зарубежная образовательная литература (страница 97)

Автор: Группа авторов

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

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Автор: Группа авторов

The cutting edge of scientific reporting . . . PROGRESS in Inorganic Chemistry Nowhere is creative scientific talent busier than in the world of inorganic chemistry experimentation. Progress in Inorganic Chemistry continues in its tradition of being the most respected avenue for exchanging innovative research. This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. With contributions from internationally renowned chemists, this latest volume offers an in-depth, far-ranging examination of the changing face of the field, providing a tantalizing glimpse of the emerging state of the science. «This series is distinguished not only by its scope and breadth, but also by the depth and quality of the reviews.» —Journal of the American Chemical Society «[This series] has won a deservedly honored place on the bookshelf of the chemist attempting to keep afloat in the torrent of original papers on inorganic chemistry.» —Chemistry in Britain CONTENTS OF VOLUME 54: Atomlike Building Units of Adjustable Character: Solid-State and Solution Routes to Manipulating Hexanuclear Transition Metal Chalcohalide Clusters (Eric J. Welch and Jeffrey R. Long) Doped Semiconductor Nanocrystals: Synthesis, Characterization, Physical Properties, and Applications (J. Daniel Bryan and Daniel R. Gamelin) Stereochemical Aspects of Metal Xanthane Complexes: Molecular Structures and Supramolecular Self-Assembly (Edward R. T. Tiekink and Ionel Haiduc) Trivalent Uranium: A Versatile Species for Molecular Activation (Ilia Korobkov and Sandro Gambarotta) Comparison of the Chemical Biology of NO and HNO: An Inorganic Perspective (Katrina M. Miranda and David A. Wink) Alterations of Nucleobase pKa Values upon Metal Coordination: Origins and Consequences (Bernhard Lippert) Functionalization of Myoglobin (Yoshihito Watanabe and Takashi Hayashi)

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Автор: Группа авторов

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

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Автор: Группа авторов

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

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Автор: Группа авторов

This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 50 continues to report recent advances with a significant, up-to-date selection of contributions on topics such as the following: Structural and mechanistic investigations in asymmetric copper; Catalyzed reactions; Phenoxyl radical complexes; Synthesis of large pore zeolites and molecular sieves; Inorganic nanoclusters with fullerene-like structure and nanotubes

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Автор: Группа авторов

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

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Автор: Группа авторов

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

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Автор: Robert Taft W

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Robert Taft W

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Группа авторов

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Andrew Streitwieser

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Robert Taft W

Progress in Physical Organic Chemistry is dedicated to reviewing the latest investigations into organic chemistry that use quantitative and mathematical methods. These reviews help readers understand the importance of individual discoveries and what they mean to the field as a whole. Moreover, the authors, leading experts in their fields, offer unique and thought-provoking perspectives on the current state of the science and its future directions. With so many new findings published in a broad range of journals, Progress in Physical Organic Chemistry fills the need for a central resource that presents, analyzes, and contextualizes the major advances in the field. The articles published in Progress in Physical Organic Chemistry are not only of interest to scientists working in physical organic chemistry, but also scientists working in the many subdisciplines of chemistry in which physical organic chemistry approaches are now applied, such as biochemistry, pharmaceutical chemistry, and materials and polymer science. Among the topics explored in this series are reaction mechanisms; reactive intermediates; combinatorial strategies; novel structures; spectroscopy; chemistry at interfaces; stereochemistry; conformational analysis; quantum chemical studies; structure-reactivity relationships; solvent, isotope and solid-state effects; long-lived charged, sextet or open-shell species; magnetic, non-linear optical and conducting molecules; and molecular recognition.

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Автор: Elaine Marmel

A comprehensive reference on the latest version of the leading enterprise project management software: Microsoft Project 2010 Microsoft Project allows users to manage business activities effectively by sharing project information, performing modeling and scenario analyses, standardizizing reporting processes, and more. This soup-to-nuts reference covers both the professional and standard versions of the latest iteration of Microsoft Project, as well as Project Server, so that you can efficiently manage your business projects. Veteran author Elaine Marmel begins with an overview of project management basics and then gradually moves on to more advanced topics so that you can learn the scope of what successful project management entails. Popular author Elaine Marmel provides comprehensive coverage of Microsoft Project 2010 and shows you how to successfully manage your business activities Begins with project management basics, such as creating a new project, tracking a project's progress, and working in groups Covers more advanced topics, including customizing Project, using macros, and importing and exporting information Demonstrates how to build tasks, use views, modify the appearance of a project, and resolve scheduling and resource problems With Project 2010 Bible by your side, you’ll learn to confidently and skillfully put Microsoft Project 2010 to work for you.

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Автор: Nancy Muir C

A friendly reference guide to Microsoft Project, the leading enterprise project management software As project management software, Microsoft Project allows you to oversee your business activities effectively. You can manage resources, share project info, perform modeling and scenario analysis, and standardize reporting processes. This easy-to-understand guide is completely updated to cover the latest changes and newest enhancements to Project 2010 and shows you how to get Project 2010 to work for you. After an introduction to basic project management concepts, you’ll discover the mechanics of using Project software to create and manage projects. Other topics covered include working with calendars, using and sharing resources, budgeting, formatting taskbars, gathering and tracking data, working with reports, and creating templates. Microsoft Project allows you to manage resources, share project information, perform scenario analysis, and standardize reporting processes Offers completely updated coverage of the new Project 2010, which is expected to implement the Office Ribbon Reviews formatting taskbars, gathering and tracking data, and working with reports Addresses using and sharing resources, creating templates, and managing projects Let the friendly For Dummies writing style guide you through maximizing the new features of Project 2010.

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Автор: Stanley Portny E

The bestselling 'bible' of project management In today's time-crunched, cost-conscious global business environment, tight project deadlines and stringent expectations are the norm. So how can you juggle all the skills and responsibilities it takes to shine as a project management maven? Updated in a brand-new edition, Project Management For Dummies offers everything you need to successfully manage projects from start to finish—without ever dropping the ball. Written by a well-known project management expert, this hands-on guide takes the perplexity out of being a successful PM, laying out all the steps to take your organizational, planning, and execution skills to new heights. Whether it's managing distressed projects, embracing the use of social media to drive efficiency and improve socialization, or resolving conflicts that occur during a project, the soup-to-nuts guidance inside will help you wear your project management hat more prominently—and proudly. Get the latest in industry best practices reflecting PMBOK 6 Motivate any team to gain maximum productivity Execute projects on time and with maximum efficiency Prepare for the Project Management Professional (PMP) certification exam It's never been easier to execute projects on time, on budget, and with maximum efficiency.

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Автор: Nick Graham

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Автор: Kim Heldman

The much-anticipated new edition of the popular project management introductory book The role of the project manager continues to become more diverse and demanding, placing strong project management skills in high demand. This in-depth introductory guide offers aspiring project managers the essential fundamentals of project management. Fully revised since the previous version, this new edition includes updated project management methods and practices as well as new examples and study questions. Project management guru Kim Heldman presents you with a clear, concise, and enjoyable writing style so that you can approach project management from a practical?rather than theoretical?standpoint. Serves as an introduction to the fundamentals of project management Provides completely updated and revised material on project management methods and practices Features new examples and study questions Addresses how to create project schedules and budgets and define project goals Covers project management principles, Project Management Institute?s project management standards, and practical application of project management for the workplace Whether you're considering a career in project management or simply wish to expand your understanding of general project management principles, Project Management JumpStart, Third Edition is ideal reading.

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Автор: Rory Burke

Project Management Leadership is a comprehensive guide to the human factors involved in Project Management, in particular the leadership skills required to ensure successful implementation of current best practice. It provides the latest insights on team building, motivation, collaboration, and networking skills, and the way these can be harnessed to manage a successful project. Exercises and worked examples are provided throughout.

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Автор: Yuri Raydugin

An easy to implement, practical, and proven risk management methodology for project managers and decision makers Drawing from the author's work with several major and mega capital projects for Royal Dutch Shell, TransCanada Pipelines, TransAlta, Access Pipeline, MEG Energy, and SNC-Lavalin, Project Risk Management: Essential Methods for Project Teams and Decision Makers reveals how to implement a consistent application of risk methods, including probabilistic methods. It is based on proven training materials, models, and tools developed by the author to make risk management plans accessible and easily implemented. Written by an experienced risk management professional Reveals essential risk management methods for project teams and decision makers Packed with training materials, models, and tools for project management professionals Risk Management has been identified as one of the nine content areas for Project Management Professional (PMP®) certification. Yet, it remains an area that can get bogged down in the real world of project management. Practical and clearly written, Project Risk Management: Essential Methods for Project Teams and Decision Makers equips project managers and decision makers with a practical understanding of the basics of risk management as they apply to project management. (PMP and Project Management Professional are registered marks of the Project Management Institute, Inc.)

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Автор: David R. Pierce, Jr

First published in 1988 by RS Means, the new edition of Project Scheduling and Management for Construction has been substantially revised for students enrolled in construction management and civil engineering programs. While retaining its emphasis on developing practical, professional-level scheduling skills, the new edition is a relatable, real-world case study that can be used over the course of a semester. The book also includes classroom elements like exercises, quizzes, skill-building exercises, as well as an instructor's manual including two additional new cases.

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Автор: Aeron Davis

In the twenty-first century, promotion is everywhere and everything has become promotable: everyday goods and organizations, people and ideas, cultures and futures. This engaging book looks at the rise of advertising, public relations, branding, marketing and lobbying, and explores where our promotional times have taken us. Promotional Cultures documents how the professions and practices of promotion have interacted with and reshaped so much in our world, from commodities, celebrities and popular culture to politics, markets and civil society. It offers a mix of historical accounts, social theory and documented case studies, including haute couture fashion, Apple Inc., Hollywood film, Jennifer Lopez, the Occupy movement, Barack Obama’s election campaigns, news production and the 2008 financial crisis. Together, these show how promotional culture may be recorded, understood and interpreted. Promotional Cultures will appeal to students and scholars of media and culture, sociology, politics, anthropology, social and industrial history.

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Автор: Jean Allard

The first edition of this book is considered the bible of this topic… Suffice it to say that there is no other published treatise that approaches the depth of treatment offered by this book. The coverage is the state of the published art, while the added contents cover the new known developments in the field. Haisam Osman; Technology Development Manager, United Launch Alliance This long-awaited second edition of a respected text from world leaders in the field of acoustic materials covers the state of the art with a depth of treatment unrivalled elsewhere. Allard and Atalla employ a logical and progressive approach that leads to a thorough understanding of porous material modelling. The first edition of Propagation of Sound in Porous Media introduced the basic theory of acoustics and the related techniques. Research and development in sound absorption has however progressed significantly since the first edition, and the models and methods described, at the time highly technical and specialized, have since become main stream. In this second edition, several original topics have been revisited and practical prediction methods and industrial applications have been added that increase the breadth of its appeal to both academics and practising engineers. New chapters have also been added on numerical modeling in both low (finite element) and high frequency (Transfer Matrix Method). Collating ‘must-have’ information for engineers working in sound and vibration, Propagation of Sound in Porous Media, 2nd edition offers an indisputable reference to a diverse audience; including graduate students and academics in mechanical & civil engineering, acoustics and noise control, as well as practising mechanical, chemical and materials engineers in the automotive, rail, aerospace, building and civil industries.

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Автор: Alan Romero R

The easy way to make sense of property law Understanding property law is vital for all aspiring lawyers and legal professionals, and property courses are foundational classes within all law schools. Property Law For Dummies tracks to a typical property law course and introduces you to property law and theory, exploring different types of property interests—particularly «real property.» In approachable For Dummies fashion, this book gives you a better understanding of the important property law concepts and aids in the reading and analysis of cases, statutes, and regulations. Tracks to a typical property law course Plain-English explanations make it easier to grasp property law concepts Serves as excellent supplemental reading for anyone preparing for their state's Bar Exam The information in Property Law For Dummies benefits students enrolled in a property law course as well as non-students, landlords, small business owners, and government officials, who want to know more about the ins and outs property law.

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Автор: Friedrich Marks

Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by leading experts, covers the ground-breaking developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists. Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will value this informative introduction to one of the most rapidly developing fields in cell biology.

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Автор: Irfan Ahmad

Prosthodontics at a Glance is a title in the popular At A Glance series and focuses on prosthodontics from diagnostics through treatment to post-operative maintenance. It is an ideal companion for all students of dentistry, clinicians and members of the dental team with an interest in prosthodontics.

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Автор: Rodney Fernandes A

Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

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Автор: Uversky Vladimir

Sheds new light on intrinsically disordered proteins and peptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins and peptides (IDPs), researchers realized that proteins do not necessarily adopt a well defined secondary and tertiary structure in order to perform biological functions. In fact, IDPs play biologically relevant roles, acting as inhibitors, scavengers, and even facilitating DNA/RNA-protein interactions. Due to their propensity for self-aggregation and fibril formation, some IDPs are involved in neurodegenerative diseases such as Parkinson's and Alzheimer's. With contributions from leading researchers, this text reviews the most recent studies, encapsulating our understanding of IDPs. The authors explain how the growing body of IDP research is building our knowledge of the folding process, the binding of ligands to receptor molecules, and peptide self-aggregation. Readers will discover a variety of experimental, theoretical, and computational approaches used to better understand the properties and function of IDPs. Moreover, they'll discover the role of IDPs in human disease and as drug targets. Protein and Peptide Folding, Misfolding, and Non-Folding begins with an introduction that explains why research on IDPs has significantly expanded in the past few years. Next, the book is divided into three sections: Conformational Analysis of Unfolded States Disordered Peptides and Molecular Recognition Aggregation of Disordered Peptides Throughout the book, detailed figures help readers understand the structure, properties, and function of IDPs. References at the end of each chapter serve as a gateway to the growing body of literature in the field. With the publication of Protein and Peptide Folding, Misfolding, and Non-Folding, researchers now have a single place to discover IDPs, their diverse biological functions, and the many disciplines that have contributed to our evolving understanding of them.

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Автор: Martin Rechsteiner

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

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Автор: Martin Rechsteiner

This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research. From the contents: * Ubiquitin and cancer * Ubiquitin and liver cancer * Muscle atrophy * Aggresomes and human disease * Parkin and neurodegeneration * Chronic neurodegenerative diseases * Parkinson's disease * Ubiquitin and viruses * Druggability of the ubiquitin-proteasome system Required reading for molecular and cell biologists, as well as physiologists with an interest in the topic.

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Автор: CIBA Foundation Symposium

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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Автор: Stefan Lutz

Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.

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Автор: Lorenzo Pinna A

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

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Автор: Dev Kambhampati

This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.

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Автор: Lian Lu-Yun

Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.

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Автор: Jan-Christer Janson

The authoritative guide on protein purification—now completely updated and revised Since the Second Edition of Protein Purification was published in 1998, the sequencing of the human genome and other developments in bioscience have dramatically changed the landscape of protein research. This new edition addresses these developments, featuring a wealth of new topics and several chapters rewritten from scratch. Leading experts in the field cover all major biochemical separation methods for proteins in use today, providing professionals in biochemistry, organic chemistry, and analytical chemistry with quick access to the latest techniques. Entirely new or thoroughly revised content includes: High-resolution reversed-phase liquid chromatography Electrophoresis in gels Conventional isoelectric focusing in gel slabs and capillaries and immobilized pH gradients Affinity ligands from chemical and biological combinatorial libraries Membrane separations Refolding of inclusion body proteins from E. coli Purification of PEGylated proteins High throughput screening techniques in protein purification The history of protein chromatography

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Автор: Jan-Christer Janson

The authoritative guide on protein purification—now completely updated and revised Since the Second Edition of Protein Purification was published in 1998, the sequencing of the human genome and other developments in bioscience have dramatically changed the landscape of protein research. This new edition addresses these developments, featuring a wealth of new topics and several chapters rewritten from scratch. Leading experts in the field cover all major biochemical separation methods for proteins in use today, providing professionals in biochemistry, organic chemistry, and analytical chemistry with quick access to the latest techniques. Entirely new or thoroughly revised content includes: High-resolution reversed-phase liquid chromatography Electrophoresis in gels Conventional isoelectric focusing in gel slabs and capillaries and immobilized pH gradients Affinity ligands from chemical and biological combinatorial libraries Membrane separations Refolding of inclusion body proteins from E. coli Purification of PEGylated proteins High throughput screening techniques in protein purification The history of protein chromatography

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Автор: Michael Kinter

How to design, execute, and interpret experiments for protein sequencing using mass spectrometry The rapid expansion of searchable protein and DNA databases in recent years has triggered an explosive growth in the application of mass spectrometry to protein sequencing. This timely and authoritative book provides professionals and scientists in biotechnology research with complete coverage of procedures for analyzing protein sequences by mass spectrometry, including step-by-step guidelines for sample preparation, analysis, and data interpretation. Michael Kinter and Nicholas Sherman present their own high-quality, laboratory-tested protocols for the analysis of a wide variety of samples, demonstrating how to carry out specific experiments and obtain fast, reliable results with a 99% success rate. Readers will get sufficient experimental detail to apply in their own laboratories, learn about the proper selection and operation of instruments, and gain essential insight into the fundamental principles of mass spectrometry and protein sequencing. Coverage includes: Peptide fragmentation and interpretation of product ion spectra Basic polyacrylamide gel electrophoresis Preparation of protein digests for sequencing experiments Mass spectrometric analysis using capillary liquid chromatography Techniques for protein identification by database searches Characterization of modified peptides using tandem mass spectrometry And much more

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Автор: Hiroyuki Osada

Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules

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Автор: CIBA Foundation Symposium

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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Автор: Hugo Kubinyi

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

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Автор: Группа авторов

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach. From the contents: * Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies * Modulators of protein-protein interactions: The importance of Three-Dimensionality * Interactive technologies for leveraging the known chemistry of anchor residues * SH3 Domains as Drug Targets * P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments * Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases * The PIF-binding pocket of AGC kinases * Peptidic inhibitors of protein-protein interactions for cell adhesion receptors * The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases and more

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Автор: Ilya Prigogine

Presenting a wide-ranging view of current developments in protein research, the papers in this collection, each written by highly regarded experts in the field, examine various aspects of protein structure, functions, dynamics, and experimentation. Topics include dynamical simulation methods, the biological role of atom fluctuations, protein folding, influences on protein dynamics, and a variety of analytical techniques, such as X-ray diffraction, vibrational spectroscopy, photodissociation and rebinding kinetics. This is part of a series devoted to providing general information on a wide variety of topics in chemical physics in order to stimulate new research and to serve as a text for beginners in a particular area of chemical physics.

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Автор: Gary Walsh

Proteins Biochemistry and Biotechnology 2e is a definitive source of information for all those interested in protein science, and particularly the commercial production and isolation of specific proteins, and their subsequent utilization for applied purposes in industry and medicine. Fully updated throughout with new or fundamentally revised sections on proteomics as, bioinformatics, protein glycosylation and engineering, well as sections detailing advances in upstream processing and newer protein applications such as enzyme-based biofuel production this new edition has an increased focus on biochemistry to ensure the balance between biochemisty and biotechnology, enhanced with numerous case studies. This second edition is an invaluable text for undergraduates of biochemistry and biotechnology but will also be relevant to students of microbiology, molecular biology, bioinformatics and any branch of the biomedical sciences who require a broad overview of the various medical, diagnostic and industrial uses of proteins. • Provides a comprehensive overview of all aspects of protein biochemisty and protein biotechnology • Includes numerous case studies • Increased focus on protein biochemistry to ensure balance between biochemisty and biotechnology • Includes new section focusing on proteomics as well as sections detailing protein function and enzyme-based biofuel production "With the potential of a standard reference source on the topic, any molecular biotechnologist will profit greatly from having this excellent book. « (Engineering in Life Sciences, 2004; Vol 5; No. 5) “Few texts would be considered competitors, and none compare favorably.» (Biochemistry and Molecular Education, July/August 2002) «…The book is well written, making it informative and easy to read…» (The Biochemist, June 2002)

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Автор: Michael Dunn J

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease – the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

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Автор: Hugo Kubinyi

From skillful handling of the wide range of technologies to successful applications in drug discovery – this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

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Автор: Reiner Westermeier

Still the only concise practical guide to laboratory experiments in proteomics, this new edition now also covers DIGE technology and liquid-chromatography, while the troubleshooting section has been considerably extended. Adopting a practical approach, the authors present the relevant techniques and explain the route to successful experimental design and optimal method selection. They cover such electrophoretic techniques as isoelectric focusing, SDS page, 2-D page, and DIGE, as well as liquid-chromatography techniques, such as ion exchange, affinity chromatography and reversed-phase HPLC. Mass-spectrometric techniques include MALDI, ESI, and FT ICR. Generously illustrated, partly in color, the book also features updates of protocols as well as animations illustrating crucial methodological steps on a companion website.

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