocarbon (CFC) gases are harmful to the ozone layer, mainly because of their chlorine content. Chlorine was released in the upper atmosphere when chlorofluorocarbon molecules were broken down by the high energy cosmic radiation. CFCs were progressively banned following the Montreal Protocol of 1987. CFCs were replaced by fluorinated gases containing either less chlorine (hydrofluoro-chlorocarbons, or HCFCs), which are much less damaging (about 90% less) to the ozone layer or with fluorinated gases containing no chlorine, i.e. hydrofluorocarbons or HFCs. HFC have no impact on the ozone layer but impact global warming detrimentally. HFCs are usable without need for changes to the existing refrigeration or air conditioning installations. More recently hydrofluoroolefins (HFOs), which have little or no negative impact on global warming, have been developed to replace or reduce the use of HFCs. HFOs are used as single compounds or in blends. Research and development continues to develop and replace the HCFCs and HFCs completely with environmentally friendly products. Concise Handbook of Fluorocarbon Gases  presents a reference and text for the commercial fluorocarbon gases which have great many application in a wide range of industries such as refrigeration and air conditioning, as well as consumer products.

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Автор: Michael Hensel

The current trend for constructing experimental structures is now an international phenomenon. It has been taken up worldwide by design professionals, researchers, educators and students alike. There exist, however, distinct and significant tendencies within this development that require further investigation. This issue of AD takes on this task by examining one of the most promising trajectories in this area, the rise of intensely local architectures. In his seminal essay of 1983, Kenneth Frampton redefined Critical Regionalism by calling for an intensely local approach to architectural design. Today, Frampton’s legacy is regaining relevance for a specific body of work in practice and education focused on the construction of experimental structures. Could this ultimately provide the seeds for a compelling and alternative approach to sustainable design? Contributors include: Barbara Ascher, Peter Buchanan, Karl Otto Ellefsen, David Jolly Monge, Lisbet Harboe, David Leatherbarrow, Areti Markopoulou, Philip Nobel, Rodrigo Rubio, S?ren S S?rensen, Defne Sunguro?lu Hensel. Featured practices: Renzo Piano Building Workshop, Rintala Eggertsson, SHoP, Studio Mumbai, TYIN tegnestue.

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Автор: Johannes Karl Fink

CONTACT LENSES The book focuses on the chemistry and properties of contact lenses and their fabrication methods. With research & development continuing in the field, this comprehensive book takes a look at the last 10 years in terms of new materials, chemistry methods, applications, and fabrication techniques. New applications include drug delivery, lenses for augmented reality, electronic contact lenses, and wearable smart contact lenses. In addition, the book discusses simulation methods for contact lenses, such as ocular topography parameters, gas permeable lenses, and computerized videokeratography. On the fabrication front, several common fabrication methods for contact lenses are detailed, including the computer-aided contact lens design, methods for the fabrication of colored contact lenses, and the fabrication of decentered contact lenses. Special processes are reviewed, including, mold processes, reactive ion etching, electrospinning, and others. Also discussed are the properties of contact lenses and methods for the measurement. Many of the standard methods are discussed, but other issues are taken up too including a discussion on the assessment of cytotoxic effects, the Schirmer tear test, and others. The book concludes with a chapter detailing the possible medical problems related to contact lenses and how to avoid them. These include eye diseases, allergic and toxic reactions, as well as methods for medical treatment such as disinfection agents. Audience The book will be used by chemists, polymer scientists, ophthalmologists, engineers in the contact lens industry as well as polymer industries.

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Автор: Patricia K. Farris

Provide expert advice on cosmeceuticals and integrate them into your cosmetic practice Patients look to you for expert advice on topical skin care product, and cosmeceuticals are an important innovation. They want to know which products will work best for them. But new products seem to appear almost daily. How can you provide your patients with effective advice on how and when to use cosmeceuticals? In Cosmeceuticals and Cosmetic Practice, Dr Farris has invited leading experts, including cosmetic chemists, researchers and cosmetic dermatologists, to provide these answers. Together they have analysed and synthesized the evidence and combined it with their experience to provide you with best-practice advice on the most effective way to apply cosmeceuticals in your everyday practice. This book explains: • How cosmeceutical products are developed, tested and how they work • The most up-to-date key ingredients such as: Vitamin antioxidants Botanicals Peptides Growth factors Stem cells • How to use cosmeceuticals in practice Cosmeceuticals and Cosmetic Practice shows you how to improve the health and appearance of your patients’ skin. Titles of related interest Dermatologic Surgery: Step by Step Nouri (ed.); ISBN 978-1-4443-3067-0 Ethnic Dermatology: Principles and Practice Dadize, Petit, Alexis (eds); ISBN 978-0-470-65857-4 Diagnostic Dermoscopy: The Illustrated Guide Bowling; ISBN 978-1-4051-9855-4

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Автор: Wilfried R?hse

A guide to cosmetic creams that focuses on formulation, production, and safety concerns Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products puts the focus on the structure and formulation of a cosmetic cream, the production process, the effect of each ingredient, as well as safety considerations. Comprehensive in scope, the book contains a basic definition of cosmetics and describes the types of skin creams currently on the market, the major ingredients used, and example compositions. The author, Wilfried R?hse?a noted expert on the topic?offers guidelines for estimating manufacturing costs and includes procedures for an effective safety assessment. The book contains information on various aspects of skin penetration and production and covers issues like materials used and hygienic packaging. In addition, R?hse reviews legal regulations with an emphasis on the European market. He discusses GMP and EHEDG directives. This important book: -Offers a comprehensive resource that explores all aspects of cosmetic cream manufacturing and marketing -Provides valuable guidelines for practitioners in the field -Covers the underlying technologies of cosmetic creams -Includes a review of raw material and manufacturing costs, hygiene and safety, and legal regulations -Written by an author with more than 30 years? experience in the industry Written for cosmetic chemists, chemists in industry, chemical engineers, dermatologists, Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products, offers a unique industrial perspective of the topic that is comprehensive in scope.

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Автор: Группа авторов

International trade in high value perishables has grown enormously in the past few decades. In the developed world consumers now expect to be able to eat perishable produce from all parts of the world, and in most cases throughout the year. Perishable plant products are, however, susceptible to physical damage and often have a potential storage life of only a few days. Given their key importance in the world economy, Crop Post-Harvest Science and Technology: Perishables devotes itself to perishable produce, providing current and comprehensive knowledge on all the key factors affecting post-harvest quality of fruits and vegetables. This volume focuses explicitly on the effects and causes of deterioration, as well as the many techniques and practices implemented to maintain quality though correct handling and storage. As highlighted throughout, regular losses caused by post-harvest spoilage of perishable products can be as much as 50%. A complete understanding, as provided by this excellent volume, is therefore vital in helping to reduce these losses by a significant percentage. Compiled by members of the world-renowned Natural Resources Institute at the United Kingdom's University of Greenwich, with contributions from experts around the world, this volume is an essential reference for all those working in the area. Researchers and upper-level students in food science, food technology, post-harvest science and technology, crop protection, applied biology and plant and agricultural sciences will benefit from this landmark publication. Libraries in all research establishments and universities where these subjects are studied and taught should ensure that they have several copies for their shelves.

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Автор: Hsien-Hsin Tung

Filled with industrial examples emphasizing the practical applications of crystallization methodologies Based on the authors' hands-on experiences as process engineers at Merck, Crystallization of Organic Compounds guides readers through the practical aspects of crystallization. It uses plenty of case studies and examples of crystallization processes, ranging from development through manufacturing scale-up. The book not only emphasizes strategies that have been proven successful, it also helps readers avoid common pitfalls that can render standard procedures unsuccessful. The goal of this text is twofold: Build a deeper understanding of the fundamental properties of crystallization as well as the impact of these properties on crystallization process development. Improve readers' problem-solving abilities by using actual industrial examples with real process constraints. Crystallization of Organic Compounds begins with detailed discussions of fundamental thermodynamic properties, nucleation and crystal growth kinetics, process dynamics, and scale-up considerations. Next, it investigates modes of operation, including cooling, evaporation, anti-solvent, and reactive crystallization. The authors conclude with special applications such as ultrasound in crystallization and computational fluid dynamics in crystallization. Most chapters feature multiple examples that guide readers step by step through the crystallization of active pharmaceutical ingredients (APIs). With its focus on industrial applications, this book is recommended for chemical engineers and chemists who are involved with the development, scale-up, or operation of crystallization processes in the pharmaceutical and fine chemical industries.

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Автор: Guozheng Kang

New contributions to the cyclic plasticity of engineering materials Written by leading experts in the field, this book provides an authoritative and comprehensive introduction to cyclic plasticity of metals, polymers, composites and shape memory alloys. Each chapter is devoted to fundamentals of cyclic plasticity or to one of the major classes of materials, thereby providing a wide coverage of the field. The book deals with experimental observations on metals, composites, polymers and shape memory alloys, and the corresponding cyclic plasticity models for metals, polymers, particle reinforced metal matrix composites and shape memory alloys. Also, the thermo-mechanical coupled cyclic plasticity models are discussed for metals and shape memory alloys. Key features: Provides a comprehensive introduction to cyclic plasticity Presents Macroscopic and microscopic observations on the ratchetting of different materials Establishes cyclic plasticity constitutive models for different materials. Analysis of cyclic plasticity in engineering structures. This book is an important reference for students, practicing engineers and researchers who study cyclic plasticity in the areas of mechanical, civil, nuclear, and aerospace engineering as well as materials science.

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Автор: Igor A. Balagansky

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Автор: Igor A. Balagansky

Comprehensive coverage of weapon damage effects on a variety of objects Damaging Effects of Weapons and Ammunition delivers a thorough exploration of a range of issues related to the effects of ammunition and weapons. The book includes coverage of the basic concepts of the theory of efficiency and the physical foundations of the functional and damaging effects of fragments, shaped charges, high-explosive and penetrating weapons. The author discusses the calculation formulas used to evaluation the parameters of damage fields and their interaction with various objects. Additionally, the book expands on the damage criteria of weapons, the characteristics of the vulnerability of objects with respect to a variety of damaging factors, dependencies for assessing safe distances, and the resistance of various structures to the effects of explosion and impact. Damaging Effects of Weapons and Ammunition also offers: Detailed calculation methods indicating areas of application and the necessary units of used quantities Extensive examples of classic designs of ammunition from around the world Discussions of the characterization of various types of ammunition, including high-explosive, fragment, penetrative, and shaped charges A chapter on the numerical simulation of high-speed processes Perfect for technical specialists working in the fields of explosion safety and explosives, Damaging Effects of Weapons and Ammunition also belongs in the libraries of researchers and students studying explosion phenomena, explosive technologies, explosion safety, and materials science.

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Автор: Katharina Rau

Die Darmgesundheit nimmt eine sehr wichtige Rolle in unserer Lebensweise ein. Wenn ihr nicht genug Beachtung geschenkt wird, r?cht sich das meistens. Die kleinen guten Bakterien im Darm wollen gef?ttert und gepflegt werden. Doch das ist gar nicht so leicht. Falsche Nahrungsmittel k?nnen das Wachstum von ung?nstigen Darmbakterien f?rdern. Wenn diese sich breitmachen, geht es uns meist nicht gut. Sicher fragen Sie sich, was Sie selbst f?r Ihre Darmgesundheit tun k?nnen. In meinem E-Book zeige ich Ihnen, was es zu beachten gibt, wie die t?gliche Ern?hrung gestaltet werden kann und gebe Ihnen neben Tipps und Tricks auch alltagstaugliche Rezepte mit an die Hand. Dieses E-Book soll Ihnen eine Hilfestellung f?r die Darmgesundheit bieten. Zudem zeigt es Ihnen einen Weg durch den Ern?hrungsdschungel in dem es auch um Kartoffelfasern, Inulin, Yac?n, intuitives Essen und mehr geht.

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Автор: Группа авторов

Addresses the impacts of data mining on education and reviews applications in educational research teaching, and learning This book discusses the insights, challenges, issues, expectations, and practical implementation of data mining (DM) within educational mandates. Initial series of chapters offer a general overview of DM, Learning Analytics (LA), and data collection models in the context of educational research, while also defining and discussing data mining’s four guiding principles— prediction, clustering, rule association, and outlier detection. The next series of chapters showcase the pedagogical applications of Educational Data Mining (EDM) and feature case studies drawn from Business, Humanities, Health Sciences, Linguistics, and Physical Sciences education that serve to highlight the successes and some of the limitations of data mining research applications in educational settings. The remaining chapters focus exclusively on EDM’s emerging role in helping to advance educational research—from identifying at-risk students and closing socioeconomic gaps in achievement to aiding in teacher evaluation and facilitating peer conferencing. This book features contributions from international experts in a variety of fields. Includes case studies where data mining techniques have been effectively applied to advance teaching and learning Addresses applications of data mining in educational research, including: social networking and education; policy and legislation in the classroom; and identification of at-risk students Explores Massive Open Online Courses (MOOCs) to study the effectiveness of online networks in promoting learning and understanding the communication patterns among users and students Features supplementary resources including a primer on foundational aspects of educational mining and learning analytics Data Mining and Learning Analytics: Applications in Educational Research is written for both scientists in EDM and educators interested in using and integrating DM and LA to improve education and advance educational research.

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Автор: Mai Lyra

Ab 18 Jahren. Deutsch-Englisch. Hat der Mensch einen Hang zur Lyrik, entdeckt sie einen irgendwann immer, indem sie ihm wie durch den Wind oder bei anderer Gelegenheit zu- und eingefl?stert wird. Ist man vielf?ltig ausgebildet wie die Autorin, ist die Lyrik entsprechend gerichtet – wie von selbst! Viel Freude und Inspiration f?r das eigene Leben!

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Автор: Ronald Attanasio

DENTAL MANAGEMENT OF SLEEP DISORDERS [b]A clinically focused, updated, and expanded edition of the leading resource on the dental management of sleep disorders The newly revised Second Edition of Dental Management of Sleep Disorders delivers a focused and authoritative exploration of the dentist’s role in managing patients with sleep problems, especially sleep-related breathing disorders and bruxism. Full discussions of the use of appliances, overviews of current treatment modalities, and investigations of the relationship between sleep disorders and dental and orofacial features accompany detailed chapters on oral appliance therapy, pharmacological, and behavioral management of symptoms. The book includes a variety of revealing case studies that examine the treatment of different sleep disorders, as well as: Thorough introductions to the societal impact of sleep disorders and human sleep architecture and functional anatomy of the airway Comprehensive explorations of the pathophysiology and classification of sleep disorders and sleep disorders in the pediatric population Practical discussions of medical disorders related to obstructive sleep apnea and the dental and orofacial consequences of sleep-related breathing disorders In-depth examinations of the role and interaction of the dentist with the sleep physician and sleep study center Offering practical advice for diagnosis and treatment, Dental Management of Sleep Disorders, Second Edition is a valuable resource for dental practitioners as well as students.

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Автор: Mario Maj M

Depressive disorders have profound social and economic consequences, owing to the suffering and disability they cause. They often occur together with somatic illness which worsens the prognosis of both. Prevention, detection and optimal treatment of these disorders are therefore of great clinical and economic importance. This edition of the first title in the acclaimed Evidence & Experience series from the World Psychiatric Association has been fully revised and features a new section on depression in primary care – the main channel for the management of these disorders in countries around the world. The format remains a systematic review of each topic, evaluating published evidence, complemented by up to six commentaries in which experts provide valuable insight gained from clinical experience. All the evidence, systematically reviewed and analysed, in one place. Practical context imparted in expert commentaries from around the world, which were highly popular in the previous edition. Provides an unbiased and reliable reference source for practising psychiatrists and physicians everywhere. Features a new section on the treatment of depression in primary care. Edited by a highly experienced, internationally renowned team. This book will be informative and stimulating reading for everyone working with people with depressive disorders in all countries and settings: psychiatrists, psychologists, primary care physicians and other mental healthcare professionals. Review of the first edition “The discussion papers are excellent. I strongly recommend this masterfully edited book, which remarkably succeeds in combining research evidence and clinical experience. It is probably the most helpful update on depression available today, both for the researcher in mood disorders and the practising clinician.” S. Grandi in Psychotherapy and Psychosomatics, 2000

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Автор: Vishwas G. Pangarkar

Details simple design methods for multiphase reactors in the chemical process industries Includes basic aspects of transport in multiphase reactors and the importance of relatively reliable and simple procedures for predicting mass transfer parameters Details of design and scale up aspects of several important types of multiphase reactors Examples illustrated through design methodologies presenting different reactors for reactions that are industrially important Includes simple spreadsheet packages rather than complex algorithms / programs or computational aid

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